Fluorine in PDB 7m7n: Human Dna Pol Eta with 2'-Fa-Ended Primer and Dampnpp

All present enzymatic activity of Human Dna Pol Eta with 2'-Fa-Ended Primer and Dampnpp:
2.7.7.7;

The structure of Human Dna Pol Eta with 2'-Fa-Ended Primer and Dampnpp, PDB code: 7m7n was solved by M.T.Gregory, Y.Gao, W.Yang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	21.31 / 1.31
Space group	P 61
Cell size a, b, c (Å), α, β, γ (°)	98.444, 98.444, 82.105, 90, 90, 120
R / Rfree (%)	18.4 / 21

The structure of Human Dna Pol Eta with 2'-Fa-Ended Primer and Dampnpp also contains other interesting chemical elements:

Magnesium

(Mg)

2 atoms

The binding sites of Fluorine atom in the Human Dna Pol Eta with 2'-Fa-Ended Primer and Dampnpp (pdb code 7m7n). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Human Dna Pol Eta with 2'-Fa-Ended Primer and Dampnpp, PDB code: 7m7n:

Fluorine binding site 1 out of 1 in the Human Dna Pol Eta with 2'-Fa-Ended Primer and Dampnpp


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Human Dna Pol Eta with 2'-Fa-Ended Primer and Dampnpp within 5.0Å range: probe atom residue distance (Å) B Occ P:F9 b:11.5 occ:1.00 F P:AF29 0.0 11.5 1.0 C2' P:AF29 1.4 9.9 1.0 C1' P:AF29 2.3 9.8 1.0 C3' P:AF29 2.3 9.6 1.0 O3' P:AF29 2.6 9.2 1.0 O P:HOH124 3.0 14.7 1.0 C4' P:AF29 3.0 9.4 1.0 O A:HOH861 3.1 13.4 1.0 O4' P:AF29 3.1 12.2 1.0 OG A:SER113 3.2 9.8 1.0 CB A:SER113 3.3 9.7 1.0 O4' A:DZ4501 3.5 8.3 1.0 N9 P:AF29 3.6 9.5 1.0 CG2 A:ILE114 3.8 9.7 1.0 O5' A:DZ4501 3.8 8.1 1.0 C5' A:DZ4501 3.8 8.3 1.0 N3 P:AF29 4.0 12.5 1.0 N A:ILE114 4.1 8.8 1.0 C4 P:AF29 4.2 10.4 1.0 C4' A:DZ4501 4.2 7.3 1.0 O P:HOH135 4.4 34.0 1.0 C5' P:AF29 4.4 11.5 1.0 OD1 A:ASP115 4.4 8.0 1.0 CA A:SER113 4.5 10.1 1.0 C1' A:DZ4501 4.6 7.9 1.0 MG A:MG503 4.6 7.1 1.0 C8 A:DZ4501 4.6 8.2 1.0 N9 A:DZ4501 4.7 7.8 1.0 CB A:ILE114 4.7 9.3 1.0 OE2 A:GLU116 4.7 10.1 1.0 C8 P:AF29 4.8 13.0 1.0 C A:SER113 4.8 8.1 1.0 N A:ASP115 4.8 8.4 1.0 O2A A:DZ4501 4.9 9.8 1.0 PA A:DZ4501 4.9 8.2 1.0 CA A:ILE114 4.9 8.9 1.0

M.T.Gregory, Y.Gao, Q.Cui, W.Yang. Multiple Deprotonation Paths of the Nucleophile 3'-Oh in the Dna Synthesis Reaction Proc.Natl.Acad.Sci.Usa 2021.
ISSN: ESSN 1091-6490