Fluorine in PDB 7dfz: CRYO_EM Structure of Delta N-NPC1L1-Eze

Fluorine Binding Sites:

The binding sites of Fluorine atom in the CRYO_EM Structure of Delta N-NPC1L1-Eze (pdb code 7dfz). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the CRYO_EM Structure of Delta N-NPC1L1-Eze, PDB code: 7dfz:
Jump to Fluorine binding site number: 1; 2;

Fluorine binding site 1 out of 2 in 7dfz

Go back to Fluorine Binding Sites List in 7dfz
Fluorine binding site 1 out of 2 in the CRYO_EM Structure of Delta N-NPC1L1-Eze


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of CRYO_EM Structure of Delta N-NPC1L1-Eze within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F1306

b:85.0
occ:1.00
F1 A:H561306 0.0 85.0 1.0
C6 A:H561306 1.4 85.0 1.0
C7 A:H561306 2.3 85.0 1.0
C5 A:H561306 2.5 85.0 1.0
H7 A:H561306 2.6 85.0 1.0
H5 A:H561306 2.8 85.0 1.0
OE1 A:GLN873 3.1 90.2 1.0
CD2 A:PHE1101 3.3 90.2 1.0
CE2 A:PHE1101 3.5 90.2 1.0
C4 A:H561306 3.7 85.0 1.0
C8 A:H561306 3.7 85.0 1.0
CD A:GLN873 3.9 90.2 1.0
CG A:GLN873 4.0 90.2 1.0
OH A:TYR1102 4.1 90.2 1.0
C3 A:H561306 4.2 85.0 1.0
CG A:PHE1101 4.2 90.2 1.0
CZ A:PHE1101 4.6 90.2 1.0
H8 A:H561306 4.6 85.0 1.0
H4 A:H561306 4.6 85.0 1.0
CZ A:TYR1102 4.7 90.2 1.0
CB A:GLN873 4.7 90.2 1.0
CB A:PHE1101 4.8 90.2 1.0
CE2 A:TYR1102 4.9 90.2 1.0

Fluorine binding site 2 out of 2 in 7dfz

Go back to Fluorine Binding Sites List in 7dfz
Fluorine binding site 2 out of 2 in the CRYO_EM Structure of Delta N-NPC1L1-Eze


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of CRYO_EM Structure of Delta N-NPC1L1-Eze within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F1306

b:85.0
occ:1.00
F2 A:H561306 0.0 85.0 1.0
C16 A:H561306 1.4 85.0 1.0
C15 A:H561306 2.3 85.0 1.0
C17 A:H561306 2.5 85.0 1.0
H15 A:H561306 2.6 85.0 1.0
H17 A:H561306 2.8 85.0 1.0
CZ A:PHE1239 3.2 77.4 1.0
CE2 A:PHE1239 3.3 77.4 1.0
CG2 A:VAL1166 3.6 90.2 1.0
C18 A:H561306 3.7 85.0 1.0
C14 A:H561306 3.7 85.0 1.0
C13 A:H561306 4.2 85.0 1.0
CG1 A:VAL701 4.4 92.4 1.0
CE1 A:PHE1239 4.4 77.4 1.0
CD2 A:PHE1239 4.6 77.4 1.0
H18 A:H561306 4.6 85.0 1.0
H14 A:H561306 4.6 85.0 1.0
CD2 A:PHE772 4.7 90.2 1.0
CD2 A:LEU1234 4.7 84.9 1.0
CG A:PHE772 4.8 90.2 1.0
CE2 A:PHE772 4.9 90.2 1.0

Reference:

M.Hu, F.Yang, Y.Huang, X.You, D.Liu, S.Sun, S.F.Sui. Structural Insights Into the Mechanism of Human NPC1L1-Mediated Cholesterol Uptake. Sci Adv V. 7 2021.
ISSN: ESSN 2375-2548
PubMed: 34272236
DOI: 10.1126/SCIADV.ABG3188
Page generated: Sat Aug 21 13:46:45 2021

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