Atomistry » Fluorine » PDB 7m04-7mbo » 7m5z
Atomistry »
  Fluorine »
    PDB 7m04-7mbo »
      7m5z »

Fluorine in PDB 7m5z: Crystal Structure of the Mertk Kinase Domain in Complex with Inhibitor MIPS15692

Enzymatic activity of Crystal Structure of the Mertk Kinase Domain in Complex with Inhibitor MIPS15692

All present enzymatic activity of Crystal Structure of the Mertk Kinase Domain in Complex with Inhibitor MIPS15692:
2.7.10.1;

Protein crystallography data

The structure of Crystal Structure of the Mertk Kinase Domain in Complex with Inhibitor MIPS15692, PDB code: 7m5z was solved by S.J.Hermans, N.C.Hancock, J.B.Baell, M.W.Parker, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 44.12 / 3.06
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 70.203, 91.272, 100.804, 90, 90, 90
R / Rfree (%) 26.3 / 29.7

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Crystal Structure of the Mertk Kinase Domain in Complex with Inhibitor MIPS15692 (pdb code 7m5z). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Crystal Structure of the Mertk Kinase Domain in Complex with Inhibitor MIPS15692, PDB code: 7m5z:
Jump to Fluorine binding site number: 1; 2;

Fluorine binding site 1 out of 2 in 7m5z

Go back to Fluorine Binding Sites List in 7m5z
Fluorine binding site 1 out of 2 in the Crystal Structure of the Mertk Kinase Domain in Complex with Inhibitor MIPS15692


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Crystal Structure of the Mertk Kinase Domain in Complex with Inhibitor MIPS15692 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F901

b:86.4
occ:1.00
F20 A:YR7901 0.0 86.4 1.0
C19 A:YR7901 1.4 81.8 1.0
C18 A:YR7901 2.3 70.3 1.0
C17 A:YR7901 2.7 74.8 1.0
N16 A:YR7901 3.8 81.5 1.0
C15 A:YR7901 4.2 89.0 1.0
C14 A:YR7901 4.8 85.5 1.0
C21 A:YR7901 4.9 78.0 1.0

Fluorine binding site 2 out of 2 in 7m5z

Go back to Fluorine Binding Sites List in 7m5z
Fluorine binding site 2 out of 2 in the Crystal Structure of the Mertk Kinase Domain in Complex with Inhibitor MIPS15692


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Crystal Structure of the Mertk Kinase Domain in Complex with Inhibitor MIPS15692 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:F901

b:79.2
occ:1.00
F20 B:YR7901 0.0 79.2 1.0
C19 B:YR7901 1.4 72.2 1.0
C18 B:YR7901 2.4 68.4 1.0
C17 B:YR7901 2.9 71.6 1.0
N16 B:YR7901 3.1 70.9 1.0
C15 B:YR7901 3.2 76.3 1.0
C14 B:YR7901 4.0 76.1 1.0
C21 B:YR7901 4.5 66.4 1.0

Reference:

S.W.Wong, L.Vivash, R.Mudududdla, N.Nguyen, S.J.Hermans, D.M.Shackleford, J.Field, L.Xue, A.Aprico, N.C.Hancock, M.Haskali, M.A.Stashko, S.V.Frye, X.Wang, M.D.Binder, U.Ackermann, M.W.Parker, T.J.Kilpatrick, J.B.Baell. Development of [ 18 F]MIPS15692, A Radiotracer with in Vitro Proof-of-Concept For the Imaging of Mer Tyrosine Kinase (Mertk) in Neuroinflammatory Disease. Eur.J.Med.Chem. V. 226 13822 2021.
ISSN: ISSN 0223-5234
PubMed: 34563964
DOI: 10.1016/J.EJMECH.2021.113822
Page generated: Fri Aug 2 09:23:03 2024

Last articles

Zn in 9JPJ
Zn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy