Fluorine in PDB 7b93: Cryo-Em Structure of Mitochondrial Complex I From Mus Musculus Inhibited By Iacs-2858 at 3.0 A

Enzymatic activity of Cryo-Em Structure of Mitochondrial Complex I From Mus Musculus Inhibited By Iacs-2858 at 3.0 A

All present enzymatic activity of Cryo-Em Structure of Mitochondrial Complex I From Mus Musculus Inhibited By Iacs-2858 at 3.0 A:
7.1.1.2;

Other elements in 7b93:

The structure of Cryo-Em Structure of Mitochondrial Complex I From Mus Musculus Inhibited By Iacs-2858 at 3.0 A also contains other interesting chemical elements:

Zinc (Zn) 1 atom
Iron (Fe) 28 atoms

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Cryo-Em Structure of Mitochondrial Complex I From Mus Musculus Inhibited By Iacs-2858 at 3.0 A (pdb code 7b93). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Cryo-Em Structure of Mitochondrial Complex I From Mus Musculus Inhibited By Iacs-2858 at 3.0 A, PDB code: 7b93:
Jump to Fluorine binding site number: 1; 2; 3;

Fluorine binding site 1 out of 3 in 7b93

Go back to Fluorine Binding Sites List in 7b93
Fluorine binding site 1 out of 3 in the Cryo-Em Structure of Mitochondrial Complex I From Mus Musculus Inhibited By Iacs-2858 at 3.0 A


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Cryo-Em Structure of Mitochondrial Complex I From Mus Musculus Inhibited By Iacs-2858 at 3.0 A within 5.0Å range:
probe atom residue distance (Å) B Occ
H:F403

b:47.2
occ:1.00
F1 H:T2Q403 0.0 47.2 1.0
C27 H:T2Q403 1.4 47.2 1.0
F3 H:T2Q403 2.2 47.2 1.0
F2 H:T2Q403 2.2 47.2 1.0
O5' H:T2Q403 2.2 47.2 1.0
CE1 H:PHE49 3.5 47.9 1.0
C5' H:T2Q403 3.5 47.2 1.0
CD1 H:PHE49 3.6 47.9 1.0
C6 H:T2Q403 4.2 47.2 1.0
C4' H:T2Q403 4.4 47.2 1.0
CB H:ALA18 4.5 47.2 1.0
CZ H:PHE49 4.7 47.9 1.0
O H:LEU14 4.8 47.8 1.0
CG H:PHE49 5.0 47.9 1.0

Fluorine binding site 2 out of 3 in 7b93

Go back to Fluorine Binding Sites List in 7b93
Fluorine binding site 2 out of 3 in the Cryo-Em Structure of Mitochondrial Complex I From Mus Musculus Inhibited By Iacs-2858 at 3.0 A


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Cryo-Em Structure of Mitochondrial Complex I From Mus Musculus Inhibited By Iacs-2858 at 3.0 A within 5.0Å range:
probe atom residue distance (Å) B Occ
H:F403

b:47.2
occ:1.00
F2 H:T2Q403 0.0 47.2 1.0
C27 H:T2Q403 1.4 47.2 1.0
F1 H:T2Q403 2.2 47.2 1.0
F3 H:T2Q403 2.2 47.2 1.0
O5' H:T2Q403 2.3 47.2 1.0
C6 H:T2Q403 3.0 47.2 1.0
C5' H:T2Q403 3.0 47.2 1.0
C3I B:PC1203 3.4 50.7 1.0
CE H:MET17 4.3 47.8 1.0
C1 H:T2Q403 4.3 47.2 1.0
C3H B:PC1203 4.3 50.7 1.0
C4' H:T2Q403 4.3 47.2 1.0
CB H:LEU14 4.7 47.8 1.0
C3G B:PC1203 4.8 50.7 1.0
CB H:ALA52 5.0 47.9 1.0

Fluorine binding site 3 out of 3 in 7b93

Go back to Fluorine Binding Sites List in 7b93
Fluorine binding site 3 out of 3 in the Cryo-Em Structure of Mitochondrial Complex I From Mus Musculus Inhibited By Iacs-2858 at 3.0 A


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Cryo-Em Structure of Mitochondrial Complex I From Mus Musculus Inhibited By Iacs-2858 at 3.0 A within 5.0Å range:
probe atom residue distance (Å) B Occ
H:F403

b:47.2
occ:1.00
F3 H:T2Q403 0.0 47.2 1.0
C27 H:T2Q403 1.4 47.2 1.0
F1 H:T2Q403 2.2 47.2 1.0
F2 H:T2Q403 2.2 47.2 1.0
O5' H:T2Q403 2.3 47.2 1.0
C5' H:T2Q403 2.6 47.2 1.0
C6 H:T2Q403 3.0 47.2 1.0
CB H:ALA52 3.3 47.9 1.0
C4' H:T2Q403 3.5 47.2 1.0
C1 H:T2Q403 4.0 47.2 1.0
CD1 H:PHE49 4.0 47.9 1.0
C3I B:PC1203 4.4 50.7 1.0
C3 H:T2Q403 4.4 47.2 1.0
C3G B:PC1203 4.5 50.7 1.0
O H:PRO48 4.5 47.2 1.0
CA H:PHE49 4.6 47.9 1.0
CE1 H:PHE49 4.6 47.9 1.0
C3H B:PC1203 4.6 50.7 1.0
CAB H:T2Q403 4.6 47.2 1.0
CA H:ALA52 4.8 47.9 1.0
C H:PRO48 5.0 47.2 1.0
N H:PHE49 5.0 47.9 1.0

Reference:

I.Chung, R.Serreli, J.B.Cross, M.E.Di Francesco, J.R.Marszalek, J.Hirst. Cork-in-Bottle Mechanism of Inhibitor Binding to Mammalian Complex I. Sci Adv V. 7 2021.
ISSN: ESSN 2375-2548
PubMed: 33990335
DOI: 10.1126/SCIADV.ABG4000
Page generated: Sat Jul 10 14:03:04 2021

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