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Fluorine in PDB 7jut: Crystal Structure of KSR2:MEK1 in Complex with Anp-Pnp, and Allosteric Mek Inhibitor SelumetinibEnzymatic activity of Crystal Structure of KSR2:MEK1 in Complex with Anp-Pnp, and Allosteric Mek Inhibitor Selumetinib
All present enzymatic activity of Crystal Structure of KSR2:MEK1 in Complex with Anp-Pnp, and Allosteric Mek Inhibitor Selumetinib:
2.7.11.1; 2.7.12.2; Protein crystallography data
The structure of Crystal Structure of KSR2:MEK1 in Complex with Anp-Pnp, and Allosteric Mek Inhibitor Selumetinib, PDB code: 7jut
was solved by
Z.M.Khan,
A.C.Dar,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 7jut:
The structure of Crystal Structure of KSR2:MEK1 in Complex with Anp-Pnp, and Allosteric Mek Inhibitor Selumetinib also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of KSR2:MEK1 in Complex with Anp-Pnp, and Allosteric Mek Inhibitor Selumetinib
(pdb code 7jut). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Crystal Structure of KSR2:MEK1 in Complex with Anp-Pnp, and Allosteric Mek Inhibitor Selumetinib, PDB code: 7jut: Fluorine binding site 1 out of 1 in 7jutGo back to Fluorine Binding Sites List in 7jut
Fluorine binding site 1 out
of 1 in the Crystal Structure of KSR2:MEK1 in Complex with Anp-Pnp, and Allosteric Mek Inhibitor Selumetinib
Mono view Stereo pair view
Reference:
Z.M.Khan,
A.M.Real,
W.M.Marsiglia,
A.Chow,
M.E.Duffy,
J.R.Yerabolu,
A.P.Scopton,
A.C.Dar.
Structural Basis For the Action of the Drug Trametinib at Ksr-Bound Mek. Nature 2020.
Page generated: Sun Dec 13 13:58:09 2020
ISSN: ESSN 1476-4687 PubMed: 32927473 DOI: 10.1038/S41586-020-2760-4 |
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