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Atomistry » Fluorine » PDB 7g9p-7gil » 7gfc | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 7g9p-7gil » 7gfc » |
Fluorine in PDB 7gfc: Group Deposition Sars-Cov-2 Main Protease in Complex with Inhibitors From the Covid Moonshot -- Crystal Structure of Sars-Cov-2 Main Protease in Complex with Eri-Ucb-A0B0DBCB-4 (Mpro-X11616)Enzymatic activity of Group Deposition Sars-Cov-2 Main Protease in Complex with Inhibitors From the Covid Moonshot -- Crystal Structure of Sars-Cov-2 Main Protease in Complex with Eri-Ucb-A0B0DBCB-4 (Mpro-X11616)
All present enzymatic activity of Group Deposition Sars-Cov-2 Main Protease in Complex with Inhibitors From the Covid Moonshot -- Crystal Structure of Sars-Cov-2 Main Protease in Complex with Eri-Ucb-A0B0DBCB-4 (Mpro-X11616):
3.4.22.69; Protein crystallography data
The structure of Group Deposition Sars-Cov-2 Main Protease in Complex with Inhibitors From the Covid Moonshot -- Crystal Structure of Sars-Cov-2 Main Protease in Complex with Eri-Ucb-A0B0DBCB-4 (Mpro-X11616), PDB code: 7gfc
was solved by
D.Fearon,
A.Aimon,
J.C.Aschenbrenner,
B.H.Balcomb,
F.K.R.Bertram,
J.Brandao-Neto,
A.Dias,
A.Douangamath,
L.Dunnett,
A.S.Godoy,
T.J.Gorrie-Stone,
L.Koekemoer,
T.Krojer,
R.M.Lithgo,
P.Lukacik,
P.G.Marples,
H.Mikolajek,
E.Nelson,
C.D.Owen,
A.J.Powell,
V.L.Rangel,
R.Skyner,
C.M.Strain-Damerell,
W.Thompson,
C.W.E.Tomlinson,
C.Wild,
M.A.Walsh,
F.Von Delft,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Group Deposition Sars-Cov-2 Main Protease in Complex with Inhibitors From the Covid Moonshot -- Crystal Structure of Sars-Cov-2 Main Protease in Complex with Eri-Ucb-A0B0DBCB-4 (Mpro-X11616)
(pdb code 7gfc). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Group Deposition Sars-Cov-2 Main Protease in Complex with Inhibitors From the Covid Moonshot -- Crystal Structure of Sars-Cov-2 Main Protease in Complex with Eri-Ucb-A0B0DBCB-4 (Mpro-X11616), PDB code: 7gfc: Jump to Fluorine binding site number: 1; 2; 3; Fluorine binding site 1 out of 3 in 7gfcGo back to Fluorine Binding Sites List in 7gfc
Fluorine binding site 1 out
of 3 in the Group Deposition Sars-Cov-2 Main Protease in Complex with Inhibitors From the Covid Moonshot -- Crystal Structure of Sars-Cov-2 Main Protease in Complex with Eri-Ucb-A0B0DBCB-4 (Mpro-X11616)
Mono view Stereo pair view
Fluorine binding site 2 out of 3 in 7gfcGo back to Fluorine Binding Sites List in 7gfc
Fluorine binding site 2 out
of 3 in the Group Deposition Sars-Cov-2 Main Protease in Complex with Inhibitors From the Covid Moonshot -- Crystal Structure of Sars-Cov-2 Main Protease in Complex with Eri-Ucb-A0B0DBCB-4 (Mpro-X11616)
Mono view Stereo pair view
Fluorine binding site 3 out of 3 in 7gfcGo back to Fluorine Binding Sites List in 7gfc
Fluorine binding site 3 out
of 3 in the Group Deposition Sars-Cov-2 Main Protease in Complex with Inhibitors From the Covid Moonshot -- Crystal Structure of Sars-Cov-2 Main Protease in Complex with Eri-Ucb-A0B0DBCB-4 (Mpro-X11616)
Mono view Stereo pair view
Reference:
M.L.Boby,
D.Fearon,
M.Ferla,
M.Filep,
L.Koekemoer,
M.C.Robinson,
The Covid Moonshot Consortium,
J.D.Chodera,
A.A.Lee,
N.London,
A.Von Delft,
F.Von Delft.
Open Science Discovery of Potent Noncovalent Sars-Cov-2 Main Protease Inhibitors Science 2023.
Page generated: Fri Aug 2 07:36:20 2024
ISSN: ESSN 1095-9203 DOI: 10.1126/SCIENCE.ABO7201 |
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