Fluorine in PDB 7b05: TRPC4 in Complex with Inhibitor Gfb-8749

The structure of TRPC4 in Complex with Inhibitor Gfb-8749 also contains other interesting chemical elements:

Calcium	(Ca)	4 atoms
Chlorine	(Cl)	4 atoms

The binding sites of Fluorine atom in the TRPC4 in Complex with Inhibitor Gfb-8749 (pdb code 7b05). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 8 binding sites of Fluorine where determined in the TRPC4 in Complex with Inhibitor Gfb-8749, PDB code: 7b05:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8;

Fluorine binding site 1 out of 8 in the TRPC4 in Complex with Inhibitor Gfb-8749


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of TRPC4 in Complex with Inhibitor Gfb-8749 within 5.0Å range: probe atom residue distance (Å) B Occ A:F1001 b:79.3 occ:1.00 FAA A:SJQ1001 0.0 79.3 1.0 CAB A:SJQ1001 1.4 79.3 1.0 FAE A:SJQ1001 2.2 79.3 1.0 CAC A:SJQ1001 2.3 79.3 1.0 CAF A:SJQ1001 2.3 79.3 1.0 CAD A:SJQ1001 3.0 79.3 1.0 CAG A:SJQ1001 3.1 79.3 1.0 CAH A:SJQ1001 3.7 79.3 1.0 OH A:TYR646 3.9 54.6 1.0 CE1 A:PHE366 4.0 63.3 1.0 CAI A:SJQ1001 4.5 79.3 1.0 CD1 A:LEU495 4.5 56.6 1.0 CD1 A:PHE366 4.6 63.3 1.0 OG1 A:THR370 4.6 64.8 1.0 CG A:LEU495 4.8 56.6 1.0 CZ A:PHE366 4.8 63.3 1.0 CB A:LEU495 4.9 56.6 1.0 CA A:LEU495 5.0 56.6 1.0

Fluorine binding site 2 out of 8 in the TRPC4 in Complex with Inhibitor Gfb-8749


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of TRPC4 in Complex with Inhibitor Gfb-8749 within 5.0Å range: probe atom residue distance (Å) B Occ A:F1001 b:79.3 occ:1.00 FAE A:SJQ1001 0.0 79.3 1.0 CAB A:SJQ1001 1.4 79.3 1.0 FAA A:SJQ1001 2.2 79.3 1.0 CAC A:SJQ1001 2.3 79.3 1.0 CAF A:SJQ1001 2.3 79.3 1.0 CD1 A:LEU495 3.2 56.6 1.0 CB A:LEU495 3.6 56.6 1.0 CAD A:SJQ1001 3.7 79.3 1.0 CAG A:SJQ1001 3.7 79.3 1.0 CG A:LEU495 3.8 56.6 1.0 CAH A:SJQ1001 4.1 79.3 1.0 CAI A:SJQ1001 4.1 79.3 1.0 CA A:LEU495 4.2 56.6 1.0 CD2 A:TYR373 4.4 66.7 1.0 N A:LEU495 4.7 56.6 1.0 OG1 A:THR370 4.9 64.8 1.0 CE2 A:TYR373 4.9 66.7 1.0

Fluorine binding site 3 out of 8 in the TRPC4 in Complex with Inhibitor Gfb-8749


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of TRPC4 in Complex with Inhibitor Gfb-8749 within 5.0Å range: probe atom residue distance (Å) B Occ B:F1001 b:79.2 occ:1.00 FAA B:SJQ1001 0.0 79.2 1.0 CAB B:SJQ1001 1.4 79.2 1.0 FAE B:SJQ1001 2.2 79.2 1.0 CAC B:SJQ1001 2.3 79.2 1.0 CAF B:SJQ1001 2.3 79.2 1.0 CAD B:SJQ1001 3.0 79.2 1.0 CAG B:SJQ1001 3.1 79.2 1.0 CAH B:SJQ1001 3.7 79.2 1.0 OH B:TYR646 3.9 54.9 1.0 CE1 B:PHE366 4.0 63.3 1.0 CAI B:SJQ1001 4.5 79.2 1.0 CD1 B:LEU495 4.5 56.9 1.0 CD1 B:PHE366 4.6 63.3 1.0 OG1 B:THR370 4.6 64.5 1.0 CG B:LEU495 4.8 56.9 1.0 CZ B:PHE366 4.8 63.3 1.0 CB B:LEU495 4.9 56.9 1.0 CA B:LEU495 5.0 56.9 1.0

Fluorine binding site 4 out of 8 in the TRPC4 in Complex with Inhibitor Gfb-8749


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of TRPC4 in Complex with Inhibitor Gfb-8749 within 5.0Å range: probe atom residue distance (Å) B Occ B:F1001 b:79.2 occ:1.00 FAE B:SJQ1001 0.0 79.2 1.0 CAB B:SJQ1001 1.4 79.2 1.0 FAA B:SJQ1001 2.2 79.2 1.0 CAC B:SJQ1001 2.3 79.2 1.0 CAF B:SJQ1001 2.3 79.2 1.0 CD1 B:LEU495 3.2 56.9 1.0 CB B:LEU495 3.6 56.9 1.0 CAD B:SJQ1001 3.7 79.2 1.0 CAG B:SJQ1001 3.7 79.2 1.0 CG B:LEU495 3.8 56.9 1.0 CAH B:SJQ1001 4.1 79.2 1.0 CAI B:SJQ1001 4.1 79.2 1.0 CA B:LEU495 4.2 56.9 1.0 CD2 B:TYR373 4.4 66.9 1.0 N B:LEU495 4.7 56.9 1.0 OG1 B:THR370 4.9 64.5 1.0 CE2 B:TYR373 4.9 66.9 1.0

Fluorine binding site 5 out of 8 in the TRPC4 in Complex with Inhibitor Gfb-8749


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 5 of TRPC4 in Complex with Inhibitor Gfb-8749 within 5.0Å range: probe atom residue distance (Å) B Occ C:F1001 b:78.7 occ:1.00 FAA C:SJQ1001 0.0 78.7 1.0 CAB C:SJQ1001 1.4 78.7 1.0 FAE C:SJQ1001 2.2 78.7 1.0 CAC C:SJQ1001 2.3 78.7 1.0 CAF C:SJQ1001 2.3 78.7 1.0 CAD C:SJQ1001 3.0 78.7 1.0 CAG C:SJQ1001 3.1 78.7 1.0 CAH C:SJQ1001 3.7 78.7 1.0 OH C:TYR646 3.9 54.4 1.0 CE1 C:PHE366 4.0 63.0 1.0 CAI C:SJQ1001 4.5 78.7 1.0 CD1 C:LEU495 4.5 56.2 1.0 CD1 C:PHE366 4.6 63.0 1.0 OG1 C:THR370 4.6 64.2 1.0 CG C:LEU495 4.8 56.2 1.0 CZ C:PHE366 4.8 63.0 1.0 CB C:LEU495 4.9 56.2 1.0 CA C:LEU495 5.0 56.2 1.0

Fluorine binding site 6 out of 8 in the TRPC4 in Complex with Inhibitor Gfb-8749


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 6 of TRPC4 in Complex with Inhibitor Gfb-8749 within 5.0Å range: probe atom residue distance (Å) B Occ C:F1001 b:78.7 occ:1.00 FAE C:SJQ1001 0.0 78.7 1.0 CAB C:SJQ1001 1.4 78.7 1.0 FAA C:SJQ1001 2.2 78.7 1.0 CAC C:SJQ1001 2.3 78.7 1.0 CAF C:SJQ1001 2.3 78.7 1.0 CD1 C:LEU495 3.2 56.2 1.0 CB C:LEU495 3.6 56.2 1.0 CAD C:SJQ1001 3.7 78.7 1.0 CAG C:SJQ1001 3.7 78.7 1.0 CG C:LEU495 3.8 56.2 1.0 CAH C:SJQ1001 4.1 78.7 1.0 CAI C:SJQ1001 4.1 78.7 1.0 CA C:LEU495 4.2 56.2 1.0 CD2 C:TYR373 4.4 66.4 1.0 N C:LEU495 4.7 56.2 1.0 OG1 C:THR370 4.9 64.2 1.0 CE2 C:TYR373 4.9 66.4 1.0

Fluorine binding site 7 out of 8 in the TRPC4 in Complex with Inhibitor Gfb-8749


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 7 of TRPC4 in Complex with Inhibitor Gfb-8749 within 5.0Å range: probe atom residue distance (Å) B Occ D:F1001 b:78.8 occ:1.00 FAA D:SJQ1001 0.0 78.8 1.0 CAB D:SJQ1001 1.4 78.8 1.0 FAE D:SJQ1001 2.2 78.8 1.0 CAC D:SJQ1001 2.3 78.8 1.0 CAF D:SJQ1001 2.3 78.8 1.0 CAD D:SJQ1001 3.0 78.8 1.0 CAG D:SJQ1001 3.1 78.8 1.0 CAH D:SJQ1001 3.7 78.8 1.0 OH D:TYR646 3.9 54.0 1.0 CE1 D:PHE366 4.0 62.4 1.0 CAI D:SJQ1001 4.5 78.8 1.0 CD1 D:LEU495 4.5 56.3 1.0 CD1 D:PHE366 4.6 62.4 1.0 OG1 D:THR370 4.6 63.8 1.0 CG D:LEU495 4.8 56.3 1.0 CZ D:PHE366 4.8 62.4 1.0 CB D:LEU495 4.9 56.3 1.0 CA D:LEU495 5.0 56.3 1.0

Fluorine binding site 8 out of 8 in the TRPC4 in Complex with Inhibitor Gfb-8749


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 8 of TRPC4 in Complex with Inhibitor Gfb-8749 within 5.0Å range: probe atom residue distance (Å) B Occ D:F1001 b:78.8 occ:1.00 FAE D:SJQ1001 0.0 78.8 1.0 CAB D:SJQ1001 1.4 78.8 1.0 FAA D:SJQ1001 2.2 78.8 1.0 CAC D:SJQ1001 2.3 78.8 1.0 CAF D:SJQ1001 2.3 78.8 1.0 CD1 D:LEU495 3.2 56.3 1.0 CB D:LEU495 3.6 56.3 1.0 CAD D:SJQ1001 3.7 78.8 1.0 CAG D:SJQ1001 3.7 78.8 1.0 CG D:LEU495 3.8 56.3 1.0 CAH D:SJQ1001 4.1 78.8 1.0 CAI D:SJQ1001 4.1 78.8 1.0 CA D:LEU495 4.2 56.3 1.0 CD2 D:TYR373 4.4 66.0 1.0 N D:LEU495 4.7 56.3 1.0 OG1 D:THR370 4.9 63.8 1.0 CE2 D:TYR373 4.9 66.0 1.0

D.Vinayagam, D.Quentin, J.Yu-Strzelczyk, O.Sitsel, F.Merino, M.Stabrin, O.Hofnagel, M.Yu, M.W.Ledeboer, G.Nagel, G.Malojcic, S.Raunser. Structural Basis of TRPC4 Regulation By Calmodulin and Pharmacological Agents. Elife V. 9 2020.
ISSN: ESSN 2050-084X
PubMed: 33236980
DOI: 10.7554/ELIFE.60603