Fluorine in PDB 7cr2: Human KCNQ2 in Complex with Retigabine

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Human KCNQ2 in Complex with Retigabine (pdb code 7cr2). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 4 binding sites of Fluorine where determined in the Human KCNQ2 in Complex with Retigabine, PDB code: 7cr2:
Jump to Fluorine binding site number: 1; 2; 3; 4;

Fluorine binding site 1 out of 4 in 7cr2

Go back to Fluorine Binding Sites List in 7cr2
Fluorine binding site 1 out of 4 in the Human KCNQ2 in Complex with Retigabine


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Human KCNQ2 in Complex with Retigabine within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F801

b:40.7
occ:1.00
F1 A:FBX801 0.0 40.7 1.0
C19 A:FBX801 1.4 40.7 1.0
C18 A:FBX801 2.3 40.7 1.0
H14 A:FBX801 2.5 40.7 1.0
C17 A:FBX801 2.5 40.7 1.0
H3 A:FBX801 2.7 40.7 1.0
C15 A:FBX801 3.7 40.7 1.0
C16 A:FBX801 3.7 40.7 1.0
C9 A:FBX801 4.2 40.7 1.0
CZ D:PHE104 4.2 98.5 1.0
H13 A:FBX801 4.4 40.7 1.0
H2 A:FBX801 4.4 40.7 1.0
CD1 B:LEU299 4.5 39.0 1.0
CE1 D:PHE104 4.6 98.5 1.0
CD1 A:PHE240 4.6 39.4 1.0
CE1 A:PHE240 4.7 39.4 1.0

Fluorine binding site 2 out of 4 in 7cr2

Go back to Fluorine Binding Sites List in 7cr2
Fluorine binding site 2 out of 4 in the Human KCNQ2 in Complex with Retigabine


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Human KCNQ2 in Complex with Retigabine within 5.0Å range:
probe atom residue distance (Å) B Occ
B:F801

b:40.7
occ:1.00
F1 B:FBX801 0.0 40.7 1.0
C19 B:FBX801 1.4 40.7 1.0
C18 B:FBX801 2.3 40.7 1.0
H14 B:FBX801 2.5 40.7 1.0
C17 B:FBX801 2.5 40.7 1.0
H3 B:FBX801 2.7 40.7 1.0
C15 B:FBX801 3.7 40.7 1.0
C16 B:FBX801 3.7 40.7 1.0
C9 B:FBX801 4.2 40.7 1.0
CZ A:PHE104 4.2 99.4 1.0
H13 B:FBX801 4.4 40.7 1.0
H2 B:FBX801 4.4 40.7 1.0
CD1 C:LEU299 4.5 39.4 1.0
CE1 A:PHE104 4.6 99.4 1.0
CD1 B:PHE240 4.6 39.1 1.0
CE1 B:PHE240 4.7 39.1 1.0

Fluorine binding site 3 out of 4 in 7cr2

Go back to Fluorine Binding Sites List in 7cr2
Fluorine binding site 3 out of 4 in the Human KCNQ2 in Complex with Retigabine


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Human KCNQ2 in Complex with Retigabine within 5.0Å range:
probe atom residue distance (Å) B Occ
C:F801

b:40.5
occ:1.00
F1 C:FBX801 0.0 40.5 1.0
C19 C:FBX801 1.4 40.5 1.0
C18 C:FBX801 2.3 40.5 1.0
H14 C:FBX801 2.5 40.5 1.0
C17 C:FBX801 2.5 40.5 1.0
H3 C:FBX801 2.7 40.5 1.0
C15 C:FBX801 3.7 40.5 1.0
C16 C:FBX801 3.7 40.5 1.0
C9 C:FBX801 4.2 40.5 1.0
CZ B:PHE104 4.2 97.7 1.0
H13 C:FBX801 4.4 40.5 1.0
H2 C:FBX801 4.4 40.5 1.0
CD1 D:LEU299 4.5 39.1 1.0
CD1 C:PHE240 4.6 39.1 1.0
CE1 B:PHE104 4.6 97.7 1.0
CE1 C:PHE240 4.7 39.1 1.0

Fluorine binding site 4 out of 4 in 7cr2

Go back to Fluorine Binding Sites List in 7cr2
Fluorine binding site 4 out of 4 in the Human KCNQ2 in Complex with Retigabine


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Human KCNQ2 in Complex with Retigabine within 5.0Å range:
probe atom residue distance (Å) B Occ
D:F801

b:40.5
occ:1.00
F1 D:FBX801 0.0 40.5 1.0
C19 D:FBX801 1.4 40.5 1.0
C18 D:FBX801 2.3 40.5 1.0
H14 D:FBX801 2.5 40.5 1.0
C17 D:FBX801 2.5 40.5 1.0
H3 D:FBX801 2.7 40.5 1.0
C15 D:FBX801 3.7 40.5 1.0
C16 D:FBX801 3.7 40.5 1.0
C9 D:FBX801 4.2 40.5 1.0
CZ C:PHE104 4.2 97.5 1.0
H13 D:FBX801 4.4 40.5 1.0
H2 D:FBX801 4.4 40.5 1.0
CD1 A:LEU299 4.5 38.9 1.0
CD1 D:PHE240 4.6 39.1 1.0
CE1 C:PHE104 4.6 97.5 1.0
CE1 D:PHE240 4.7 39.1 1.0

Reference:

X.Li, Q.Zhang, P.Guo, J.Fu, L.Mei, D.Lv, J.Wang, D.Lai, S.Ye, H.Yang, J.Guo. Molecular Basis For Ligand Activation of the Human KCNQ2 Channel. Cell Res. 2020.
ISSN: ISSN 1001-0602
PubMed: 32884139
DOI: 10.1038/S41422-020-00410-8
Page generated: Sun Dec 13 13:53:58 2020

Last articles

Zn in 8WB0
Zn in 8WAX
Zn in 8WAU
Zn in 8WAZ
Zn in 8WAY
Zn in 8WAV
Zn in 8WAW
Zn in 8WAT
Zn in 8W7M
Zn in 8WD3
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy