Fluorine in PDB 7b05: TRPC4 in Complex with Inhibitor Gfb-8749

Other elements in 7b05:

The structure of TRPC4 in Complex with Inhibitor Gfb-8749 also contains other interesting chemical elements:

Calcium (Ca) 4 atoms
Chlorine (Cl) 4 atoms

Fluorine Binding Sites:

The binding sites of Fluorine atom in the TRPC4 in Complex with Inhibitor Gfb-8749 (pdb code 7b05). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 8 binding sites of Fluorine where determined in the TRPC4 in Complex with Inhibitor Gfb-8749, PDB code: 7b05:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8;

Fluorine binding site 1 out of 8 in 7b05

Go back to Fluorine Binding Sites List in 7b05
Fluorine binding site 1 out of 8 in the TRPC4 in Complex with Inhibitor Gfb-8749


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of TRPC4 in Complex with Inhibitor Gfb-8749 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F1001

b:79.3
occ:1.00
FAA A:SJQ1001 0.0 79.3 1.0
CAB A:SJQ1001 1.4 79.3 1.0
FAE A:SJQ1001 2.2 79.3 1.0
CAC A:SJQ1001 2.3 79.3 1.0
CAF A:SJQ1001 2.3 79.3 1.0
CAD A:SJQ1001 3.0 79.3 1.0
CAG A:SJQ1001 3.1 79.3 1.0
CAH A:SJQ1001 3.7 79.3 1.0
OH A:TYR646 3.9 54.6 1.0
CE1 A:PHE366 4.0 63.3 1.0
CAI A:SJQ1001 4.5 79.3 1.0
CD1 A:LEU495 4.5 56.6 1.0
CD1 A:PHE366 4.6 63.3 1.0
OG1 A:THR370 4.6 64.8 1.0
CG A:LEU495 4.8 56.6 1.0
CZ A:PHE366 4.8 63.3 1.0
CB A:LEU495 4.9 56.6 1.0
CA A:LEU495 5.0 56.6 1.0

Fluorine binding site 2 out of 8 in 7b05

Go back to Fluorine Binding Sites List in 7b05
Fluorine binding site 2 out of 8 in the TRPC4 in Complex with Inhibitor Gfb-8749


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of TRPC4 in Complex with Inhibitor Gfb-8749 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F1001

b:79.3
occ:1.00
FAE A:SJQ1001 0.0 79.3 1.0
CAB A:SJQ1001 1.4 79.3 1.0
FAA A:SJQ1001 2.2 79.3 1.0
CAC A:SJQ1001 2.3 79.3 1.0
CAF A:SJQ1001 2.3 79.3 1.0
CD1 A:LEU495 3.2 56.6 1.0
CB A:LEU495 3.6 56.6 1.0
CAD A:SJQ1001 3.7 79.3 1.0
CAG A:SJQ1001 3.7 79.3 1.0
CG A:LEU495 3.8 56.6 1.0
CAH A:SJQ1001 4.1 79.3 1.0
CAI A:SJQ1001 4.1 79.3 1.0
CA A:LEU495 4.2 56.6 1.0
CD2 A:TYR373 4.4 66.7 1.0
N A:LEU495 4.7 56.6 1.0
OG1 A:THR370 4.9 64.8 1.0
CE2 A:TYR373 4.9 66.7 1.0

Fluorine binding site 3 out of 8 in 7b05

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Fluorine binding site 3 out of 8 in the TRPC4 in Complex with Inhibitor Gfb-8749


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of TRPC4 in Complex with Inhibitor Gfb-8749 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:F1001

b:79.2
occ:1.00
FAA B:SJQ1001 0.0 79.2 1.0
CAB B:SJQ1001 1.4 79.2 1.0
FAE B:SJQ1001 2.2 79.2 1.0
CAC B:SJQ1001 2.3 79.2 1.0
CAF B:SJQ1001 2.3 79.2 1.0
CAD B:SJQ1001 3.0 79.2 1.0
CAG B:SJQ1001 3.1 79.2 1.0
CAH B:SJQ1001 3.7 79.2 1.0
OH B:TYR646 3.9 54.9 1.0
CE1 B:PHE366 4.0 63.3 1.0
CAI B:SJQ1001 4.5 79.2 1.0
CD1 B:LEU495 4.5 56.9 1.0
CD1 B:PHE366 4.6 63.3 1.0
OG1 B:THR370 4.6 64.5 1.0
CG B:LEU495 4.8 56.9 1.0
CZ B:PHE366 4.8 63.3 1.0
CB B:LEU495 4.9 56.9 1.0
CA B:LEU495 5.0 56.9 1.0

Fluorine binding site 4 out of 8 in 7b05

Go back to Fluorine Binding Sites List in 7b05
Fluorine binding site 4 out of 8 in the TRPC4 in Complex with Inhibitor Gfb-8749


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of TRPC4 in Complex with Inhibitor Gfb-8749 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:F1001

b:79.2
occ:1.00
FAE B:SJQ1001 0.0 79.2 1.0
CAB B:SJQ1001 1.4 79.2 1.0
FAA B:SJQ1001 2.2 79.2 1.0
CAC B:SJQ1001 2.3 79.2 1.0
CAF B:SJQ1001 2.3 79.2 1.0
CD1 B:LEU495 3.2 56.9 1.0
CB B:LEU495 3.6 56.9 1.0
CAD B:SJQ1001 3.7 79.2 1.0
CAG B:SJQ1001 3.7 79.2 1.0
CG B:LEU495 3.8 56.9 1.0
CAH B:SJQ1001 4.1 79.2 1.0
CAI B:SJQ1001 4.1 79.2 1.0
CA B:LEU495 4.2 56.9 1.0
CD2 B:TYR373 4.4 66.9 1.0
N B:LEU495 4.7 56.9 1.0
OG1 B:THR370 4.9 64.5 1.0
CE2 B:TYR373 4.9 66.9 1.0

Fluorine binding site 5 out of 8 in 7b05

Go back to Fluorine Binding Sites List in 7b05
Fluorine binding site 5 out of 8 in the TRPC4 in Complex with Inhibitor Gfb-8749


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 5 of TRPC4 in Complex with Inhibitor Gfb-8749 within 5.0Å range:
probe atom residue distance (Å) B Occ
C:F1001

b:78.7
occ:1.00
FAA C:SJQ1001 0.0 78.7 1.0
CAB C:SJQ1001 1.4 78.7 1.0
FAE C:SJQ1001 2.2 78.7 1.0
CAC C:SJQ1001 2.3 78.7 1.0
CAF C:SJQ1001 2.3 78.7 1.0
CAD C:SJQ1001 3.0 78.7 1.0
CAG C:SJQ1001 3.1 78.7 1.0
CAH C:SJQ1001 3.7 78.7 1.0
OH C:TYR646 3.9 54.4 1.0
CE1 C:PHE366 4.0 63.0 1.0
CAI C:SJQ1001 4.5 78.7 1.0
CD1 C:LEU495 4.5 56.2 1.0
CD1 C:PHE366 4.6 63.0 1.0
OG1 C:THR370 4.6 64.2 1.0
CG C:LEU495 4.8 56.2 1.0
CZ C:PHE366 4.8 63.0 1.0
CB C:LEU495 4.9 56.2 1.0
CA C:LEU495 5.0 56.2 1.0

Fluorine binding site 6 out of 8 in 7b05

Go back to Fluorine Binding Sites List in 7b05
Fluorine binding site 6 out of 8 in the TRPC4 in Complex with Inhibitor Gfb-8749


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 6 of TRPC4 in Complex with Inhibitor Gfb-8749 within 5.0Å range:
probe atom residue distance (Å) B Occ
C:F1001

b:78.7
occ:1.00
FAE C:SJQ1001 0.0 78.7 1.0
CAB C:SJQ1001 1.4 78.7 1.0
FAA C:SJQ1001 2.2 78.7 1.0
CAC C:SJQ1001 2.3 78.7 1.0
CAF C:SJQ1001 2.3 78.7 1.0
CD1 C:LEU495 3.2 56.2 1.0
CB C:LEU495 3.6 56.2 1.0
CAD C:SJQ1001 3.7 78.7 1.0
CAG C:SJQ1001 3.7 78.7 1.0
CG C:LEU495 3.8 56.2 1.0
CAH C:SJQ1001 4.1 78.7 1.0
CAI C:SJQ1001 4.1 78.7 1.0
CA C:LEU495 4.2 56.2 1.0
CD2 C:TYR373 4.4 66.4 1.0
N C:LEU495 4.7 56.2 1.0
OG1 C:THR370 4.9 64.2 1.0
CE2 C:TYR373 4.9 66.4 1.0

Fluorine binding site 7 out of 8 in 7b05

Go back to Fluorine Binding Sites List in 7b05
Fluorine binding site 7 out of 8 in the TRPC4 in Complex with Inhibitor Gfb-8749


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 7 of TRPC4 in Complex with Inhibitor Gfb-8749 within 5.0Å range:
probe atom residue distance (Å) B Occ
D:F1001

b:78.8
occ:1.00
FAA D:SJQ1001 0.0 78.8 1.0
CAB D:SJQ1001 1.4 78.8 1.0
FAE D:SJQ1001 2.2 78.8 1.0
CAC D:SJQ1001 2.3 78.8 1.0
CAF D:SJQ1001 2.3 78.8 1.0
CAD D:SJQ1001 3.0 78.8 1.0
CAG D:SJQ1001 3.1 78.8 1.0
CAH D:SJQ1001 3.7 78.8 1.0
OH D:TYR646 3.9 54.0 1.0
CE1 D:PHE366 4.0 62.4 1.0
CAI D:SJQ1001 4.5 78.8 1.0
CD1 D:LEU495 4.5 56.3 1.0
CD1 D:PHE366 4.6 62.4 1.0
OG1 D:THR370 4.6 63.8 1.0
CG D:LEU495 4.8 56.3 1.0
CZ D:PHE366 4.8 62.4 1.0
CB D:LEU495 4.9 56.3 1.0
CA D:LEU495 5.0 56.3 1.0

Fluorine binding site 8 out of 8 in 7b05

Go back to Fluorine Binding Sites List in 7b05
Fluorine binding site 8 out of 8 in the TRPC4 in Complex with Inhibitor Gfb-8749


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 8 of TRPC4 in Complex with Inhibitor Gfb-8749 within 5.0Å range:
probe atom residue distance (Å) B Occ
D:F1001

b:78.8
occ:1.00
FAE D:SJQ1001 0.0 78.8 1.0
CAB D:SJQ1001 1.4 78.8 1.0
FAA D:SJQ1001 2.2 78.8 1.0
CAC D:SJQ1001 2.3 78.8 1.0
CAF D:SJQ1001 2.3 78.8 1.0
CD1 D:LEU495 3.2 56.3 1.0
CB D:LEU495 3.6 56.3 1.0
CAD D:SJQ1001 3.7 78.8 1.0
CAG D:SJQ1001 3.7 78.8 1.0
CG D:LEU495 3.8 56.3 1.0
CAH D:SJQ1001 4.1 78.8 1.0
CAI D:SJQ1001 4.1 78.8 1.0
CA D:LEU495 4.2 56.3 1.0
CD2 D:TYR373 4.4 66.0 1.0
N D:LEU495 4.7 56.3 1.0
OG1 D:THR370 4.9 63.8 1.0
CE2 D:TYR373 4.9 66.0 1.0

Reference:

D.Vinayagam, D.Quentin, J.Yu-Strzelczyk, O.Sitsel, F.Merino, M.Stabrin, O.Hofnagel, M.Yu, M.W.Ledeboer, G.Nagel, G.Malojcic, S.Raunser. Structural Basis of TRPC4 Regulation By Calmodulin and Pharmacological Agents. Elife V. 9 2020.
ISSN: ESSN 2050-084X
PubMed: 33236980
DOI: 10.7554/ELIFE.60603
Page generated: Sun Dec 13 13:50:37 2020

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