Fluorine in PDB 7mhs: Structure of P97 (Subunits A to E) with Substrate Engaged

All present enzymatic activity of Structure of P97 (Subunits A to E) with Substrate Engaged:
3.6.4.6;

The structure of Structure of P97 (Subunits A to E) with Substrate Engaged also contains other interesting chemical elements:

Magnesium

(Mg)

8 atoms

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 20; Page 3, Binding sites: 21 - 24;

Binding sites:

The binding sites of Fluorine atom in the Structure of P97 (Subunits A to E) with Substrate Engaged (pdb code 7mhs). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 24 binding sites of Fluorine where determined in the Structure of P97 (Subunits A to E) with Substrate Engaged, PDB code: 7mhs:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Fluorine binding site 1 out of 24 in the Structure of P97 (Subunits A to E) with Substrate Engaged


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Structure of P97 (Subunits A to E) with Substrate Engaged within 5.0Å range: probe atom residue distance (Å) B Occ A:F902 b:48.3 occ:1.00 F1 A:BEF902 0.0 48.3 1.0 BE A:BEF902 1.5 48.3 1.0 MG A:MG903 2.0 48.3 1.0 F3 A:BEF902 2.5 48.3 1.0 F2 A:BEF902 2.6 48.3 1.0 O1B A:ADP901 2.6 48.3 1.0 PB A:ADP901 3.0 48.3 1.0 O3B A:ADP901 3.1 48.3 1.0 O2B A:ADP901 3.1 48.3 1.0 NH2 B:ARG638 4.1 35.3 1.0 OE2 A:GLU578 4.1 47.1 1.0 O3A A:ADP901 4.6 48.3 1.0 OG1 A:THR525 4.6 53.0 1.0 NZ A:LYS524 4.6 48.2 1.0 CE A:LYS524 4.6 48.2 1.0 CB A:ASN624 4.8 47.1 1.0 NH1 B:ARG638 4.8 35.3 1.0 OD1 A:ASP577 4.9 50.5 1.0 CD A:GLU578 4.9 47.1 1.0 CZ B:ARG638 4.9 35.3 1.0

Fluorine binding site 2 out of 24 in the Structure of P97 (Subunits A to E) with Substrate Engaged


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Structure of P97 (Subunits A to E) with Substrate Engaged within 5.0Å range: probe atom residue distance (Å) B Occ A:F902 b:48.3 occ:1.00 F2 A:BEF902 0.0 48.3 1.0 BE A:BEF902 1.5 48.3 1.0 O1B A:ADP901 2.5 48.3 1.0 F1 A:BEF902 2.6 48.3 1.0 F3 A:BEF902 2.6 48.3 1.0 CG A:ASN624 3.1 47.1 1.0 OD1 A:ASN624 3.3 47.1 1.0 CB A:PRO520 3.3 43.8 1.0 CB A:ASN624 3.4 47.1 1.0 CA A:PRO520 3.4 43.8 1.0 ND2 A:ASN624 3.6 47.1 1.0 PB A:ADP901 3.9 48.3 1.0 NZ A:LYS524 4.0 48.2 1.0 O2B A:ADP901 4.1 48.3 1.0 MG A:MG903 4.2 48.3 1.0 N A:GLY521 4.3 45.8 1.0 CA A:ASN624 4.3 47.1 1.0 C A:PRO520 4.4 43.8 1.0 N A:PRO520 4.5 43.8 1.0 CE A:LYS524 4.5 48.2 1.0 CG A:PRO520 4.6 43.8 1.0 O3B A:ADP901 4.6 48.3 1.0 NH1 B:ARG638 4.8 35.3 1.0 NE B:ARG635 4.8 39.7 1.0 O3A A:ADP901 4.9 48.3 1.0 N A:ASN624 4.9 47.1 1.0 CD B:ARG635 5.0 39.7 1.0 CD A:PRO520 5.0 43.8 1.0 CB B:ALA632 5.0 34.5 1.0

Fluorine binding site 3 out of 24 in the Structure of P97 (Subunits A to E) with Substrate Engaged


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Structure of P97 (Subunits A to E) with Substrate Engaged within 5.0Å range: probe atom residue distance (Å) B Occ A:F902 b:48.3 occ:1.00 F3 A:BEF902 0.0 48.3 1.0 BE A:BEF902 1.5 48.3 1.0 O1B A:ADP901 2.4 48.3 1.0 NH1 B:ARG638 2.5 35.3 1.0 F1 A:BEF902 2.5 48.3 1.0 F2 A:BEF902 2.6 48.3 1.0 NH2 B:ARG638 2.9 35.3 1.0 CZ B:ARG638 3.1 35.3 1.0 NE B:ARG635 3.3 39.7 1.0 O3B A:ADP901 3.5 48.3 1.0 PB A:ADP901 3.6 48.3 1.0 NH2 B:ARG635 3.7 39.7 1.0 CZ B:ARG635 3.8 39.7 1.0 CD B:ARG635 4.2 39.7 1.0 MG A:MG903 4.2 48.3 1.0 NE B:ARG638 4.4 35.3 1.0 O2B A:ADP901 4.6 48.3 1.0 O3A A:ADP901 4.6 48.3 1.0 CB A:PRO520 4.7 43.8 1.0 CB B:ALA632 5.0 34.5 1.0 NH1 B:ARG635 5.0 39.7 1.0

Fluorine binding site 4 out of 24 in the Structure of P97 (Subunits A to E) with Substrate Engaged


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Structure of P97 (Subunits A to E) with Substrate Engaged within 5.0Å range: probe atom residue distance (Å) B Occ A:F905 b:69.3 occ:1.00 F1 A:BEF905 0.0 69.3 1.0 BE A:BEF905 1.5 69.3 1.0 MG A:MG906 2.0 69.3 1.0 F3 A:BEF905 2.5 69.3 1.0 F2 A:BEF905 2.6 69.3 1.0 O1B A:ADP904 2.6 69.3 1.0 PB A:ADP904 3.1 69.3 1.0 O2B A:ADP904 3.2 69.3 1.0 O3B A:ADP904 3.3 69.3 1.0 OE2 A:GLU305 3.6 70.5 1.0 NH2 B:ARG362 3.6 45.4 1.0 CD A:LYS251 4.2 73.7 1.0 CG A:LYS251 4.6 73.7 1.0 O3A A:ADP904 4.6 69.3 1.0 OD1 A:ASN348 4.7 66.3 1.0 CZ B:ARG362 4.8 45.4 1.0 NZ A:LYS251 4.8 73.7 1.0 CD A:GLU305 4.8 70.5 1.0 OG1 A:THR252 4.8 78.7 1.0 NH2 B:ARG359 4.9 52.7 1.0 N A:GLY248 4.9 63.9 1.0 NH1 B:ARG362 4.9 45.4 1.0

Fluorine binding site 5 out of 24 in the Structure of P97 (Subunits A to E) with Substrate Engaged


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 5 of Structure of P97 (Subunits A to E) with Substrate Engaged within 5.0Å range: probe atom residue distance (Å) B Occ A:F905 b:69.3 occ:1.00 F2 A:BEF905 0.0 69.3 1.0 BE A:BEF905 1.5 69.3 1.0 O1B A:ADP904 2.5 69.3 1.0 F1 A:BEF905 2.6 69.3 1.0 NZ A:LYS251 2.6 73.7 1.0 F3 A:BEF905 2.6 69.3 1.0 OD1 A:ASN348 3.1 66.3 1.0 CD A:LYS251 3.3 73.7 1.0 CE A:LYS251 3.3 73.7 1.0 CA A:PRO247 3.5 58.3 1.0 N A:GLY248 3.8 63.9 1.0 O A:PRO246 3.8 65.3 1.0 PB A:ADP904 4.0 69.3 1.0 CG A:ASN348 4.0 66.3 1.0 CG A:LYS251 4.1 73.7 1.0 C A:PRO247 4.2 58.3 1.0 N A:PRO247 4.2 58.3 1.0 CA A:ASN348 4.2 66.3 1.0 MG A:MG906 4.2 69.3 1.0 C A:PRO246 4.3 65.3 1.0 CB A:PRO247 4.3 58.3 1.0 CB A:ASN348 4.3 66.3 1.0 O A:GLY245 4.4 68.2 1.0 O2B A:ADP904 4.4 69.3 1.0 O3B A:ADP904 4.6 69.3 1.0 N A:ASN348 4.7 66.3 1.0 O3A A:ADP904 4.9 69.3 1.0

Fluorine binding site 6 out of 24 in the Structure of P97 (Subunits A to E) with Substrate Engaged


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 6 of Structure of P97 (Subunits A to E) with Substrate Engaged within 5.0Å range: probe atom residue distance (Å) B Occ A:F905 b:69.3 occ:1.00 F3 A:BEF905 0.0 69.3 1.0 BE A:BEF905 1.5 69.3 1.0 O1B A:ADP904 2.4 69.3 1.0 F1 A:BEF905 2.5 69.3 1.0 F2 A:BEF905 2.6 69.3 1.0 N A:GLY248 2.8 63.9 1.0 CA A:PRO247 3.2 58.3 1.0 O3B A:ADP904 3.2 69.3 1.0 C A:PRO247 3.4 58.3 1.0 CB A:PRO247 3.4 58.3 1.0 PB A:ADP904 3.5 69.3 1.0 NE B:ARG359 3.7 52.7 1.0 CA A:GLY248 3.8 63.9 1.0 NH2 B:ARG362 3.9 45.4 1.0 NH2 B:ARG359 3.9 52.7 1.0 NH1 B:ARG362 4.0 45.4 1.0 OD1 A:ASN348 4.0 66.3 1.0 CZ B:ARG359 4.1 52.7 1.0 MG A:MG906 4.2 69.3 1.0 O2B A:ADP904 4.4 69.3 1.0 CZ B:ARG362 4.5 45.4 1.0 N A:PRO247 4.5 58.3 1.0 O3A A:ADP904 4.5 69.3 1.0 CD B:ARG359 4.5 52.7 1.0 O A:PRO247 4.6 58.3 1.0 CG B:ARG359 4.8 52.7 1.0 NZ A:LYS251 4.8 73.7 1.0 O A:PRO246 4.9 65.3 1.0 CG A:PRO247 4.9 58.3 1.0 CB B:ALA356 5.0 45.4 1.0 CG A:ASN348 5.0 66.3 1.0

Fluorine binding site 7 out of 24 in the Structure of P97 (Subunits A to E) with Substrate Engaged


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 7 of Structure of P97 (Subunits A to E) with Substrate Engaged within 5.0Å range: probe atom residue distance (Å) B Occ B:F902 b:20.3 occ:1.00 F1 B:BEF902 0.0 20.3 1.0 BE B:BEF902 1.5 20.3 1.0 MG B:MG903 2.0 20.3 1.0 F3 B:BEF902 2.5 20.3 1.0 F2 B:BEF902 2.6 20.3 1.0 O3B B:ADP901 2.6 20.3 1.0 O2B B:ADP901 3.1 20.3 1.0 PB B:ADP901 3.2 20.3 1.0 O1B B:ADP901 3.6 20.3 1.0 NH2 C:ARG638 3.9 20.4 1.0 NZ B:LYS524 4.0 20.4 1.0 CE B:LYS524 4.0 20.4 1.0 OE2 B:GLU578 4.1 23.5 1.0 O3A B:ADP901 4.7 20.3 1.0 OG1 B:THR525 4.8 21.3 1.0 ND2 B:ASN624 4.9 23.7 1.0 CZ C:ARG638 5.0 20.4 1.0

Fluorine binding site 8 out of 24 in the Structure of P97 (Subunits A to E) with Substrate Engaged


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 8 of Structure of P97 (Subunits A to E) with Substrate Engaged within 5.0Å range: probe atom residue distance (Å) B Occ B:F902 b:20.3 occ:1.00 F2 B:BEF902 0.0 20.3 1.0 BE B:BEF902 1.5 20.3 1.0 O3B B:ADP901 2.5 20.3 1.0 F1 B:BEF902 2.6 20.3 1.0 F3 B:BEF902 2.6 20.3 1.0 NZ B:LYS524 2.7 20.4 1.0 CE B:LYS524 2.9 20.4 1.0 CA B:PRO520 3.3 22.5 1.0 CB B:PRO520 3.5 22.5 1.0 ND2 B:ASN624 3.8 23.7 1.0 CB B:ASN624 3.9 23.7 1.0 PB B:ADP901 4.0 20.3 1.0 N B:PRO520 4.1 22.5 1.0 CG B:ASN624 4.2 23.7 1.0 MG B:MG903 4.4 20.3 1.0 CD B:LYS524 4.4 20.4 1.0 C B:PRO520 4.4 22.5 1.0 N B:GLY521 4.4 24.5 1.0 O B:GLY518 4.5 22.5 1.0 O B:PRO519 4.6 24.6 1.0 O1B B:ADP901 4.6 20.3 1.0 O2B B:ADP901 4.6 20.3 1.0 C B:PRO519 4.6 24.6 1.0 CG B:PRO520 4.8 22.5 1.0 CD B:PRO520 4.9 22.5 1.0 O B:THR623 5.0 23.1 1.0 O3A B:ADP901 5.0 20.3 1.0 CA B:ASN624 5.0 23.7 1.0

Fluorine binding site 9 out of 24 in the Structure of P97 (Subunits A to E) with Substrate Engaged


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 9 of Structure of P97 (Subunits A to E) with Substrate Engaged within 5.0Å range: probe atom residue distance (Å) B Occ B:F902 b:20.3 occ:1.00 F3 B:BEF902 0.0 20.3 1.0 BE B:BEF902 1.5 20.3 1.0 O3B B:ADP901 2.4 20.3 1.0 F1 B:BEF902 2.5 20.3 1.0 F2 B:BEF902 2.6 20.3 1.0 O1B B:ADP901 2.8 20.3 1.0 PB B:ADP901 3.2 20.3 1.0 CB B:PRO520 3.3 22.5 1.0 NE C:ARG635 3.4 21.8 1.0 NH1 C:ARG638 3.4 20.4 1.0 NH2 C:ARG638 3.5 20.4 1.0 CA B:PRO520 3.7 22.5 1.0 CZ C:ARG638 3.9 20.4 1.0 NH2 C:ARG635 4.0 21.8 1.0 MG B:MG903 4.0 20.3 1.0 CZ C:ARG635 4.1 21.8 1.0 O2B B:ADP901 4.1 20.3 1.0 N B:GLY521 4.2 24.5 1.0 CD C:ARG635 4.2 21.8 1.0 C B:PRO520 4.2 22.5 1.0 O3A B:ADP901 4.4 20.3 1.0 NZ B:LYS524 4.4 20.4 1.0 CG B:PRO520 4.8 22.5 1.0 ND2 B:ASN624 4.8 23.7 1.0

Fluorine binding site 10 out of 24 in the Structure of P97 (Subunits A to E) with Substrate Engaged


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 10 of Structure of P97 (Subunits A to E) with Substrate Engaged within 5.0Å range: probe atom residue distance (Å) B Occ B:F905 b:24.9 occ:1.00 F1 B:BEF905 0.0 24.9 1.0 BE B:BEF905 1.5 24.9 1.0 MG B:MG906 2.0 24.9 1.0 F3 B:BEF905 2.5 24.9 1.0 F2 B:BEF905 2.5 24.9 1.0 O3B B:ADP904 2.6 24.9 1.0 O2B B:ADP904 3.1 24.9 1.0 PB B:ADP904 3.2 24.9 1.0 O1B B:ADP904 3.4 24.9 1.0 NH2 C:ARG362 3.7 22.4 1.0 OD1 B:ASN348 3.8 26.9 1.0 ND2 B:ASN348 3.9 26.9 1.0 OE2 B:GLU305 4.0 31.4 1.0 CG B:ASN348 4.2 26.9 1.0 CE B:LYS251 4.5 25.2 1.0 N B:GLY248 4.6 22.6 1.0 OG1 B:THR252 4.6 26.4 1.0 O3A B:ADP904 4.7 24.9 1.0 NZ B:LYS251 4.7 25.2 1.0 CZ C:ARG362 4.8 22.4 1.0 NH1 C:ARG359 4.8 23.2 1.0 CA B:PRO247 5.0 21.5 1.0 NH1 C:ARG362 5.0 22.4 1.0

Y.Xu, H.Han, I.Cooney, Y.Guo, N.G.Moran, N.R.Zuniga, J.C.Price, C.P.Hill, P.S.Shen. Active Conformation of the P97-P47 Unfoldase Complex. Nat Commun V. 13 2640 2022.
ISSN: ESSN 2041-1723
PubMed: 35552390
DOI: 10.1038/S41467-022-30318-3