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Fluorine in PDB 7b1p: Crystal Structure of Human Bace-1 in Complex with Compound 38A (Nb- 854)Enzymatic activity of Crystal Structure of Human Bace-1 in Complex with Compound 38A (Nb- 854)
All present enzymatic activity of Crystal Structure of Human Bace-1 in Complex with Compound 38A (Nb- 854):
3.4.23.46; Protein crystallography data
The structure of Crystal Structure of Human Bace-1 in Complex with Compound 38A (Nb- 854), PDB code: 7b1p
was solved by
J.M.Rondeau,
E.Wirth,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 7b1p:
The structure of Crystal Structure of Human Bace-1 in Complex with Compound 38A (Nb- 854) also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Human Bace-1 in Complex with Compound 38A (Nb- 854)
(pdb code 7b1p). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Crystal Structure of Human Bace-1 in Complex with Compound 38A (Nb- 854), PDB code: 7b1p: Jump to Fluorine binding site number: 1; 2; 3; Fluorine binding site 1 out of 3 in 7b1pGo back to Fluorine Binding Sites List in 7b1p
Fluorine binding site 1 out
of 3 in the Crystal Structure of Human Bace-1 in Complex with Compound 38A (Nb- 854)
Mono view Stereo pair view
Fluorine binding site 2 out of 3 in 7b1pGo back to Fluorine Binding Sites List in 7b1p
Fluorine binding site 2 out
of 3 in the Crystal Structure of Human Bace-1 in Complex with Compound 38A (Nb- 854)
Mono view Stereo pair view
Fluorine binding site 3 out of 3 in 7b1pGo back to Fluorine Binding Sites List in 7b1p
Fluorine binding site 3 out
of 3 in the Crystal Structure of Human Bace-1 in Complex with Compound 38A (Nb- 854)
Mono view Stereo pair view
Reference:
H.Rueeger,
R.Lueoend,
R.Machauer,
S.J.Veenstra,
P.Holzer,
K.Hurth,
M.Voegtle,
M.Frederiksen,
J.M.Rondeau,
M.Tintelnot-Blomley,
L.H.Jacobson,
M.Staufenbiel,
G.Laue,
U.Neumann.
Synthesis of the Potent, Selective, and Efficacious Beta-Secretase (BACE1) Inhibitor Nb-360. J.Med.Chem. 2021.
Page generated: Sat Jul 10 14:02:01 2021
ISSN: ISSN 0022-2623 PubMed: 33844524 DOI: 10.1021/ACS.JMEDCHEM.0C02143 |
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