Atomistry » Fluorine » PDB 7bj6-7ckn » 7c7n
Atomistry »
  Fluorine »
    PDB 7bj6-7ckn »
      7c7n »

Fluorine in PDB 7c7n: Crystal Structure of E.Coli Dna Gyrase B in Complex with 6-Fluoro-8- (Methylamino)-2-Oxo-1,2-Dihydroquinoline Derivative

Enzymatic activity of Crystal Structure of E.Coli Dna Gyrase B in Complex with 6-Fluoro-8- (Methylamino)-2-Oxo-1,2-Dihydroquinoline Derivative

All present enzymatic activity of Crystal Structure of E.Coli Dna Gyrase B in Complex with 6-Fluoro-8- (Methylamino)-2-Oxo-1,2-Dihydroquinoline Derivative:
5.6.2.2;

Protein crystallography data

The structure of Crystal Structure of E.Coli Dna Gyrase B in Complex with 6-Fluoro-8- (Methylamino)-2-Oxo-1,2-Dihydroquinoline Derivative, PDB code: 7c7n was solved by M.Mima, F.Ushiyama, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 24.49 / 2.30
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 41.333, 67.052, 68.213, 90.00, 90.00, 90.00
R / Rfree (%) 20.6 / 27.6

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Crystal Structure of E.Coli Dna Gyrase B in Complex with 6-Fluoro-8- (Methylamino)-2-Oxo-1,2-Dihydroquinoline Derivative (pdb code 7c7n). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Crystal Structure of E.Coli Dna Gyrase B in Complex with 6-Fluoro-8- (Methylamino)-2-Oxo-1,2-Dihydroquinoline Derivative, PDB code: 7c7n:

Fluorine binding site 1 out of 1 in 7c7n

Go back to Fluorine Binding Sites List in 7c7n
Fluorine binding site 1 out of 1 in the Crystal Structure of E.Coli Dna Gyrase B in Complex with 6-Fluoro-8- (Methylamino)-2-Oxo-1,2-Dihydroquinoline Derivative


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Crystal Structure of E.Coli Dna Gyrase B in Complex with 6-Fluoro-8- (Methylamino)-2-Oxo-1,2-Dihydroquinoline Derivative within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F301

b:25.7
occ:1.00
 F23 A:FKR301 0.0 25.7 1.0
C3 A:FKR301 1.3 25.8 1.0
C4 A:FKR301 2.3 25.9 1.0
C1 A:FKR301 2.3 26.1 1.0
CG2 A:VAL120 3.1 29.8 1.0
C5 A:FKR301 3.5 26.3 1.0
C2 A:FKR301 3.6 26.1 1.0
CB A:VAL120 3.6 29.4 1.0
CG2 A:VAL167 3.9 18.9 1.0
CG1 A:VAL120 3.9 28.1 1.0
CB A:ASN46 4.0 26.9 1.0
C6 A:FKR301 4.1 27.8 1.0
CG A:ASN46 4.2 27.9 1.0
CG1 A:VAL43 4.2 22.0 1.0
SD A:MET95 4.4 27.2 1.0
OD1 A:ASN46 4.5 30.9 1.0
ND2 A:ASN46 4.5 25.6 1.0
O A:VAL43 4.6 20.9 1.0
CA A:VAL43 4.6 21.6 1.0
CB A:VAL167 4.6 18.3 1.0
C8 A:FKR301 4.7 29.1 1.0
CE A:MET95 4.7 26.9 1.0
N24 A:FKR301 4.7 24.9 1.0
CB A:VAL43 4.8 22.2 1.0
CG1 A:VAL167 4.8 17.9 1.0
CG2 A:VAL43 4.9 21.0 1.0

Reference:

F.Ushiyama, H.Amada, Y.Mihara, T.Takeuchi, N.Tanaka-Yamamoto, M.Mima, M.Kamitani, R.Wada, Y.Tamura, M.Endo, A.Masuko, I.Takata, K.Hitaka, H.Sugiyama, N.Ohtake. Lead Optimization of 8-(Methylamino)-2-Oxo-1,2-Dihydroquinolines As Bacterial Type II Topoisomerase Inhibitors. Bioorg.Med.Chem. V. 28 15776 2020.
ISSN: ESSN 1464-3391
PubMed: 33032189
DOI: 10.1016/J.BMC.2020.115776
Page generated: Fri Aug 2 06:07:45 2024

Last articles

Zn in 9JPJ
Zn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy