Fluorine in PDB 7d8x: Cryoem Structure of Human Gamma-Secretase in Complex with E2012 and L685458

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Cryoem Structure of Human Gamma-Secretase in Complex with E2012 and L685458 (pdb code 7d8x). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Cryoem Structure of Human Gamma-Secretase in Complex with E2012 and L685458, PDB code: 7d8x:

Fluorine binding site 1 out of 1 in 7d8x

Go back to Fluorine Binding Sites List in 7d8x
Fluorine binding site 1 out of 1 in the Cryoem Structure of Human Gamma-Secretase in Complex with E2012 and L685458


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Cryoem Structure of Human Gamma-Secretase in Complex with E2012 and L685458 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:F502

b:56.4
occ:1.00
F01 B:GZR502 0.0 56.4 1.0
C25 B:GZR502 1.4 56.4 1.0
C22 B:GZR502 2.5 56.4 1.0
C21 B:GZR502 2.5 56.4 1.0
C18 B:GZR502 3.8 56.4 1.0
C17 B:GZR502 3.9 56.4 1.0
C13 B:GZR502 4.4 56.4 1.0

Reference:

G.Yang, R.Zhou, X.Guo, C.Yan, J.Lei, Y.Shi. Structural Basis of Gamma-Secretase Inhibition and Modulation By Small Molecule Drugs. Cell 2020.
ISSN: ISSN 1097-4172
PubMed: 33373587
DOI: 10.1016/J.CELL.2020.11.049
Page generated: Wed Mar 3 13:33:36 2021

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