Fluorine in PDB 7ctz: Wild-Type Plasmodium Falciparum Dihydrofolate Reductase-Thymidylate Synthase (Pfdhfr-Ts) Complexed with Fragment 148, Nadph, and Dump

The structure of Wild-Type Plasmodium Falciparum Dihydrofolate Reductase-Thymidylate Synthase (Pfdhfr-Ts) Complexed with Fragment 148, Nadph, and Dump, PDB code: 7ctz was solved by D.Vitsupakorn, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	24.83 / 2.65
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	56.638, 155.639, 164.614, 90, 90, 90
R / Rfree (%)	25.5 / 32.5

The binding sites of Fluorine atom in the Wild-Type Plasmodium Falciparum Dihydrofolate Reductase-Thymidylate Synthase (Pfdhfr-Ts) Complexed with Fragment 148, Nadph, and Dump (pdb code 7ctz). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 6 binding sites of Fluorine where determined in the Wild-Type Plasmodium Falciparum Dihydrofolate Reductase-Thymidylate Synthase (Pfdhfr-Ts) Complexed with Fragment 148, Nadph, and Dump, PDB code: 7ctz:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6;

Fluorine binding site 1 out of 6 in the Wild-Type Plasmodium Falciparum Dihydrofolate Reductase-Thymidylate Synthase (Pfdhfr-Ts) Complexed with Fragment 148, Nadph, and Dump


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Wild-Type Plasmodium Falciparum Dihydrofolate Reductase-Thymidylate Synthase (Pfdhfr-Ts) Complexed with Fragment 148, Nadph, and Dump within 5.0Å range: probe atom residue distance (Å) B Occ A:F703 b:33.8 occ:0.60 F1 A:GF6703 0.0 33.8 0.6 O1 A:GF6703 0.8 28.0 0.4 C7 A:GF6703 1.3 32.5 0.6 C1 A:GF6703 1.9 27.7 0.4 F2 A:GF6703 2.1 36.5 0.6 F3 A:GF6703 2.2 29.1 0.6 C6 A:GF6703 2.4 30.4 0.6 H7 A:GF6703 2.6 31.1 0.6 H7 A:GF6703 2.6 35.0 0.4 HD1 A:PHE58 2.6 15.7 1.0 HA A:CYS15 2.6 16.3 1.0 HG12 A:ILE14 2.7 17.1 1.0 N2 A:GF6703 2.7 28.9 0.4 C8 A:GF6703 2.8 31.1 0.6 N1 A:GF6703 3.0 24.4 0.4 HE1 A:PHE58 3.1 15.8 1.0 C8 A:GF6703 3.1 35.0 0.4 H2 A:GF6703 3.1 24.4 0.0 CD1 A:PHE58 3.1 15.7 1.0 HG23 A:ILE14 3.2 18.1 1.0 C2 A:GF6703 3.2 31.8 0.4 CA A:CYS15 3.3 16.3 1.0 N A:CYS15 3.3 16.6 1.0 CE1 A:PHE58 3.4 15.8 1.0 C A:ILE14 3.4 17.5 1.0 H3 A:GF6703 3.5 28.9 0.4 O A:ILE14 3.5 17.8 1.0 C5 A:GF6703 3.6 29.6 0.6 CG1 A:ILE14 3.6 17.1 1.0 H1 A:GF6703 3.6 38.9 0.0 C A:CYS15 3.7 17.0 1.0 H1 A:GF6703 3.8 24.4 0.0 H A:CYS15 3.8 16.6 1.0 H6 A:GF6703 3.9 29.6 0.6 O A:CYS15 3.9 15.6 1.0 O7N A:NDP701 3.9 18.5 1.0 HD13 A:ILE14 3.9 18.5 1.0 CG2 A:ILE14 4.0 18.1 1.0 CB A:ILE14 4.2 17.5 1.0 C2 A:GF6703 4.2 33.1 0.6 CD1 A:ILE14 4.2 18.5 1.0 HB2 A:PHE58 4.2 18.6 1.0 CG A:PHE58 4.2 16.9 1.0 HH A:TYR170 4.2 17.5 0.0 HG13 A:ILE14 4.3 17.1 1.0 F1 A:GF6703 4.3 47.3 0.4 HD12 A:ILE14 4.3 18.5 1.0 HG22 A:ILE14 4.3 18.1 1.0 OH A:TYR170 4.3 17.5 1.0 C6 A:GF6703 4.3 39.4 0.4 N A:ALA16 4.3 18.3 1.0 CA A:ILE14 4.4 17.4 1.0 H42N A:NDP701 4.4 21.3 1.0 H A:ALA16 4.4 18.3 1.0 C3 A:GF6703 4.5 34.0 0.4 HB2 A:ALA16 4.5 17.8 1.0 N1 A:GF6703 4.5 38.9 0.6 CZ A:PHE58 4.6 15.8 1.0 CB A:CYS15 4.7 17.1 1.0 C4 A:GF6703 4.7 30.8 0.6 HA A:ILE164 4.7 15.1 1.0 HG21 A:ILE14 4.8 18.1 1.0 HB A:ILE164 4.8 14.9 1.0 CB A:PHE58 4.8 18.6 1.0 HB3 A:CYS15 4.9 17.1 1.0 H4 A:GF6703 4.9 34.0 0.4 HA A:ILE14 4.9 17.4 1.0 H2 A:GF6703 4.9 38.9 0.0 C7 A:GF6703 4.9 44.6 0.4 H41N A:NDP701 4.9 21.3 1.0 HB3 A:ALA16 4.9 17.8 1.0 HB2 A:CYS15 4.9 17.1 1.0 C3 A:GF6703 4.9 34.2 0.6

Fluorine binding site 2 out of 6 in the Wild-Type Plasmodium Falciparum Dihydrofolate Reductase-Thymidylate Synthase (Pfdhfr-Ts) Complexed with Fragment 148, Nadph, and Dump


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Wild-Type Plasmodium Falciparum Dihydrofolate Reductase-Thymidylate Synthase (Pfdhfr-Ts) Complexed with Fragment 148, Nadph, and Dump within 5.0Å range: probe atom residue distance (Å) B Occ A:F703 b:47.3 occ:0.40 F1 A:GF6703 0.0 47.3 0.4 N1 A:GF6703 0.7 38.9 0.6 H1 A:GF6703 0.9 38.9 0.0 C7 A:GF6703 1.3 44.6 0.4 C1 A:GF6703 1.4 37.0 0.6 H2 A:GF6703 1.4 38.9 0.0 H7 A:GF6703 2.0 31.1 0.6 N2 A:GF6703 2.0 34.6 0.6 F2 A:GF6703 2.1 52.9 0.4 F3 A:GF6703 2.1 46.4 0.4 H42N A:NDP701 2.3 21.3 1.0 C6 A:GF6703 2.3 39.4 0.4 O1 A:GF6703 2.4 31.2 0.6 H7 A:GF6703 2.4 35.0 0.4 C2 A:GF6703 2.5 33.1 0.6 C8 A:GF6703 2.5 31.1 0.6 C8 A:GF6703 2.7 35.0 0.4 H3 A:GF6703 2.8 34.6 0.6 H5N A:NDP701 2.8 20.6 1.0 O A:ILE164 2.9 16.8 1.0 C4N A:NDP701 3.1 21.3 1.0 C5N A:NDP701 3.2 20.6 1.0 HB A:ILE164 3.3 14.9 1.0 H41N A:NDP701 3.5 21.3 1.0 C5 A:GF6703 3.6 37.8 0.4 C3 A:GF6703 3.8 34.2 0.6 C6 A:GF6703 3.8 30.4 0.6 H6 A:GF6703 3.9 37.8 0.4 HD11 A:ILE164 3.9 15.4 1.0 C A:ILE164 4.1 16.8 1.0 HG13 A:ILE164 4.1 15.4 1.0 C2 A:GF6703 4.1 31.8 0.4 CB A:ILE164 4.1 14.9 1.0 HH A:TYR170 4.2 17.5 0.0 HE1 A:PHE58 4.2 15.8 1.0 C3N A:NDP701 4.2 20.4 1.0 HZ A:PHE58 4.2 15.8 1.0 H4 A:GF6703 4.3 34.2 0.6 F1 A:GF6703 4.3 33.8 0.6 CE1 A:PHE58 4.3 15.8 1.0 C6N A:NDP701 4.3 20.6 1.0 CZ A:PHE58 4.3 15.8 1.0 CG1 A:ILE164 4.5 15.4 1.0 CA A:ILE164 4.5 15.1 1.0 O7N A:NDP701 4.5 18.5 1.0 HA A:ILE164 4.6 15.1 1.0 C7 A:GF6703 4.6 32.5 0.6 CD1 A:ILE164 4.7 15.4 1.0 O A:HOH812 4.7 21.2 1.0 OH A:TYR170 4.7 17.5 1.0 C4 A:GF6703 4.7 35.7 0.4 H6N A:NDP701 4.8 20.6 1.0 C7N A:NDP701 4.8 19.7 1.0 O1 A:GF6703 4.8 28.0 0.4 C4 A:GF6703 4.8 30.8 0.6 C5 A:GF6703 4.8 29.6 0.6 C3 A:GF6703 4.9 34.0 0.4 HB3 A:SER108 4.9 20.7 1.0 HA3 A:GLY165 5.0 18.6 1.0

Fluorine binding site 3 out of 6 in the Wild-Type Plasmodium Falciparum Dihydrofolate Reductase-Thymidylate Synthase (Pfdhfr-Ts) Complexed with Fragment 148, Nadph, and Dump


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Wild-Type Plasmodium Falciparum Dihydrofolate Reductase-Thymidylate Synthase (Pfdhfr-Ts) Complexed with Fragment 148, Nadph, and Dump within 5.0Å range: probe atom residue distance (Å) B Occ A:F703 b:36.5 occ:0.60 F2 A:GF6703 0.0 36.5 0.6 C7 A:GF6703 1.3 32.5 0.6 C1 A:GF6703 1.7 27.7 0.4 O1 A:GF6703 1.7 28.0 0.4 N2 A:GF6703 2.0 28.9 0.4 F3 A:GF6703 2.1 29.1 0.6 F1 A:GF6703 2.1 33.8 0.6 HA A:CYS15 2.2 16.3 1.0 H3 A:GF6703 2.2 28.9 0.4 C6 A:GF6703 2.3 30.4 0.6 C A:CYS15 2.3 17.0 1.0 N A:ALA16 2.5 18.3 1.0 HB2 A:ALA16 2.6 17.8 1.0 N1 A:GF6703 2.7 24.4 0.4 CA A:CYS15 2.7 16.3 1.0 H A:ALA16 2.7 18.3 1.0 O7N A:NDP701 2.7 18.5 1.0 O A:CYS15 2.8 15.6 1.0 H7 A:GF6703 2.9 35.0 0.4 HB3 A:ALA16 2.9 17.8 1.0 C2 A:GF6703 3.0 31.8 0.4 CB A:ALA16 3.1 17.8 1.0 H2 A:GF6703 3.1 24.4 0.0 C5 A:GF6703 3.1 29.6 0.6 C8 A:GF6703 3.1 31.1 0.6 H7 A:GF6703 3.1 31.1 0.6 H6 A:GF6703 3.1 29.6 0.6 H1 A:GF6703 3.2 24.4 0.0 C8 A:GF6703 3.3 35.0 0.4 CA A:ALA16 3.3 17.8 1.0 N A:CYS15 3.5 16.6 1.0 C7N A:NDP701 3.8 19.7 1.0 HA A:ALA16 3.8 17.8 1.0 H A:CYS15 3.9 16.6 1.0 HG12 A:ILE14 3.9 17.1 1.0 CB A:CYS15 4.0 17.1 1.0 HB2 A:CYS15 4.0 17.1 1.0 HB1 A:ALA16 4.0 17.8 1.0 H72N A:NDP701 4.2 19.6 0.0 C A:ILE14 4.2 17.5 1.0 C4 A:GF6703 4.3 30.8 0.6 C3 A:GF6703 4.3 34.0 0.4 H42N A:NDP701 4.3 21.3 1.0 C2 A:GF6703 4.3 33.1 0.6 HD1 A:PHE58 4.4 15.7 1.0 O A:ILE14 4.4 17.8 1.0 N7N A:NDP701 4.5 19.6 1.0 C A:ALA16 4.5 16.6 1.0 OD2 A:ASP54 4.5 21.2 1.0 HB A:THR185 4.5 17.5 1.0 HB3 A:CYS15 4.5 17.1 1.0 O A:ALA16 4.5 16.4 1.0 H4 A:GF6703 4.6 34.0 0.4 OH A:TYR170 4.6 17.5 1.0 C6 A:GF6703 4.7 39.4 0.4 H1 A:GF6703 4.7 38.9 0.0 OD1 A:ASP54 4.8 17.4 1.0 H41N A:NDP701 4.8 21.3 1.0 HG1 A:THR185 4.8 17.8 0.0 C3 A:GF6703 4.8 34.2 0.6 C3N A:NDP701 4.8 20.4 1.0 C4N A:NDP701 4.8 21.3 1.0 HH A:TYR170 4.9 17.5 0.0 CG1 A:ILE14 4.9 17.1 1.0 CD1 A:PHE58 5.0 15.7 1.0 H5 A:GF6703 5.0 30.8 0.6

Fluorine binding site 4 out of 6 in the Wild-Type Plasmodium Falciparum Dihydrofolate Reductase-Thymidylate Synthase (Pfdhfr-Ts) Complexed with Fragment 148, Nadph, and Dump


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Wild-Type Plasmodium Falciparum Dihydrofolate Reductase-Thymidylate Synthase (Pfdhfr-Ts) Complexed with Fragment 148, Nadph, and Dump within 5.0Å range: probe atom residue distance (Å) B Occ A:F703 b:52.9 occ:0.40 F2 A:GF6703 0.0 52.9 0.4 C1 A:GF6703 1.1 37.0 0.6 C7 A:GF6703 1.3 44.6 0.4 O1 A:GF6703 1.6 31.2 0.6 N1 A:GF6703 1.8 38.9 0.6 N2 A:GF6703 1.9 34.6 0.6 F3 A:GF6703 2.1 46.4 0.4 F1 A:GF6703 2.1 47.3 0.4 H2 A:GF6703 2.2 38.9 0.0 H1 A:GF6703 2.3 38.9 0.0 H3 A:GF6703 2.3 34.6 0.6 C6 A:GF6703 2.3 39.4 0.4 H6 A:GF6703 2.6 37.8 0.4 C5 A:GF6703 2.8 37.8 0.4 C2 A:GF6703 2.8 33.1 0.6 O A:HOH823 3.4 21.0 1.0 C8 A:GF6703 3.5 35.0 0.4 C8 A:GF6703 3.6 31.1 0.6 H7 A:GF6703 3.6 31.1 0.6 HD11 A:ILE164 3.6 15.4 1.0 C3 A:GF6703 3.7 34.2 0.6 H4 A:GF6703 3.7 34.2 0.6 HD12 A:ILE112 3.8 32.7 1.0 H7 A:GF6703 3.8 35.0 0.4 H42N A:NDP701 4.1 21.3 1.0 O A:HOH812 4.1 21.2 1.0 HD13 A:ILE112 4.1 32.7 1.0 C4 A:GF6703 4.1 35.7 0.4 H5N A:NDP701 4.2 20.6 1.0 HZ A:PHE58 4.2 15.8 1.0 HG12 A:ILE112 4.3 31.1 1.0 HB A:ILE164 4.3 14.9 1.0 CZ A:PHE58 4.3 15.8 1.0 CD1 A:ILE112 4.4 32.7 1.0 HD12 A:LEU119 4.4 24.4 1.0 CE2 A:PHE58 4.5 15.6 1.0 CD1 A:ILE164 4.5 15.4 1.0 HE2 A:PHE58 4.6 15.6 1.0 C5N A:NDP701 4.6 20.6 1.0 O A:ILE164 4.7 16.8 1.0 HG13 A:ILE164 4.7 15.4 1.0 C2 A:GF6703 4.7 31.8 0.4 H5 A:GF6703 4.7 35.7 0.4 C6 A:GF6703 4.8 30.4 0.6 HD12 A:ILE164 4.9 15.4 1.0 C4N A:NDP701 4.9 21.3 1.0 CE1 A:PHE58 4.9 15.8 1.0 CG1 A:ILE112 4.9 31.1 1.0 C4 A:GF6703 4.9 30.8 0.6 C3 A:GF6703 4.9 34.0 0.4 HB3 A:SER108 4.9 20.7 1.0 CG1 A:ILE164 5.0 15.4 1.0

Fluorine binding site 5 out of 6 in the Wild-Type Plasmodium Falciparum Dihydrofolate Reductase-Thymidylate Synthase (Pfdhfr-Ts) Complexed with Fragment 148, Nadph, and Dump


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 5 of Wild-Type Plasmodium Falciparum Dihydrofolate Reductase-Thymidylate Synthase (Pfdhfr-Ts) Complexed with Fragment 148, Nadph, and Dump within 5.0Å range: probe atom residue distance (Å) B Occ A:F703 b:29.1 occ:0.60 F3 A:GF6703 0.0 29.1 0.6 C1 A:GF6703 0.5 27.7 0.4 N1 A:GF6703 0.9 24.4 0.4 C7 A:GF6703 1.4 32.5 0.6 H2 A:GF6703 1.4 24.4 0.0 O1 A:GF6703 1.5 28.0 0.4 H1 A:GF6703 1.6 24.4 0.0 N2 A:GF6703 1.8 28.9 0.4 F2 A:GF6703 2.1 36.5 0.6 F1 A:GF6703 2.2 33.8 0.6 H3 A:GF6703 2.3 28.9 0.4 C6 A:GF6703 2.4 30.4 0.6 H6 A:GF6703 2.5 29.6 0.6 C5 A:GF6703 2.8 29.6 0.6 C2 A:GF6703 2.9 31.8 0.4 HD1 A:PHE58 3.0 15.7 1.0 HB2 A:ALA16 3.1 17.8 1.0 HG12 A:ILE14 3.2 17.1 1.0 HB2 A:PHE58 3.2 18.6 1.0 O A:CYS15 3.3 15.6 1.0 OD1 A:ASP54 3.4 17.4 1.0 C A:CYS15 3.6 17.0 1.0 H7 A:GF6703 3.6 35.0 0.4 C8 A:GF6703 3.6 31.1 0.6 C8 A:GF6703 3.7 35.0 0.4 CD1 A:PHE58 3.7 15.7 1.0 HG1 A:THR185 3.7 17.8 0.0 OD2 A:ASP54 3.8 21.2 1.0 HA A:CYS15 3.8 16.3 1.0 C3 A:GF6703 3.8 34.0 0.4 H4 A:GF6703 3.8 34.0 0.4 HD12 A:ILE14 3.9 18.5 1.0 H7 A:GF6703 3.9 31.1 0.6 CG A:ASP54 3.9 20.1 1.0 CB A:ALA16 4.0 17.8 1.0 CG1 A:ILE14 4.1 17.1 1.0 CB A:PHE58 4.1 18.6 1.0 HB3 A:ALA16 4.1 17.8 1.0 CA A:CYS15 4.1 16.3 1.0 N A:ALA16 4.1 18.3 1.0 C4 A:GF6703 4.2 30.8 0.6 N A:CYS15 4.2 16.6 1.0 CG A:PHE58 4.3 16.9 1.0 H A:CYS15 4.3 16.6 1.0 OG1 A:THR185 4.3 17.8 1.0 HD13 A:ILE14 4.3 18.5 1.0 CD1 A:ILE14 4.3 18.5 1.0 HG13 A:ILE14 4.4 17.1 1.0 HD2 A:TYR57 4.4 17.9 1.0 HB A:THR185 4.4 17.5 1.0 HA A:PHE58 4.5 19.6 1.0 CA A:ALA16 4.6 17.8 1.0 CE1 A:PHE58 4.6 15.8 1.0 H A:ALA16 4.6 18.3 1.0 HE1 A:PHE58 4.6 15.8 1.0 HB1 A:ALA16 4.7 17.8 1.0 HB3 A:PHE58 4.7 18.6 1.0 H5 A:GF6703 4.7 30.8 0.6 O7N A:NDP701 4.7 18.5 1.0 O A:ASP54 4.7 18.6 1.0 HA A:ALA16 4.8 17.8 1.0 C2 A:GF6703 4.8 33.1 0.6 C A:ILE14 4.8 17.5 1.0 HG23 A:ILE14 4.9 18.1 1.0 CA A:PHE58 4.9 19.6 1.0 CB A:THR185 4.9 17.5 1.0 C6 A:GF6703 5.0 39.4 0.4 C3 A:GF6703 5.0 34.2 0.6

Fluorine binding site 6 out of 6 in the Wild-Type Plasmodium Falciparum Dihydrofolate Reductase-Thymidylate Synthase (Pfdhfr-Ts) Complexed with Fragment 148, Nadph, and Dump


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 6 of Wild-Type Plasmodium Falciparum Dihydrofolate Reductase-Thymidylate Synthase (Pfdhfr-Ts) Complexed with Fragment 148, Nadph, and Dump within 5.0Å range: probe atom residue distance (Å) B Occ A:F703 b:46.4 occ:0.40 F3 A:GF6703 0.0 46.4 0.4 H3 A:GF6703 1.0 34.6 0.6 N2 A:GF6703 1.0 34.6 0.6 C1 A:GF6703 1.3 37.0 0.6 C7 A:GF6703 1.3 44.6 0.4 O1 A:GF6703 1.8 31.2 0.6 F2 A:GF6703 2.1 52.9 0.4 F1 A:GF6703 2.1 47.3 0.4 C2 A:GF6703 2.3 33.1 0.6 C6 A:GF6703 2.3 39.4 0.4 N1 A:GF6703 2.5 38.9 0.6 O A:HOH812 2.6 21.2 1.0 H42N A:NDP701 2.7 21.3 1.0 H1 A:GF6703 2.8 38.9 0.0 C5N A:NDP701 3.1 20.6 1.0 H5N A:NDP701 3.1 20.6 1.0 H6 A:GF6703 3.1 37.8 0.4 C5 A:GF6703 3.1 37.8 0.4 H2 A:GF6703 3.1 38.9 0.0 H4 A:GF6703 3.2 34.2 0.6 C3 A:GF6703 3.3 34.2 0.6 C8 A:GF6703 3.3 35.0 0.4 C8 A:GF6703 3.3 31.1 0.6 H7 A:GF6703 3.3 31.1 0.6 C4N A:NDP701 3.3 21.3 1.0 H7 A:GF6703 3.4 35.0 0.4 C6N A:NDP701 3.6 20.6 1.0 HD22 A:LEU46 3.8 24.6 1.0 C3N A:NDP701 3.9 20.4 1.0 H6N A:NDP701 3.9 20.6 1.0 HO2N A:NDP701 4.0 27.8 0.0 H41N A:NDP701 4.1 21.3 1.0 N1N A:NDP701 4.2 22.1 1.0 C2N A:NDP701 4.3 21.7 1.0 C4 A:GF6703 4.3 35.7 0.4 O A:HOH823 4.5 21.0 1.0 C2 A:GF6703 4.5 31.8 0.4 HD12 A:LEU46 4.5 21.3 1.0 O A:ILE164 4.5 16.8 1.0 HB3 A:SER108 4.5 20.7 1.0 C4 A:GF6703 4.6 30.8 0.6 C6 A:GF6703 4.6 30.4 0.6 C7N A:NDP701 4.7 19.7 1.0 CD2 A:LEU46 4.7 24.6 1.0 HG A:SER111 4.9 30.4 0.0 O2D A:NDP701 4.9 27.8 1.0 C3 A:GF6703 4.9 34.0 0.4 HG A:LEU46 4.9 23.7 1.0 H2D A:NDP701 5.0 24.9 1.0 HG12 A:ILE112 5.0 31.1 1.0 O7N A:NDP701 5.0 18.5 1.0

M.Hoarau, J.Vanichtanankul, N.Srimongkolpithak, D.Vitsupakorn, Y.Yuthavong, S.Kamchonwongpaisan. Discovery of New Non-Pyrimidine Scaffolds As Plasmodium Falciparum Dhfr Inhibitors By Fragment-Based Screening. J Enzyme Inhib Med Chem V. 36 198 2021.
ISSN: ESSN 1475-6374
PubMed: 33530764
DOI: 10.1080/14756366.2020.1854244