Fluorine in PDB 7cr2: Human KCNQ2 in Complex with Retigabine

The binding sites of Fluorine atom in the Human KCNQ2 in Complex with Retigabine (pdb code 7cr2). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 4 binding sites of Fluorine where determined in the Human KCNQ2 in Complex with Retigabine, PDB code: 7cr2:
Jump to Fluorine binding site number: 1; 2; 3; 4;

Fluorine binding site 1 out of 4 in the Human KCNQ2 in Complex with Retigabine


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Human KCNQ2 in Complex with Retigabine within 5.0Å range: probe atom residue distance (Å) B Occ A:F801 b:40.7 occ:1.00 F1 A:FBX801 0.0 40.7 1.0 C19 A:FBX801 1.4 40.7 1.0 C18 A:FBX801 2.3 40.7 1.0 H14 A:FBX801 2.5 40.7 1.0 C17 A:FBX801 2.5 40.7 1.0 H3 A:FBX801 2.7 40.7 1.0 C15 A:FBX801 3.7 40.7 1.0 C16 A:FBX801 3.7 40.7 1.0 C9 A:FBX801 4.2 40.7 1.0 CZ D:PHE104 4.2 98.5 1.0 H13 A:FBX801 4.4 40.7 1.0 H2 A:FBX801 4.4 40.7 1.0 CD1 B:LEU299 4.5 39.0 1.0 CE1 D:PHE104 4.6 98.5 1.0 CD1 A:PHE240 4.6 39.4 1.0 CE1 A:PHE240 4.7 39.4 1.0

Fluorine binding site 2 out of 4 in the Human KCNQ2 in Complex with Retigabine


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Human KCNQ2 in Complex with Retigabine within 5.0Å range: probe atom residue distance (Å) B Occ B:F801 b:40.7 occ:1.00 F1 B:FBX801 0.0 40.7 1.0 C19 B:FBX801 1.4 40.7 1.0 C18 B:FBX801 2.3 40.7 1.0 H14 B:FBX801 2.5 40.7 1.0 C17 B:FBX801 2.5 40.7 1.0 H3 B:FBX801 2.7 40.7 1.0 C15 B:FBX801 3.7 40.7 1.0 C16 B:FBX801 3.7 40.7 1.0 C9 B:FBX801 4.2 40.7 1.0 CZ A:PHE104 4.2 99.4 1.0 H13 B:FBX801 4.4 40.7 1.0 H2 B:FBX801 4.4 40.7 1.0 CD1 C:LEU299 4.5 39.4 1.0 CE1 A:PHE104 4.6 99.4 1.0 CD1 B:PHE240 4.6 39.1 1.0 CE1 B:PHE240 4.7 39.1 1.0

Fluorine binding site 3 out of 4 in the Human KCNQ2 in Complex with Retigabine


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Human KCNQ2 in Complex with Retigabine within 5.0Å range: probe atom residue distance (Å) B Occ C:F801 b:40.5 occ:1.00 F1 C:FBX801 0.0 40.5 1.0 C19 C:FBX801 1.4 40.5 1.0 C18 C:FBX801 2.3 40.5 1.0 H14 C:FBX801 2.5 40.5 1.0 C17 C:FBX801 2.5 40.5 1.0 H3 C:FBX801 2.7 40.5 1.0 C15 C:FBX801 3.7 40.5 1.0 C16 C:FBX801 3.7 40.5 1.0 C9 C:FBX801 4.2 40.5 1.0 CZ B:PHE104 4.2 97.7 1.0 H13 C:FBX801 4.4 40.5 1.0 H2 C:FBX801 4.4 40.5 1.0 CD1 D:LEU299 4.5 39.1 1.0 CD1 C:PHE240 4.6 39.1 1.0 CE1 B:PHE104 4.6 97.7 1.0 CE1 C:PHE240 4.7 39.1 1.0

Fluorine binding site 4 out of 4 in the Human KCNQ2 in Complex with Retigabine


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Human KCNQ2 in Complex with Retigabine within 5.0Å range: probe atom residue distance (Å) B Occ D:F801 b:40.5 occ:1.00 F1 D:FBX801 0.0 40.5 1.0 C19 D:FBX801 1.4 40.5 1.0 C18 D:FBX801 2.3 40.5 1.0 H14 D:FBX801 2.5 40.5 1.0 C17 D:FBX801 2.5 40.5 1.0 H3 D:FBX801 2.7 40.5 1.0 C15 D:FBX801 3.7 40.5 1.0 C16 D:FBX801 3.7 40.5 1.0 C9 D:FBX801 4.2 40.5 1.0 CZ C:PHE104 4.2 97.5 1.0 H13 D:FBX801 4.4 40.5 1.0 H2 D:FBX801 4.4 40.5 1.0 CD1 A:LEU299 4.5 38.9 1.0 CD1 D:PHE240 4.6 39.1 1.0 CE1 C:PHE104 4.6 97.5 1.0 CE1 D:PHE240 4.7 39.1 1.0

X.Li, Q.Zhang, P.Guo, J.Fu, L.Mei, D.Lv, J.Wang, D.Lai, S.Ye, H.Yang, J.Guo. Molecular Basis For Ligand Activation of the Human KCNQ2 Channel. Cell Res. 2020.
ISSN: ISSN 1001-0602
PubMed: 32884139
DOI: 10.1038/S41422-020-00410-8