Fluorine in PDB 7exd: Lasmiditan-Bound Serotonin 1F (5-HT1F) Receptor-Gi Protein Complex

The binding sites of Fluorine atom in the Lasmiditan-Bound Serotonin 1F (5-HT1F) Receptor-Gi Protein Complex (pdb code 7exd). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Lasmiditan-Bound Serotonin 1F (5-HT1F) Receptor-Gi Protein Complex, PDB code: 7exd:
Jump to Fluorine binding site number: 1; 2; 3;

Fluorine binding site 1 out of 3 in the Lasmiditan-Bound Serotonin 1F (5-HT1F) Receptor-Gi Protein Complex


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Lasmiditan-Bound Serotonin 1F (5-HT1F) Receptor-Gi Protein Complex within 5.0Å range: probe atom residue distance (Å) B Occ R:F501 b:86.3 occ:1.00 F25 R:05X501 0.0 86.3 1.0 C24 R:05X501 1.4 86.3 1.0 C23 R:05X501 2.4 86.3 1.0 C19 R:05X501 2.4 86.3 1.0 N16 R:05X501 2.7 86.3 1.0 C17 R:05X501 2.8 86.3 1.0 C22 R:05X501 3.7 86.3 1.0 C20 R:05X501 3.7 86.3 1.0 OG1 R:THR182 3.7 90.5 1.0 OG R:SER185 3.7 87.9 1.0 O18 R:05X501 4.0 86.3 1.0 C12 R:05X501 4.0 86.3 1.0 C21 R:05X501 4.1 86.3 1.0 CG R:PRO158 4.2 88.4 1.0 CB R:SER185 4.2 87.9 1.0 CB R:PRO158 4.3 88.4 1.0 C13 R:05X501 4.4 86.3 1.0 CD R:PRO158 4.7 88.4 1.0 F26 R:05X501 4.8 86.3 1.0 F27 R:05X501 4.8 86.3 1.0 CB R:THR182 4.8 90.5 1.0 CD1 R:ILE104 4.9 86.3 1.0 CA R:THR182 4.9 90.5 1.0 OG1 R:THR186 4.9 88.3 1.0

Fluorine binding site 2 out of 3 in the Lasmiditan-Bound Serotonin 1F (5-HT1F) Receptor-Gi Protein Complex


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Lasmiditan-Bound Serotonin 1F (5-HT1F) Receptor-Gi Protein Complex within 5.0Å range: probe atom residue distance (Å) B Occ R:F501 b:86.3 occ:1.00 F26 R:05X501 0.0 86.3 1.0 C22 R:05X501 1.4 86.3 1.0 C23 R:05X501 2.4 86.3 1.0 C21 R:05X501 2.4 86.3 1.0 CB R:HIS176 2.6 90.8 1.0 N R:HIS176 3.4 90.8 1.0 ND2 R:ASN317 3.5 89.4 1.0 CG R:HIS176 3.6 90.8 1.0 CA R:HIS176 3.6 90.8 1.0 C24 R:05X501 3.7 86.3 1.0 C20 R:05X501 3.7 86.3 1.0 CG R:ASN317 3.8 89.4 1.0 OG1 R:THR182 4.0 90.5 1.0 CD2 R:HIS176 4.0 90.8 1.0 CB R:ASN317 4.1 89.4 1.0 C19 R:05X501 4.1 86.3 1.0 OD1 R:ASN317 4.4 89.4 1.0 C R:LYS175 4.5 89.4 1.0 O R:ILE174 4.6 89.7 1.0 C R:HIS176 4.6 90.8 1.0 N R:ASP177 4.7 92.4 1.0 CB R:THR182 4.7 90.5 1.0 F25 R:05X501 4.8 86.3 1.0 F27 R:05X501 4.8 86.3 1.0 ND1 R:HIS176 4.9 90.8 1.0 CA R:LYS175 4.9 89.4 1.0 CD1 R:ILE174 5.0 89.7 1.0

Fluorine binding site 3 out of 3 in the Lasmiditan-Bound Serotonin 1F (5-HT1F) Receptor-Gi Protein Complex


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Lasmiditan-Bound Serotonin 1F (5-HT1F) Receptor-Gi Protein Complex within 5.0Å range: probe atom residue distance (Å) B Occ R:F501 b:86.3 occ:1.00 F27 R:05X501 0.0 86.3 1.0 C20 R:05X501 1.4 86.3 1.0 C21 R:05X501 2.4 86.3 1.0 C19 R:05X501 2.4 86.3 1.0 O18 R:05X501 2.7 86.3 1.0 C17 R:05X501 2.8 86.3 1.0 OE2 R:GLU313 3.3 89.2 1.0 CD R:GLU313 3.3 89.2 1.0 C22 R:05X501 3.7 86.3 1.0 C24 R:05X501 3.7 86.3 1.0 CG1 R:ILE174 3.7 89.7 1.0 CG R:GLU313 3.7 89.2 1.0 CD1 R:ILE174 3.8 89.7 1.0 OE1 R:GLU313 3.8 89.2 1.0 C23 R:05X501 4.1 86.3 1.0 N16 R:05X501 4.2 86.3 1.0 O R:ILE174 4.5 89.7 1.0 C3 R:05X501 4.5 86.3 1.0 C4 R:05X501 4.7 86.3 1.0 F26 R:05X501 4.8 86.3 1.0 F25 R:05X501 4.8 86.3 1.0

S.Huang, P.Xu, Y.Tan, C.You, Y.Zhang, Y.Jiang, H.E.Xu. Structural Basis For Recognition of Anti-Migraine Drug Lasmiditan By the Serotonin Receptor 5-Ht 1F -G Protein Complex. Cell Res. 2021.
ISSN: ISSN 1001-0602
PubMed: 34239069
DOI: 10.1038/S41422-021-00527-4