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Fluorine in PDB 7l4u: Crystal Structure of Human Monoacylglycerol Lipase in Complex with Compound 1HProtein crystallography data
The structure of Crystal Structure of Human Monoacylglycerol Lipase in Complex with Compound 1H, PDB code: 7l4u
was solved by
L.Qin,
W.Lane,
R.J.Skene,
D.Dougan,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 7l4u:
The structure of Crystal Structure of Human Monoacylglycerol Lipase in Complex with Compound 1H also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Human Monoacylglycerol Lipase in Complex with Compound 1H
(pdb code 7l4u). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Crystal Structure of Human Monoacylglycerol Lipase in Complex with Compound 1H, PDB code: 7l4u: Jump to Fluorine binding site number: 1; 2; Fluorine binding site 1 out of 2 in 7l4uGo back to![]() ![]()
Fluorine binding site 1 out
of 2 in the Crystal Structure of Human Monoacylglycerol Lipase in Complex with Compound 1H
![]() Mono view ![]() Stereo pair view
Fluorine binding site 2 out of 2 in 7l4uGo back to![]() ![]()
Fluorine binding site 2 out
of 2 in the Crystal Structure of Human Monoacylglycerol Lipase in Complex with Compound 1H
![]() Mono view ![]() Stereo pair view
Reference:
S.Ikeda,
H.Sugiyama,
H.Tokuhara,
M.Murakami,
M.Nakamura,
Y.Oguro,
J.Aida,
N.Morishita,
S.Sogabe,
D.R.Dougan,
S.C.Gay,
L.Qin,
N.Arimura,
Y.Takahashi,
M.Sasaki,
Y.Kamada,
K.Aoyama,
K.Kimoto,
M.Kamata.
Design and Synthesis of Novel Spiro Derivatives As Potent and Reversible Monoacylglycerol Lipase (Magl) Inhibitors: Bioisosteric Transformation From 3-Oxo-3,4-Dihydro-2 H -Benzo[ B ][1,4]Oxazin-6-Yl Moiety. J.Med.Chem. 2021.
Page generated: Fri Aug 2 08:45:08 2024
ISSN: ISSN 0022-2623 PubMed: 34328319 DOI: 10.1021/ACS.JMEDCHEM.1C00432 |
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