Fluorine in PDB 7enn: The Structure of ALC1 Bound to the Nucleosome

All present enzymatic activity of The Structure of ALC1 Bound to the Nucleosome:
3.6.4.12;

The binding sites of Fluorine atom in the The Structure of ALC1 Bound to the Nucleosome (pdb code 7enn). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the The Structure of ALC1 Bound to the Nucleosome, PDB code: 7enn:
Jump to Fluorine binding site number: 1; 2; 3;

Fluorine binding site 1 out of 3 in the The Structure of ALC1 Bound to the Nucleosome


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of The Structure of ALC1 Bound to the Nucleosome within 5.0Å range: probe atom residue distance (Å) B Occ K:F902 b:133.2 occ:1.00 F1 K:BEF902 0.0 133.2 1.0 BE K:BEF902 1.7 133.2 1.0 NZ K:LYS77 2.4 75.9 1.0 O3B K:ADP901 2.4 138.7 1.0 F3 K:BEF902 2.6 133.2 1.0 F2 K:BEF902 2.8 133.2 1.0 O1B K:ADP901 3.0 138.7 1.0 PB K:ADP901 3.2 138.7 1.0 CE K:LYS77 3.6 75.9 1.0 O2A K:ADP901 3.8 138.7 1.0 CD K:LYS77 3.9 75.9 1.0 CG K:LYS77 4.0 75.9 1.0 O3A K:ADP901 4.2 138.7 1.0 PA K:ADP901 4.3 138.7 1.0 O1A K:ADP901 4.3 138.7 1.0 O2B K:ADP901 4.5 138.7 1.0 N K:GLY74 4.5 78.1 1.0 CB K:LYS77 4.5 75.9 1.0 NH2 K:ARG457 4.6 80.1 1.0 OE2 K:GLU175 4.7 69.3 1.0 CA K:MET73 4.8 78.8 1.0 N K:LYS77 4.8 75.9 1.0

Fluorine binding site 2 out of 3 in the The Structure of ALC1 Bound to the Nucleosome


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of The Structure of ALC1 Bound to the Nucleosome within 5.0Å range: probe atom residue distance (Å) B Occ K:F902 b:133.2 occ:1.00 F2 K:BEF902 0.0 133.2 1.0 BE K:BEF902 1.7 133.2 1.0 O1B K:ADP901 2.2 138.7 1.0 O1A K:ADP901 2.3 138.7 1.0 NH2 K:ARG457 2.4 80.1 1.0 F3 K:BEF902 2.7 133.2 1.0 F1 K:BEF902 2.8 133.2 1.0 PA K:ADP901 3.2 138.7 1.0 PB K:ADP901 3.3 138.7 1.0 CZ K:ARG457 3.3 80.1 1.0 NH1 K:ARG457 3.5 80.1 1.0 O3A K:ADP901 3.6 138.7 1.0 O2A K:ADP901 3.7 138.7 1.0 O3B K:ADP901 3.7 138.7 1.0 NH1 K:ARG454 4.0 76.3 1.0 O K:GLY427 4.0 74.4 1.0 CA K:GLY427 4.4 74.4 1.0 N K:GLY74 4.4 78.1 1.0 NE K:ARG457 4.4 80.1 1.0 C K:GLY427 4.6 74.4 1.0 O5' K:ADP901 4.7 138.7 1.0 O2B K:ADP901 4.7 138.7 1.0 CA K:GLY74 4.8 78.1 1.0 NZ K:LYS77 4.9 75.9 1.0

Fluorine binding site 3 out of 3 in the The Structure of ALC1 Bound to the Nucleosome


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of The Structure of ALC1 Bound to the Nucleosome within 5.0Å range: probe atom residue distance (Å) B Occ K:F902 b:133.2 occ:1.00 F3 K:BEF902 0.0 133.2 1.0 BE K:BEF902 1.7 133.2 1.0 F1 K:BEF902 2.6 133.2 1.0 F2 K:BEF902 2.7 133.2 1.0 O2A K:ADP901 3.1 138.7 1.0 CG2 K:THR78 3.5 76.7 1.0 O1A K:ADP901 3.6 138.7 1.0 PA K:ADP901 3.8 138.7 1.0 O3B K:ADP901 3.9 138.7 1.0 O1B K:ADP901 4.2 138.7 1.0 OD2 K:ASP174 4.4 67.4 1.0 OD1 K:ASP174 4.5 67.4 1.0 PB K:ADP901 4.5 138.7 1.0 O3A K:ADP901 4.7 138.7 1.0 NZ K:LYS77 4.8 75.9 1.0 O K:GLY427 4.9 74.4 1.0 CG K:ASP174 4.9 67.4 1.0 OE2 K:GLU175 4.9 69.3 1.0 CB K:THR78 5.0 76.7 1.0 CA K:GLY427 5.0 74.4 1.0 N K:THR78 5.0 76.7 1.0

L.Wang, K.Chen, Z.Chen. Structural Basis of ALC1/CHD1L Autoinhibition and the Mechanism of Activation By the Nucleosome. Nat Commun V. 12 4057 2021.
ISSN: ESSN 2041-1723
PubMed: 34210977
DOI: 10.1038/S41467-021-24320-4