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Fluorine in PDB 7bjm: Crystal Structure of CHK1-10PT-Mutant Complex with Compound 10Enzymatic activity of Crystal Structure of CHK1-10PT-Mutant Complex with Compound 10
All present enzymatic activity of Crystal Structure of CHK1-10PT-Mutant Complex with Compound 10:
2.7.11.1; Protein crystallography data
The structure of Crystal Structure of CHK1-10PT-Mutant Complex with Compound 10, PDB code: 7bjm
was solved by
P.Dokurno,
A.E.Surgenor,
D.S.Williamson,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of CHK1-10PT-Mutant Complex with Compound 10
(pdb code 7bjm). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Crystal Structure of CHK1-10PT-Mutant Complex with Compound 10, PDB code: 7bjm: Fluorine binding site 1 out of 1 in 7bjmGo back to Fluorine Binding Sites List in 7bjm
Fluorine binding site 1 out
of 1 in the Crystal Structure of CHK1-10PT-Mutant Complex with Compound 10
Mono view Stereo pair view
Reference:
D.S.Williamson,
G.P.Smith,
G.K.Mikkelsen,
T.Jensen,
P.Acheson-Dossang,
L.Badolo,
S.T.Bedford,
V.Chell,
I.J.Chen,
P.Dokurno,
M.Hentzer,
S.Newland,
S.C.Ray,
T.Shaw,
A.E.Surgenor,
L.Terry,
Y.Wang,
K.V.Christensen.
Design and Synthesis of Pyrrolo[2,3- D ]Pyrimidine-Derived Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using A Checkpoint Kinase 1 (CHK1)-Derived Crystallographic Surrogate. J.Med.Chem. 2021.
Page generated: Sat Jul 10 14:02:46 2021
ISSN: ISSN 0022-2623 PubMed: 34184879 DOI: 10.1021/ACS.JMEDCHEM.1C00720 |
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