Fluorine in PDB 7cky: Cryo-Em Structure of PW0464 Bound Dopamine Receptor DRD1-Gs Signaling Complex

The binding sites of Fluorine atom in the Cryo-Em Structure of PW0464 Bound Dopamine Receptor DRD1-Gs Signaling Complex (pdb code 7cky). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Cryo-Em Structure of PW0464 Bound Dopamine Receptor DRD1-Gs Signaling Complex, PDB code: 7cky:
Jump to Fluorine binding site number: 1; 2;

Fluorine binding site 1 out of 2 in the Cryo-Em Structure of PW0464 Bound Dopamine Receptor DRD1-Gs Signaling Complex


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Cryo-Em Structure of PW0464 Bound Dopamine Receptor DRD1-Gs Signaling Complex within 5.0Å range: probe atom residue distance (Å) B Occ R:F502 b:46.4 occ:1.00 F01 R:G3U502 0.0 46.4 1.0 C02 R:G3U502 1.4 46.4 1.0 F03 R:G3U502 2.2 46.4 1.0 O04 R:G3U502 2.3 46.4 1.0 OG R:SER198 2.7 47.5 1.0 O R:SER198 3.2 47.5 1.0 CA R:SER199 3.2 41.1 1.0 C R:SER198 3.2 47.5 1.0 N R:SER199 3.2 41.1 1.0 CB R:SER202 3.3 37.8 1.0 C05 R:G3U502 3.3 46.4 1.0 OG R:SER199 3.5 41.1 1.0 OG R:SER202 3.5 37.8 1.0 C06 R:G3U502 3.7 46.4 1.0 CE1 R:PHE289 3.8 41.7 1.0 CB R:SER198 3.8 47.5 1.0 CB R:SER199 3.9 41.1 1.0 CA R:SER198 4.1 47.5 1.0 C R:SER199 4.4 41.1 1.0 C10 R:G3U502 4.5 46.4 1.0 CZ R:PHE289 4.6 41.7 1.0 CD1 R:PHE289 4.7 41.7 1.0 CA R:SER202 4.7 37.8 1.0 CG2 R:ILE154 4.8 50.3 1.0 O R:SER199 4.8 41.1 1.0 O11 R:G3U502 4.9 46.4 1.0

Fluorine binding site 2 out of 2 in the Cryo-Em Structure of PW0464 Bound Dopamine Receptor DRD1-Gs Signaling Complex


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Cryo-Em Structure of PW0464 Bound Dopamine Receptor DRD1-Gs Signaling Complex within 5.0Å range: probe atom residue distance (Å) B Occ R:F502 b:46.4 occ:1.00 F03 R:G3U502 0.0 46.4 1.0 C02 R:G3U502 1.4 46.4 1.0 F01 R:G3U502 2.2 46.4 1.0 O04 R:G3U502 2.3 46.4 1.0 OG R:SER199 2.7 41.1 1.0 OG R:SER198 3.2 47.5 1.0 C05 R:G3U502 3.2 46.4 1.0 OD1 R:ASN292 3.3 48.0 1.0 CD1 R:LEU190 3.4 54.7 1.0 ND2 R:ASN292 3.5 48.0 1.0 CG R:ASN292 3.7 48.0 1.0 N R:SER199 3.7 41.1 1.0 O11 R:G3U502 3.7 46.4 1.0 CB R:SER199 3.7 41.1 1.0 CA R:SER199 3.8 41.1 1.0 C10 R:G3U502 3.9 46.4 1.0 CB R:SER198 4.0 47.5 1.0 C06 R:G3U502 4.2 46.4 1.0 C R:SER198 4.2 47.5 1.0 CE1 R:PHE289 4.3 41.7 1.0 O R:ALA195 4.5 51.9 1.0 O R:SER198 4.7 47.5 1.0 CA R:SER198 4.8 47.5 1.0 CD1 R:PHE289 4.8 41.7 1.0 CG R:LEU190 4.8 54.7 1.0 CB R:ASN292 4.9 48.0 1.0 C12 R:G3U502 5.0 46.4 1.0

P.Xiao, W.Yan, L.Gou, Y.N.Zhong, L.Kong, C.Wu, X.Wen, Y.Yuan, S.Cao, C.Qu, X.Yang, C.C.Yang, A.Xia, Z.Hu, Q.Zhang, Y.H.He, D.L.Zhang, C.Zhang, G.H.Hou, H.Liu, L.Zhu, P.Fu, S.Yang, D.M.Rosenbaum, J.P.Sun, Y.Du, L.Zhang, X.Yu, Z.Shao. Ligand Recognition and Allosteric Regulation of DRD1-Gs Signaling Complexes. Cell V. 184 943 2021.
ISSN: ISSN 1097-4172
PubMed: 33571432
DOI: 10.1016/J.CELL.2021.01.028