Fluorine in PDB 7bsv: Cryo-Em Structure of A Human ATP11C-CDC50A Flippase in Ptdser-Occluded E2-Alf State

The structure of Cryo-Em Structure of A Human ATP11C-CDC50A Flippase in Ptdser-Occluded E2-Alf State also contains other interesting chemical elements:

Magnesium	(Mg)	1 atom
Aluminium	(Al)	1 atom

The binding sites of Fluorine atom in the Cryo-Em Structure of A Human ATP11C-CDC50A Flippase in Ptdser-Occluded E2-Alf State (pdb code 7bsv). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 4 binding sites of Fluorine where determined in the Cryo-Em Structure of A Human ATP11C-CDC50A Flippase in Ptdser-Occluded E2-Alf State, PDB code: 7bsv:
Jump to Fluorine binding site number: 1; 2; 3; 4;

Fluorine binding site 1 out of 4 in the Cryo-Em Structure of A Human ATP11C-CDC50A Flippase in Ptdser-Occluded E2-Alf State


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Cryo-Em Structure of A Human ATP11C-CDC50A Flippase in Ptdser-Occluded E2-Alf State within 5.0Å range: probe atom residue distance (Å) B Occ A:F1101 b:39.9 occ:1.00 F1 A:ALF1101 0.0 39.9 1.0 AL A:ALF1101 1.8 39.9 1.0 NZ A:LYS795 2.2 41.6 1.0 OD1 A:ASP409 2.3 34.0 1.0 O A:HOH1204 2.4 30.0 1.0 F3 A:ALF1101 2.5 39.9 1.0 F4 A:ALF1101 2.5 39.9 1.0 OD1 A:ASN819 2.7 41.6 1.0 CG A:ASP409 3.2 34.0 1.0 CE A:LYS795 3.4 41.6 1.0 F2 A:ALF1101 3.6 39.9 1.0 OD2 A:ASP409 3.7 34.0 1.0 OD1 A:ASP820 3.7 41.6 1.0 CG A:ASN819 3.8 41.6 1.0 N A:GLY675 3.9 43.7 1.0 OD2 A:ASP820 4.0 41.6 1.0 O A:ASP179 4.2 47.4 1.0 MG A:MG1102 4.2 39.9 1.0 CG A:ASP820 4.2 41.6 1.0 CA A:THR674 4.2 41.6 1.0 ND2 A:ASN819 4.2 41.6 1.0 C A:THR674 4.3 41.6 1.0 CB A:ASP409 4.3 34.0 1.0 O A:LEU673 4.4 41.6 1.0 CA A:GLY675 4.6 43.7 1.0 CD A:LYS795 4.6 41.6 1.0 CA A:GLY180 4.7 47.1 1.0 C A:ASP179 4.8 47.4 1.0 OG1 A:THR674 4.9 41.6 1.0

Fluorine binding site 2 out of 4 in the Cryo-Em Structure of A Human ATP11C-CDC50A Flippase in Ptdser-Occluded E2-Alf State


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Cryo-Em Structure of A Human ATP11C-CDC50A Flippase in Ptdser-Occluded E2-Alf State within 5.0Å range: probe atom residue distance (Å) B Occ A:F1101 b:39.9 occ:1.00 F2 A:ALF1101 0.0 39.9 1.0 AL A:ALF1101 1.8 39.9 1.0 O A:HOH1204 2.3 30.0 1.0 F3 A:ALF1101 2.5 39.9 1.0 F4 A:ALF1101 2.5 39.9 1.0 CB A:THR411 2.8 41.6 1.0 N A:THR411 2.8 41.6 1.0 OE1 A:GLU181 3.1 50.6 1.0 CA A:THR411 3.2 41.6 1.0 O A:THR411 3.3 41.6 1.0 OD1 A:ASP409 3.3 34.0 1.0 OG1 A:THR411 3.4 41.6 1.0 F1 A:ALF1101 3.6 39.9 1.0 C A:THR411 3.7 41.6 1.0 MG A:MG1102 3.8 39.9 1.0 OD2 A:ASP409 3.9 34.0 1.0 CG A:ASP409 4.0 34.0 1.0 CG2 A:THR411 4.0 41.6 1.0 C A:LYS410 4.0 41.9 1.0 N A:LYS410 4.2 41.9 1.0 OG1 A:THR674 4.3 41.6 1.0 CD A:GLU181 4.3 50.6 1.0 O A:GLY180 4.4 47.1 1.0 CA A:LYS410 4.4 41.9 1.0 CB A:LYS410 4.5 41.9 1.0 C A:GLY180 4.6 47.1 1.0 O A:ASP179 4.8 47.4 1.0 CA A:GLY180 4.8 47.1 1.0 N A:GLY675 4.9 43.7 1.0 CE A:LYS410 4.9 41.9 1.0

Fluorine binding site 3 out of 4 in the Cryo-Em Structure of A Human ATP11C-CDC50A Flippase in Ptdser-Occluded E2-Alf State


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Cryo-Em Structure of A Human ATP11C-CDC50A Flippase in Ptdser-Occluded E2-Alf State within 5.0Å range: probe atom residue distance (Å) B Occ A:F1101 b:39.9 occ:1.00 F3 A:ALF1101 0.0 39.9 1.0 AL A:ALF1101 1.8 39.9 1.0 O A:HOH1204 2.3 30.0 1.0 N A:GLY675 2.5 43.7 1.0 OG1 A:THR674 2.5 41.6 1.0 F2 A:ALF1101 2.5 39.9 1.0 F1 A:ALF1101 2.5 39.9 1.0 CA A:THR674 3.0 41.6 1.0 OD1 A:ASP409 3.0 34.0 1.0 CB A:THR674 3.2 41.6 1.0 C A:THR674 3.2 41.6 1.0 CA A:GLY675 3.5 43.7 1.0 F4 A:ALF1101 3.6 39.9 1.0 N A:ASP676 3.7 51.4 1.0 NZ A:LYS795 4.1 41.6 1.0 C A:GLY675 4.1 43.7 1.0 O A:ASP179 4.1 47.4 1.0 OE1 A:GLU181 4.2 50.6 1.0 CG A:ASP409 4.2 34.0 1.0 N A:LYS410 4.3 41.9 1.0 O A:THR674 4.4 41.6 1.0 N A:THR674 4.4 41.6 1.0 O A:LEU673 4.5 41.6 1.0 N A:THR411 4.5 41.6 1.0 CB A:LYS410 4.5 41.9 1.0 CG2 A:THR674 4.6 41.6 1.0 CB A:ASP676 4.8 51.4 1.0 OD2 A:ASP409 4.8 34.0 1.0 CA A:ASP676 4.8 51.4 1.0 CE A:LYS795 4.8 41.6 1.0 OD1 A:ASN819 4.9 41.6 1.0 C A:LEU673 4.9 41.6 1.0 CE A:LYS410 4.9 41.9 1.0 CA A:LYS410 4.9 41.9 1.0

Fluorine binding site 4 out of 4 in the Cryo-Em Structure of A Human ATP11C-CDC50A Flippase in Ptdser-Occluded E2-Alf State


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Cryo-Em Structure of A Human ATP11C-CDC50A Flippase in Ptdser-Occluded E2-Alf State within 5.0Å range: probe atom residue distance (Å) B Occ A:F1101 b:39.9 occ:1.00 F4 A:ALF1101 0.0 39.9 1.0 AL A:ALF1101 1.8 39.9 1.0 MG A:MG1102 1.8 39.9 1.0 OD2 A:ASP409 2.4 34.0 1.0 O A:HOH1204 2.5 30.0 1.0 F2 A:ALF1101 2.5 39.9 1.0 F1 A:ALF1101 2.5 39.9 1.0 OD1 A:ASP409 2.7 34.0 1.0 CG A:ASP409 2.9 34.0 1.0 O A:THR411 3.3 41.6 1.0 F3 A:ALF1101 3.6 39.9 1.0 OD2 A:ASP820 3.7 41.6 1.0 OD1 A:ASN819 3.9 41.6 1.0 CA A:GLY180 4.0 47.1 1.0 ND2 A:ASN819 4.1 41.6 1.0 OD1 A:ASP816 4.3 41.6 1.0 O A:GLY180 4.3 47.1 1.0 CB A:ASP409 4.3 34.0 1.0 C A:THR411 4.4 41.6 1.0 C A:GLY180 4.4 47.1 1.0 CG A:ASN819 4.5 41.6 1.0 N A:THR411 4.5 41.6 1.0 NZ A:LYS795 4.5 41.6 1.0 CG A:ASP820 4.6 41.6 1.0 OD1 A:ASP820 4.7 41.6 1.0 OE2 A:GLU837 4.7 59.9 1.0 CB A:THR411 4.7 41.6 1.0 CA A:THR411 4.8 41.6 1.0 O A:ASP179 4.8 47.4 1.0 N A:LYS410 5.0 41.9 1.0

H.Nakanishi, T.Nishizawa, K.Segawa, O.Nureki, Y.Fujiyoshi, S.Nagata, K.Abe. Transport Cycle of Plasma Membrane Flippase ATP11C By Cryo-Em. Cell Rep V. 32 08208 2020.
ISSN: ESSN 2211-1247
PubMed: 32997992
DOI: 10.1016/J.CELREP.2020.108208