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Fluorine in PDB 7lom: Ornithine Aminotransferase (Oat) Soaked with Its Inactivator - (1S, 3S)-3-Amino-4-(Difluoromethylene)Cyclohexene-1-Carboxylic AcidEnzymatic activity of Ornithine Aminotransferase (Oat) Soaked with Its Inactivator - (1S, 3S)-3-Amino-4-(Difluoromethylene)Cyclohexene-1-Carboxylic Acid
All present enzymatic activity of Ornithine Aminotransferase (Oat) Soaked with Its Inactivator - (1S, 3S)-3-Amino-4-(Difluoromethylene)Cyclohexene-1-Carboxylic Acid:
2.6.1.13; Protein crystallography data
The structure of Ornithine Aminotransferase (Oat) Soaked with Its Inactivator - (1S, 3S)-3-Amino-4-(Difluoromethylene)Cyclohexene-1-Carboxylic Acid, PDB code: 7lom
was solved by
A.Butrin,
W.Zhu,
D.Liu,
R.Silverman,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Ornithine Aminotransferase (Oat) Soaked with Its Inactivator - (1S, 3S)-3-Amino-4-(Difluoromethylene)Cyclohexene-1-Carboxylic Acid
(pdb code 7lom). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Ornithine Aminotransferase (Oat) Soaked with Its Inactivator - (1S, 3S)-3-Amino-4-(Difluoromethylene)Cyclohexene-1-Carboxylic Acid, PDB code: 7lom: Fluorine binding site 1 out of 1 in 7lomGo back to Fluorine Binding Sites List in 7lom
Fluorine binding site 1 out
of 1 in the Ornithine Aminotransferase (Oat) Soaked with Its Inactivator - (1S, 3S)-3-Amino-4-(Difluoromethylene)Cyclohexene-1-Carboxylic Acid
Mono view Stereo pair view
Reference:
W.Zhu,
P.F.Doubleday,
A.Butrin,
P.M.Weerawarna,
R.D.Melani,
D.S.Catlin,
T.A.Dwight,
D.Liu,
N.L.Kelleher,
R.B.Silverman.
Remarkable and Unexpected Mechanism For ( S )-3-Amino-4-(Difluoromethylenyl)Cyclohex-1-Ene-1-Carboxylic Acid As A Selective Inactivator of Human Ornithine Aminotransferase. J.Am.Chem.Soc. V. 143 8193 2021.
Page generated: Fri Sep 24 13:28:16 2021
ISSN: ESSN 1520-5126 PubMed: 34014654 DOI: 10.1021/JACS.1C03572 |
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