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Fluorine in PDB 7l4w: Crystal Structure of Human Monoacylglycerol Lipase in Complex with Compound 2DProtein crystallography data
The structure of Crystal Structure of Human Monoacylglycerol Lipase in Complex with Compound 2D, PDB code: 7l4w
was solved by
L.Qin,
W.Lane,
R.J.Skene,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 7l4w:
The structure of Crystal Structure of Human Monoacylglycerol Lipase in Complex with Compound 2D also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Human Monoacylglycerol Lipase in Complex with Compound 2D
(pdb code 7l4w). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Crystal Structure of Human Monoacylglycerol Lipase in Complex with Compound 2D, PDB code: 7l4w: Jump to Fluorine binding site number: 1; 2; Fluorine binding site 1 out of 2 in 7l4wGo back to Fluorine Binding Sites List in 7l4w
Fluorine binding site 1 out
of 2 in the Crystal Structure of Human Monoacylglycerol Lipase in Complex with Compound 2D
Mono view Stereo pair view
Fluorine binding site 2 out of 2 in 7l4wGo back to Fluorine Binding Sites List in 7l4w
Fluorine binding site 2 out
of 2 in the Crystal Structure of Human Monoacylglycerol Lipase in Complex with Compound 2D
Mono view Stereo pair view
Reference:
S.Ikeda,
H.Sugiyama,
H.Tokuhara,
M.Murakami,
M.Nakamura,
Y.Oguro,
J.Aida,
N.Morishita,
S.Sogabe,
D.R.Dougan,
S.C.Gay,
L.Qin,
N.Arimura,
Y.Takahashi,
M.Sasaki,
Y.Kamada,
K.Aoyama,
K.Kimoto,
M.Kamata.
Design and Synthesis of Novel Spiro Derivatives As Potent and Reversible Monoacylglycerol Lipase (Magl) Inhibitors: Bioisosteric Transformation From 3-Oxo-3,4-Dihydro-2 H -Benzo[ B ][1,4]Oxazin-6-Yl Moiety. J.Med.Chem. 2021.
Page generated: Sat Aug 21 13:49:19 2021
ISSN: ISSN 0022-2623 PubMed: 34328319 DOI: 10.1021/ACS.JMEDCHEM.1C00432 |
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