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Fluorine in PDB 7db8: Crystal Structure of Mycobacterium Tuberculosis Phenylalanyl-Trna Synthetase in Complex with Compound Pf-3845Enzymatic activity of Crystal Structure of Mycobacterium Tuberculosis Phenylalanyl-Trna Synthetase in Complex with Compound Pf-3845
All present enzymatic activity of Crystal Structure of Mycobacterium Tuberculosis Phenylalanyl-Trna Synthetase in Complex with Compound Pf-3845:
6.1.1.20; Protein crystallography data
The structure of Crystal Structure of Mycobacterium Tuberculosis Phenylalanyl-Trna Synthetase in Complex with Compound Pf-3845, PDB code: 7db8
was solved by
M.Xu,
X.Zhang,
L.Xu,
S.Chen,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Mycobacterium Tuberculosis Phenylalanyl-Trna Synthetase in Complex with Compound Pf-3845
(pdb code 7db8). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Crystal Structure of Mycobacterium Tuberculosis Phenylalanyl-Trna Synthetase in Complex with Compound Pf-3845, PDB code: 7db8: Jump to Fluorine binding site number: 1; 2; 3; Fluorine binding site 1 out of 3 in 7db8Go back to Fluorine Binding Sites List in 7db8
Fluorine binding site 1 out
of 3 in the Crystal Structure of Mycobacterium Tuberculosis Phenylalanyl-Trna Synthetase in Complex with Compound Pf-3845
Mono view Stereo pair view
Fluorine binding site 2 out of 3 in 7db8Go back to Fluorine Binding Sites List in 7db8
Fluorine binding site 2 out
of 3 in the Crystal Structure of Mycobacterium Tuberculosis Phenylalanyl-Trna Synthetase in Complex with Compound Pf-3845
Mono view Stereo pair view
Fluorine binding site 3 out of 3 in 7db8Go back to Fluorine Binding Sites List in 7db8
Fluorine binding site 3 out
of 3 in the Crystal Structure of Mycobacterium Tuberculosis Phenylalanyl-Trna Synthetase in Complex with Compound Pf-3845
Mono view Stereo pair view
Reference:
H.Wang,
M.Xu,
C.A.Engelhart,
X.Zhang,
B.Yan,
M.Pan,
Y.Xu,
S.Fan,
R.Liu,
L.Xu,
L.Hua,
D.Schnappinger,
S.Chen.
Re-Discovery of Pf-3845 As A New Chemical Scaffold Inhibiting Phenylalanyl-Trna Synthetase in Mycobacterium Tuberculosis . J.Biol.Chem. 2021.
Page generated: Sun Jan 24 15:58:15 2021
ISSN: ESSN 1083-351X PubMed: 33397709 DOI: 10.1074/JBC.RA120.016477 |
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