Fluorine in PDB 7axs: Structural Characterisation of WDR5:Cs-VIP8 Interaction in Cis State 1

The structure of Structural Characterisation of WDR5:Cs-VIP8 Interaction in Cis State 1, PDB code: 7axs was solved by L.Werel, L.-O.Essen, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	44.47 / 1.88
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	47.022, 47.163, 133.46, 90, 90, 90
R / Rfree (%)	20 / 23.5

The binding sites of Fluorine atom in the Structural Characterisation of WDR5:Cs-VIP8 Interaction in Cis State 1 (pdb code 7axs). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 4 binding sites of Fluorine where determined in the Structural Characterisation of WDR5:Cs-VIP8 Interaction in Cis State 1, PDB code: 7axs:
Jump to Fluorine binding site number: 1; 2; 3; 4;

Fluorine binding site 1 out of 4 in the Structural Characterisation of WDR5:Cs-VIP8 Interaction in Cis State 1


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Structural Characterisation of WDR5:Cs-VIP8 Interaction in Cis State 1 within 5.0Å range: probe atom residue distance (Å) B Occ B:F7 b:39.7 occ:1.00 FA2 B:S7Z7 0.0 39.7 1.0 CA2 B:S7Z7 1.4 38.7 1.0 CA1 B:S7Z7 2.4 39.7 1.0 CA3 B:S7Z7 2.4 38.0 1.0 NA1 B:S7Z7 2.9 41.1 1.0 CA6 B:S7Z7 3.6 39.0 1.0 CA4 B:S7Z7 3.7 35.9 1.0 FB2 B:S7Z7 3.7 41.4 1.0 NB1 B:S7Z7 3.8 40.2 1.0 CA5 B:S7Z7 4.1 37.5 1.0 CB2 B:S7Z7 4.5 40.8 1.0 CB1 B:S7Z7 4.6 41.2 1.0 FA6 B:S7Z7 4.7 40.9 1.0 O B:HOH104 4.9 28.5 1.0 CA B:S7Z7 4.9 31.9 1.0

Fluorine binding site 2 out of 4 in the Structural Characterisation of WDR5:Cs-VIP8 Interaction in Cis State 1


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Structural Characterisation of WDR5:Cs-VIP8 Interaction in Cis State 1 within 5.0Å range: probe atom residue distance (Å) B Occ B:F7 b:40.9 occ:1.00 FA6 B:S7Z7 0.0 40.9 1.0 CA6 B:S7Z7 1.4 39.0 1.0 CA1 B:S7Z7 2.3 39.7 1.0 CA5 B:S7Z7 2.4 37.5 1.0 NA1 B:S7Z7 2.7 41.1 1.0 FB6 B:S7Z7 3.2 41.4 1.0 NB1 B:S7Z7 3.2 40.2 1.0 CB6 B:S7Z7 3.2 41.5 1.0 CB1 B:S7Z7 3.2 41.2 1.0 CE1 B:DPN5 3.3 26.5 1.0 CD1 B:DPN5 3.5 27.4 1.0 CA2 B:S7Z7 3.6 38.7 1.0 CA4 B:S7Z7 3.6 35.9 1.0 NZ A:LYS259 3.7 40.0 1.0 CB5 B:S7Z7 4.1 40.8 1.0 CA3 B:S7Z7 4.1 38.0 1.0 CB2 B:S7Z7 4.1 40.8 1.0 CZ B:DPN5 4.2 26.2 1.0 CG B:DPN5 4.4 27.7 1.0 CE A:LYS259 4.6 38.5 1.0 FA2 B:S7Z7 4.7 39.7 1.0 FB2 B:S7Z7 4.8 41.4 1.0 CB4 B:S7Z7 4.8 41.0 1.0 CB3 B:S7Z7 4.8 40.9 1.0 CA B:S7Z7 4.9 31.9 1.0 CE2 B:DPN5 4.9 26.4 1.0

Fluorine binding site 3 out of 4 in the Structural Characterisation of WDR5:Cs-VIP8 Interaction in Cis State 1


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Structural Characterisation of WDR5:Cs-VIP8 Interaction in Cis State 1 within 5.0Å range: probe atom residue distance (Å) B Occ B:F7 b:41.4 occ:1.00 FB2 B:S7Z7 0.0 41.4 1.0 CB2 B:S7Z7 1.4 40.8 1.0 CB3 B:S7Z7 2.4 40.9 1.0 CB1 B:S7Z7 2.4 41.2 1.0 NB1 B:S7Z7 2.8 40.2 1.0 NA1 B:S7Z7 3.5 41.1 1.0 CA1 B:S7Z7 3.6 39.7 1.0 CB6 B:S7Z7 3.6 41.5 1.0 CB4 B:S7Z7 3.6 41.0 1.0 CA2 B:S7Z7 3.7 38.7 1.0 FA2 B:S7Z7 3.7 39.7 1.0 O B:HOH110 3.8 41.0 1.0 CB5 B:S7Z7 4.1 40.8 1.0 CA6 B:S7Z7 4.3 39.0 1.0 CA3 B:S7Z7 4.5 38.0 1.0 FA6 B:S7Z7 4.8 40.9 1.0 FB6 B:S7Z7 4.8 41.4 1.0 O B:HOH104 5.0 28.5 1.0

Fluorine binding site 4 out of 4 in the Structural Characterisation of WDR5:Cs-VIP8 Interaction in Cis State 1


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Structural Characterisation of WDR5:Cs-VIP8 Interaction in Cis State 1 within 5.0Å range: probe atom residue distance (Å) B Occ B:F7 b:41.4 occ:1.00 FB6 B:S7Z7 0.0 41.4 1.0 CB6 B:S7Z7 1.4 41.5 1.0 CB5 B:S7Z7 2.4 40.8 1.0 CB1 B:S7Z7 2.4 41.2 1.0 NB1 B:S7Z7 2.8 40.2 1.0 FA6 B:S7Z7 3.2 40.9 1.0 O B:HOH111 3.4 55.9 1.0 CB2 B:S7Z7 3.7 40.8 1.0 NA1 B:S7Z7 3.7 41.1 1.0 CB4 B:S7Z7 3.7 41.0 1.0 CB3 B:S7Z7 4.2 40.9 1.0 CA6 B:S7Z7 4.2 39.0 1.0 CA1 B:S7Z7 4.4 39.7 1.0 NZ A:LYS259 4.8 40.0 1.0 FB2 B:S7Z7 4.8 41.4 1.0 CB B:S7Z7 4.9 41.1 1.0 OB B:S7Z7 4.9 40.6 1.0 CE1 B:DPN5 4.9 26.5 1.0 CD1 B:DPN5 5.0 27.4 1.0

L.Albert, J.Nagpal, W.Steinchen, L.Zhang, L.Werel, N.Djokovic, D.Ruzic, M.Hoffarth, J.Xu, J.Kaspareit, F.Abendroth, A.Royant, G.Bange, K.Nikolic, S.Ryu, Y.Dou, L.-O.Essen, O.Vazquez. Bistable Photoswitch Allows in Vivo Control of Hematopoiesis To Be Published.