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Atomistry » Fluorine » PDB 7l01-7lci » 7l25 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 7l01-7lci » 7l25 » |
Fluorine in PDB 7l25: HPK1 in Complex with Compound 18Enzymatic activity of HPK1 in Complex with Compound 18
All present enzymatic activity of HPK1 in Complex with Compound 18:
2.7.11.1; Protein crystallography data
The structure of HPK1 in Complex with Compound 18, PDB code: 7l25
was solved by
C.A.Lesburg,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the HPK1 in Complex with Compound 18
(pdb code 7l25). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the HPK1 in Complex with Compound 18, PDB code: 7l25: Jump to Fluorine binding site number: 1; 2; Fluorine binding site 1 out of 2 in 7l25Go back to![]() ![]()
Fluorine binding site 1 out
of 2 in the HPK1 in Complex with Compound 18
![]() Mono view ![]() Stereo pair view
Fluorine binding site 2 out of 2 in 7l25Go back to![]() ![]()
Fluorine binding site 2 out
of 2 in the HPK1 in Complex with Compound 18
![]() Mono view ![]() Stereo pair view
Reference:
E.C.Yu,
J.L.Methot,
X.Fradera,
C.A.Lesburg,
B.M.Lacey,
P.Siliphaivanh,
P.Liu,
D.M.Smith,
Z.Xu,
H.Xu,
J.R.Miller,
M.Bittinger,
A.Pasternak.
Identification of Potent Reverse Indazole Inhibitors For HPK1 Acs Med.Chem.Lett. 2021.
Page generated: Tue Jul 15 21:05:40 2025
ISSN: ISSN 1948-5875 DOI: 10.1021/ACSMEDCHEMLETT.0C00672 |
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