Fluorine in PDB 7ew7: Cryo-Em Structure of SEW2871-Bound Sphingosine-1-Phosphate Receptor 1 in Complex with Gi Protein

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Cryo-Em Structure of SEW2871-Bound Sphingosine-1-Phosphate Receptor 1 in Complex with Gi Protein (pdb code 7ew7). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 6 binding sites of Fluorine where determined in the Cryo-Em Structure of SEW2871-Bound Sphingosine-1-Phosphate Receptor 1 in Complex with Gi Protein, PDB code: 7ew7:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6;

Fluorine binding site 1 out of 6 in 7ew7

Go back to Fluorine Binding Sites List in 7ew7
Fluorine binding site 1 out of 6 in the Cryo-Em Structure of SEW2871-Bound Sphingosine-1-Phosphate Receptor 1 in Complex with Gi Protein


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Cryo-Em Structure of SEW2871-Bound Sphingosine-1-Phosphate Receptor 1 in Complex with Gi Protein within 5.0Å range:
probe atom residue distance (Å) B Occ
D:F401

b:140.3
occ:1.00
F01 D:JEX401 0.0 140.3 1.0
C02 D:JEX401 1.4 140.3 1.0
F30 D:JEX401 2.2 140.3 1.0
F29 D:JEX401 2.2 140.3 1.0
C03 D:JEX401 2.4 140.3 1.0
CD2 D:LEU276 2.8 147.4 1.0
S04 D:JEX401 3.1 140.3 1.0
C07 D:JEX401 3.7 140.3 1.0
CG D:LEU276 4.1 147.4 1.0
C13 D:JEX401 4.2 140.3 1.0
C08 D:JEX401 4.2 140.3 1.0
CG D:LEU272 4.5 138.2 1.0
CD1 D:LEU276 4.5 147.4 1.0
O D:LEU272 4.5 138.2 1.0
CB D:LEU276 4.5 147.4 1.0
C05 D:JEX401 4.6 140.3 1.0
CA D:PHE273 4.6 137.8 1.0
C D:LEU272 4.6 138.2 1.0
CD2 D:LEU272 4.6 138.2 1.0
C06 D:JEX401 4.7 140.3 1.0
N D:PHE273 4.7 137.8 1.0
CB D:LEU272 4.8 138.2 1.0
CD2 D:PHE210 4.9 120.6 1.0
CG D:PHE210 4.9 120.6 1.0
CE3 D:TRP269 4.9 118.3 1.0

Fluorine binding site 2 out of 6 in 7ew7

Go back to Fluorine Binding Sites List in 7ew7
Fluorine binding site 2 out of 6 in the Cryo-Em Structure of SEW2871-Bound Sphingosine-1-Phosphate Receptor 1 in Complex with Gi Protein


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Cryo-Em Structure of SEW2871-Bound Sphingosine-1-Phosphate Receptor 1 in Complex with Gi Protein within 5.0Å range:
probe atom residue distance (Å) B Occ
D:F401

b:140.3
occ:1.00
F26 D:JEX401 0.0 140.3 1.0
C25 D:JEX401 1.4 140.3 1.0
F27 D:JEX401 2.2 140.3 1.0
F28 D:JEX401 2.2 140.3 1.0
C23 D:JEX401 2.4 140.3 1.0
OE2 D:GLU121 2.7 151.9 1.0
C22 D:JEX401 3.0 140.3 1.0
CD D:GLU121 3.5 151.9 1.0
OE1 D:GLU121 3.5 151.9 1.0
CD2 D:LEU195 3.5 163.4 1.0
C24 D:JEX401 3.5 140.3 1.0
C21 D:JEX401 4.3 140.3 1.0
ND2 D:ASN101 4.4 146.6 1.0
CD1 D:LEU195 4.5 163.4 1.0
CG D:LEU195 4.6 163.4 1.0
C19 D:JEX401 4.7 140.3 1.0
CG D:GLU121 4.9 151.9 1.0

Fluorine binding site 3 out of 6 in 7ew7

Go back to Fluorine Binding Sites List in 7ew7
Fluorine binding site 3 out of 6 in the Cryo-Em Structure of SEW2871-Bound Sphingosine-1-Phosphate Receptor 1 in Complex with Gi Protein


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Cryo-Em Structure of SEW2871-Bound Sphingosine-1-Phosphate Receptor 1 in Complex with Gi Protein within 5.0Å range:
probe atom residue distance (Å) B Occ
D:F401

b:140.3
occ:1.00
F27 D:JEX401 0.0 140.3 1.0
C25 D:JEX401 1.4 140.3 1.0
F26 D:JEX401 2.2 140.3 1.0
F28 D:JEX401 2.2 140.3 1.0
C23 D:JEX401 2.4 140.3 1.0
ND2 D:ASN101 2.7 146.6 1.0
C24 D:JEX401 2.8 140.3 1.0
OE2 D:GLU121 3.0 151.9 1.0
OE1 D:GLU121 3.2 151.9 1.0
CD D:GLU121 3.4 151.9 1.0
C22 D:JEX401 3.7 140.3 1.0
CG D:ASN101 3.7 146.6 1.0
OD1 D:ASN101 3.9 146.6 1.0
C19 D:JEX401 4.1 140.3 1.0
CG D:MET124 4.5 134.7 1.0
CG D:GLU121 4.7 151.9 1.0
C21 D:JEX401 4.8 140.3 1.0
N16 D:JEX401 4.9 140.3 1.0
CD2 D:LEU297 5.0 141.2 1.0
C17 D:JEX401 5.0 140.3 1.0
C20 D:JEX401 5.0 140.3 1.0

Fluorine binding site 4 out of 6 in 7ew7

Go back to Fluorine Binding Sites List in 7ew7
Fluorine binding site 4 out of 6 in the Cryo-Em Structure of SEW2871-Bound Sphingosine-1-Phosphate Receptor 1 in Complex with Gi Protein


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Cryo-Em Structure of SEW2871-Bound Sphingosine-1-Phosphate Receptor 1 in Complex with Gi Protein within 5.0Å range:
probe atom residue distance (Å) B Occ
D:F401

b:140.3
occ:1.00
F28 D:JEX401 0.0 140.3 1.0
C25 D:JEX401 1.4 140.3 1.0
F26 D:JEX401 2.2 140.3 1.0
F27 D:JEX401 2.2 140.3 1.0
C23 D:JEX401 2.4 140.3 1.0
C22 D:JEX401 3.1 140.3 1.0
ND2 D:ASN101 3.3 146.6 1.0
C24 D:JEX401 3.5 140.3 1.0
CD2 D:LEU297 4.0 141.2 1.0
C21 D:JEX401 4.4 140.3 1.0
CG D:ASN101 4.4 146.6 1.0
OE2 D:GLU121 4.4 151.9 1.0
OD1 D:ASN101 4.6 146.6 1.0
C19 D:JEX401 4.6 140.3 1.0

Fluorine binding site 5 out of 6 in 7ew7

Go back to Fluorine Binding Sites List in 7ew7
Fluorine binding site 5 out of 6 in the Cryo-Em Structure of SEW2871-Bound Sphingosine-1-Phosphate Receptor 1 in Complex with Gi Protein


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 5 of Cryo-Em Structure of SEW2871-Bound Sphingosine-1-Phosphate Receptor 1 in Complex with Gi Protein within 5.0Å range:
probe atom residue distance (Å) B Occ
D:F401

b:140.3
occ:1.00
F29 D:JEX401 0.0 140.3 1.0
C02 D:JEX401 1.3 140.3 1.0
F30 D:JEX401 2.2 140.3 1.0
F01 D:JEX401 2.2 140.3 1.0
C03 D:JEX401 2.3 140.3 1.0
C08 D:JEX401 2.7 140.3 1.0
C13 D:JEX401 2.7 140.3 1.0
C07 D:JEX401 2.8 140.3 1.0
C09 D:JEX401 3.4 140.3 1.0
C12 D:JEX401 3.5 140.3 1.0
CD1 D:PHE210 3.5 120.6 1.0
CZ3 D:TRP269 3.6 118.3 1.0
CG D:PHE210 3.7 120.6 1.0
S04 D:JEX401 3.8 140.3 1.0
CE3 D:TRP269 3.8 118.3 1.0
CE1 D:PHE210 3.9 120.6 1.0
C10 D:JEX401 4.1 140.3 1.0
C11 D:JEX401 4.1 140.3 1.0
CB D:PHE210 4.1 120.6 1.0
C06 D:JEX401 4.1 140.3 1.0
CD2 D:PHE210 4.2 120.6 1.0
CZ D:PHE210 4.4 120.6 1.0
CE2 D:PHE210 4.5 120.6 1.0
C05 D:JEX401 4.7 140.3 1.0
CD2 D:LEU276 4.8 147.4 1.0
CH2 D:TRP269 4.8 118.3 1.0

Fluorine binding site 6 out of 6 in 7ew7

Go back to Fluorine Binding Sites List in 7ew7
Fluorine binding site 6 out of 6 in the Cryo-Em Structure of SEW2871-Bound Sphingosine-1-Phosphate Receptor 1 in Complex with Gi Protein


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 6 of Cryo-Em Structure of SEW2871-Bound Sphingosine-1-Phosphate Receptor 1 in Complex with Gi Protein within 5.0Å range:
probe atom residue distance (Å) B Occ
D:F401

b:140.3
occ:1.00
F30 D:JEX401 0.0 140.3 1.0
C02 D:JEX401 1.4 140.3 1.0
F01 D:JEX401 2.2 140.3 1.0
F29 D:JEX401 2.2 140.3 1.0
C03 D:JEX401 2.3 140.3 1.0
C13 D:JEX401 2.7 140.3 1.0
C07 D:JEX401 3.1 140.3 1.0
C08 D:JEX401 3.3 140.3 1.0
CD2 D:LEU276 3.3 147.4 1.0
S04 D:JEX401 3.6 140.3 1.0
C12 D:JEX401 3.7 140.3 1.0
CB D:PHE210 4.2 120.6 1.0
O D:CYS206 4.3 139.7 1.0
C06 D:JEX401 4.3 140.3 1.0
CB D:CYS206 4.4 139.7 1.0
C D:CYS206 4.4 139.7 1.0
CG D:PHE210 4.5 120.6 1.0
CG2 D:THR207 4.5 138.4 1.0
C09 D:JEX401 4.5 140.3 1.0
CA D:THR207 4.5 138.4 1.0
N D:THR207 4.5 138.4 1.0
C05 D:JEX401 4.7 140.3 1.0
CG D:LEU276 4.8 147.4 1.0
C11 D:JEX401 4.8 140.3 1.0
CD1 D:PHE210 4.9 120.6 1.0
CD2 D:PHE210 5.0 120.6 1.0

Reference:

Y.Yuan, G.Jia, C.Wu, W.Wang, L.Cheng, Q.Li, Z.Li, K.Luo, S.Yang, W.Yan, Z.Su, Z.Shao. Structures of Signaling Complexes of Lipid Receptors S1PR1 and S1PR5 Reveal Mechanisms of Activation and Drug Recognition. Cell Res. 2021.
ISSN: ISSN 1001-0602
PubMed: 34526663
DOI: 10.1038/S41422-021-00566-X
Page generated: Fri Nov 5 13:11:38 2021

Last articles

Zn in 8WB0
Zn in 8WAX
Zn in 8WAU
Zn in 8WAZ
Zn in 8WAY
Zn in 8WAV
Zn in 8WAW
Zn in 8WAT
Zn in 8W7M
Zn in 8WD3
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy