Fluorine in PDB 7b42: Crystal Structure of C-Met Bound By Compound 8

All present enzymatic activity of Crystal Structure of C-Met Bound By Compound 8:
2.7.10.1;

The structure of Crystal Structure of C-Met Bound By Compound 8, PDB code: 7b42 was solved by G.W.Collie, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	55.62 / 1.80
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	112.220, 42.860, 86.960, 90.00, 122.23, 90.00
R / Rfree (%)	20.2 / 22.5

The binding sites of Fluorine atom in the Crystal Structure of C-Met Bound By Compound 8 (pdb code 7b42). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Crystal Structure of C-Met Bound By Compound 8, PDB code: 7b42:

Fluorine binding site 1 out of 1 in the Crystal Structure of C-Met Bound By Compound 8


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Crystal Structure of C-Met Bound By Compound 8 within 5.0Å range: probe atom residue distance (Å) B Occ A:F1401 b:48.0 occ:1.00 F A:SW81401 0.0 48.0 1.0 C A:SW81401 1.4 45.5 1.0 C21 A:SW81401 2.3 42.7 1.0 C1 A:SW81401 2.4 42.9 1.0 O A:ALA1226 3.0 37.4 1.0 CB A:ALA1226 3.2 34.0 1.0 N A:ASP1222 3.4 27.0 1.0 SD A:MET1229 3.5 56.4 1.0 C2 A:SW81401 3.6 40.5 1.0 CB A:ALA1221 3.6 26.0 1.0 C4 A:SW81401 3.6 40.3 1.0 CD2 A:LEU1140 3.7 26.7 1.0 CB A:MET1229 3.8 48.1 1.0 C A:ALA1226 3.8 38.3 1.0 CA A:ALA1226 3.9 33.3 1.0 CG A:MET1229 4.0 51.8 1.0 CA A:ASP1222 4.1 26.4 1.0 C3 A:SW81401 4.1 40.9 1.0 C A:ALA1221 4.4 29.6 1.0 CA A:ALA1221 4.5 24.5 1.0 CD1 A:LEU1157 4.7 29.6 1.0 C5 A:SW81401 4.9 37.9 1.0 CB A:ASP1222 4.9 27.9 1.0 CA A:MET1229 4.9 46.0 1.0 CE A:MET1229 4.9 53.0 1.0

G.W.Collie, G.W.Collie. N/A N/A.
DOI: 10.1021/ACSMEDCHEMLETT.0C00392