Fluorine in PDB 7cr7: Human KCNQ2-Cam in Complex with Retigabine

The binding sites of Fluorine atom in the Human KCNQ2-Cam in Complex with Retigabine (pdb code 7cr7). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 4 binding sites of Fluorine where determined in the Human KCNQ2-Cam in Complex with Retigabine, PDB code: 7cr7:
Jump to Fluorine binding site number: 1; 2; 3; 4;

Fluorine binding site 1 out of 4 in the Human KCNQ2-Cam in Complex with Retigabine


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Human KCNQ2-Cam in Complex with Retigabine within 5.0Å range: probe atom residue distance (Å) B Occ A:F1001 b:36.0 occ:1.00 F1 A:FBX1001 0.0 36.0 1.0 C19 A:FBX1001 1.4 36.0 1.0 C18 A:FBX1001 2.3 36.0 1.0 C17 A:FBX1001 2.5 36.0 1.0 H14 A:FBX1001 2.5 36.0 1.0 H3 A:FBX1001 2.7 36.0 1.0 C15 A:FBX1001 3.7 36.0 1.0 C16 A:FBX1001 3.7 36.0 1.0 CD1 G:LEU299 4.0 32.4 1.0 CE2 A:PHE240 4.1 35.5 1.0 C9 A:FBX1001 4.2 36.0 1.0 H2 A:FBX1001 4.4 36.0 1.0 H13 A:FBX1001 4.4 36.0 1.0 CD2 A:PHE240 4.5 35.5 1.0 CZ B:PHE104 4.8 0.2 1.0

Fluorine binding site 2 out of 4 in the Human KCNQ2-Cam in Complex with Retigabine


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Human KCNQ2-Cam in Complex with Retigabine within 5.0Å range: probe atom residue distance (Å) B Occ B:F1001 b:32.7 occ:1.00 F1 B:FBX1001 0.0 32.7 1.0 C19 B:FBX1001 1.4 32.7 1.0 C18 B:FBX1001 2.3 32.7 1.0 C17 B:FBX1001 2.5 32.7 1.0 H14 B:FBX1001 2.5 32.7 1.0 H3 B:FBX1001 2.7 32.7 1.0 C15 B:FBX1001 3.7 32.7 1.0 C16 B:FBX1001 3.7 32.7 1.0 CE2 B:PHE240 4.1 36.6 1.0 C9 B:FBX1001 4.2 32.7 1.0 CD1 A:LEU299 4.3 32.1 1.0 H2 B:FBX1001 4.4 32.7 1.0 H13 B:FBX1001 4.4 32.7 1.0 CD2 B:PHE240 4.5 36.6 1.0 CZ D:PHE104 4.8 0.5 1.0

Fluorine binding site 3 out of 4 in the Human KCNQ2-Cam in Complex with Retigabine


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Human KCNQ2-Cam in Complex with Retigabine within 5.0Å range: probe atom residue distance (Å) B Occ D:F1001 b:34.8 occ:1.00 F1 D:FBX1001 0.0 34.8 1.0 C19 D:FBX1001 1.4 34.8 1.0 C18 D:FBX1001 2.3 34.8 1.0 C17 D:FBX1001 2.5 34.8 1.0 H14 D:FBX1001 2.5 34.8 1.0 H3 D:FBX1001 2.7 34.8 1.0 C15 D:FBX1001 3.7 34.8 1.0 C16 D:FBX1001 3.7 34.8 1.0 CE2 D:PHE240 4.1 35.2 1.0 CD1 B:LEU299 4.1 32.0 1.0 C9 D:FBX1001 4.2 34.8 1.0 H2 D:FBX1001 4.4 34.8 1.0 H13 D:FBX1001 4.4 34.8 1.0 CD2 D:PHE240 4.5 35.2 1.0 CZ G:PHE104 4.9 0.6 1.0

Fluorine binding site 4 out of 4 in the Human KCNQ2-Cam in Complex with Retigabine


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Human KCNQ2-Cam in Complex with Retigabine within 5.0Å range: probe atom residue distance (Å) B Occ G:F1001 b:32.0 occ:1.00 F1 G:FBX1001 0.0 32.0 1.0 C19 G:FBX1001 1.4 32.0 1.0 C18 G:FBX1001 2.3 32.0 1.0 C17 G:FBX1001 2.5 32.0 1.0 H14 G:FBX1001 2.5 32.0 1.0 H3 G:FBX1001 2.7 32.0 1.0 C15 G:FBX1001 3.7 32.0 1.0 C16 G:FBX1001 3.7 32.0 1.0 CE2 G:PHE240 4.1 34.9 1.0 CD1 D:LEU299 4.2 32.7 1.0 C9 G:FBX1001 4.2 32.0 1.0 H2 G:FBX1001 4.4 32.0 1.0 H13 G:FBX1001 4.4 32.0 1.0 CD2 G:PHE240 4.5 34.9 1.0 CZ A:PHE104 4.9 0.6 1.0

X.Li, Q.Zhang, P.Guo, J.Fu, L.Mei, D.Lv, J.Wang, D.Lai, S.Ye, H.Yang, J.Guo. Molecular Basis For Ligand Activation of the Human KCNQ2 Channel. Cell Res. 2020.
ISSN: ISSN 1001-0602
PubMed: 32884139
DOI: 10.1038/S41422-020-00410-8