Fluorine in PDB 7c7q: Cryo-Em Structure of the Baclofen/Bhff-Bound Human Gaba(B) Receptor in Active State

The structure of Cryo-Em Structure of the Baclofen/Bhff-Bound Human Gaba(B) Receptor in Active State also contains other interesting chemical elements:

Chlorine

(Cl)

1 atom

The binding sites of Fluorine atom in the Cryo-Em Structure of the Baclofen/Bhff-Bound Human Gaba(B) Receptor in Active State (pdb code 7c7q). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Cryo-Em Structure of the Baclofen/Bhff-Bound Human Gaba(B) Receptor in Active State, PDB code: 7c7q:
Jump to Fluorine binding site number: 1; 2; 3;

Fluorine binding site 1 out of 3 in the Cryo-Em Structure of the Baclofen/Bhff-Bound Human Gaba(B) Receptor in Active State


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Cryo-Em Structure of the Baclofen/Bhff-Bound Human Gaba(B) Receptor in Active State within 5.0Å range: probe atom residue distance (Å) B Occ A:F1006 b:48.7 occ:1.00 F1 A:FN01006 0.0 48.7 1.0 C17 A:FN01006 1.3 48.7 1.0 F2 A:FN01006 2.1 48.7 1.0 F3 A:FN01006 2.1 48.7 1.0 C7 A:FN01006 2.4 48.7 1.0 C5 A:FN01006 2.9 48.7 1.0 C13 A:FN01006 2.9 48.7 1.0 O1 A:FN01006 3.1 48.7 1.0 C6 A:FN01006 3.3 48.7 1.0 CE B:MET694 3.3 44.5 1.0 O2 A:FN01006 3.5 48.7 1.0 CB B:MET694 3.5 44.5 1.0 CG B:MET694 3.6 44.5 1.0 C9 A:FN01006 3.8 48.7 1.0 O3 A:FN01006 4.0 48.7 1.0 O B:LYS690 4.2 54.5 1.0 SD B:MET694 4.3 44.5 1.0 CD2 B:LEU738 4.4 45.4 1.0 C2 A:FN01006 4.4 48.7 1.0 C B:LYS690 4.7 54.5 1.0 C4 A:FN01006 4.7 48.7 1.0 CD1 B:TYR691 4.7 51.7 1.0 CA B:MET694 4.9 44.5 1.0 C8 A:FN01006 4.9 48.7 1.0

Fluorine binding site 2 out of 3 in the Cryo-Em Structure of the Baclofen/Bhff-Bound Human Gaba(B) Receptor in Active State


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Cryo-Em Structure of the Baclofen/Bhff-Bound Human Gaba(B) Receptor in Active State within 5.0Å range: probe atom residue distance (Å) B Occ A:F1006 b:48.7 occ:1.00 F2 A:FN01006 0.0 48.7 1.0 C17 A:FN01006 1.3 48.7 1.0 F1 A:FN01006 2.1 48.7 1.0 F3 A:FN01006 2.1 48.7 1.0 C7 A:FN01006 2.4 48.7 1.0 C13 A:FN01006 2.6 48.7 1.0 O2 A:FN01006 3.0 48.7 1.0 O3 A:FN01006 3.1 48.7 1.0 CE1 B:TYR691 3.3 51.7 1.0 CD1 B:TYR691 3.3 51.7 1.0 O1 A:FN01006 3.5 48.7 1.0 C5 A:FN01006 3.8 48.7 1.0 CD B:LYS690 4.1 54.5 1.0 CG B:LYS690 4.2 54.5 1.0 C6 A:FN01006 4.2 48.7 1.0 CZ B:TYR691 4.3 51.7 1.0 CG B:TYR691 4.3 51.7 1.0 CB B:LYS690 4.3 54.5 1.0 C B:LYS690 4.4 54.5 1.0 N B:TYR691 4.4 51.7 1.0 O B:LYS690 4.4 54.5 1.0 CE B:LYS690 4.5 54.5 1.0 CA B:TYR691 4.5 51.7 1.0 C9 A:FN01006 4.8 48.7 1.0 OH B:TYR691 4.9 51.7 1.0 NZ B:LYS690 4.9 54.5 1.0 CD2 B:LEU738 4.9 45.4 1.0 NZ A:LYS792 5.0 52.5 1.0 CB B:TYR691 5.0 51.7 1.0 CB B:MET694 5.0 44.5 1.0

Fluorine binding site 3 out of 3 in the Cryo-Em Structure of the Baclofen/Bhff-Bound Human Gaba(B) Receptor in Active State


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Cryo-Em Structure of the Baclofen/Bhff-Bound Human Gaba(B) Receptor in Active State within 5.0Å range: probe atom residue distance (Å) B Occ A:F1006 b:48.7 occ:1.00 F3 A:FN01006 0.0 48.7 1.0 C17 A:FN01006 1.3 48.7 1.0 F1 A:FN01006 2.1 48.7 1.0 F2 A:FN01006 2.1 48.7 1.0 C7 A:FN01006 2.4 48.7 1.0 O2 A:FN01006 2.6 48.7 1.0 C5 A:FN01006 3.4 48.7 1.0 C13 A:FN01006 3.6 48.7 1.0 C9 A:FN01006 3.9 48.7 1.0 CB B:LYS690 3.9 54.5 1.0 CD B:LYS690 4.1 54.5 1.0 CG B:LYS690 4.3 54.5 1.0 O B:LYS690 4.4 54.5 1.0 O1 A:FN01006 4.4 48.7 1.0 C6 A:FN01006 4.4 48.7 1.0 O3 A:FN01006 4.4 48.7 1.0 CE B:MET694 4.4 44.5 1.0 C B:LYS690 4.6 54.5 1.0 CA B:LYS690 4.8 54.5 1.0 CE B:LYS690 5.0 54.5 1.0

C.Mao, C.Shen, C.Li, D.D.Shen, C.Xu, S.Zhang, R.Zhou, Q.Shen, L.N.Chen, Z.Jiang, J.Liu, Y.Zhang. Cryo-Em Structures of Inactive and Active Gababreceptor. Cell Res. V. 30 564 2020.
ISSN: ISSN 1001-0602
PubMed: 32494023
DOI: 10.1038/S41422-020-0350-5