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Fluorine in PDB 7ltx: Egfr (T790M/V948R) in Complex with Quinazolinone Allosteric InhibitorEnzymatic activity of Egfr (T790M/V948R) in Complex with Quinazolinone Allosteric Inhibitor
All present enzymatic activity of Egfr (T790M/V948R) in Complex with Quinazolinone Allosteric Inhibitor:
2.7.10.1; Protein crystallography data
The structure of Egfr (T790M/V948R) in Complex with Quinazolinone Allosteric Inhibitor, PDB code: 7ltx
was solved by
T.S.Beyett,
M.J.Eck,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 7ltx:
The structure of Egfr (T790M/V948R) in Complex with Quinazolinone Allosteric Inhibitor also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Egfr (T790M/V948R) in Complex with Quinazolinone Allosteric Inhibitor
(pdb code 7ltx). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 4 binding sites of Fluorine where determined in the Egfr (T790M/V948R) in Complex with Quinazolinone Allosteric Inhibitor, PDB code: 7ltx: Jump to Fluorine binding site number: 1; 2; 3; 4; Fluorine binding site 1 out of 4 in 7ltxGo back to Fluorine Binding Sites List in 7ltx
Fluorine binding site 1 out
of 4 in the Egfr (T790M/V948R) in Complex with Quinazolinone Allosteric Inhibitor
Mono view Stereo pair view
Fluorine binding site 2 out of 4 in 7ltxGo back to Fluorine Binding Sites List in 7ltx
Fluorine binding site 2 out
of 4 in the Egfr (T790M/V948R) in Complex with Quinazolinone Allosteric Inhibitor
Mono view Stereo pair view
Fluorine binding site 3 out of 4 in 7ltxGo back to Fluorine Binding Sites List in 7ltx
Fluorine binding site 3 out
of 4 in the Egfr (T790M/V948R) in Complex with Quinazolinone Allosteric Inhibitor
Mono view Stereo pair view
Fluorine binding site 4 out of 4 in 7ltxGo back to Fluorine Binding Sites List in 7ltx
Fluorine binding site 4 out
of 4 in the Egfr (T790M/V948R) in Complex with Quinazolinone Allosteric Inhibitor
Mono view Stereo pair view
Reference:
T.W.Gero,
D.E.Heppner,
T.S.Beyett,
C.To,
S.C.Azevedo,
J.Jang,
T.Bunnell,
F.Feru,
Z.Li,
B.H.Shin,
K.M.Soroko,
P.C.Gokhale,
N.S.Gray,
P.A.Janne,
M.J.Eck,
D.A.Scott.
Quinazolinones As Allosteric Fourth-Generation Egfr Inhibitors For the Treatment of Nsclc. Bioorg.Med.Chem.Lett. V. 68 28718 2022.
Page generated: Fri Aug 2 09:02:17 2024
ISSN: ESSN 1464-3405 PubMed: 35378251 DOI: 10.1016/J.BMCL.2022.128718 |
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