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Atomistry » Fluorine » PDB 7mmi-7n13 » 7mx7 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 7mmi-7n13 » 7mx7 » |
Fluorine in PDB 7mx7: PRMT5:MEP50 Complexed with Inhibitor Pf-06939999Enzymatic activity of PRMT5:MEP50 Complexed with Inhibitor Pf-06939999
All present enzymatic activity of PRMT5:MEP50 Complexed with Inhibitor Pf-06939999:
2.1.1.320; Protein crystallography data
The structure of PRMT5:MEP50 Complexed with Inhibitor Pf-06939999, PDB code: 7mx7
was solved by
M.Mctigue,
Y.L.Deng,
W.Liu,
A.Brooun,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the PRMT5:MEP50 Complexed with Inhibitor Pf-06939999
(pdb code 7mx7). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the PRMT5:MEP50 Complexed with Inhibitor Pf-06939999, PDB code: 7mx7: Jump to Fluorine binding site number: 1; 2; 3; Fluorine binding site 1 out of 3 in 7mx7Go back to![]() ![]()
Fluorine binding site 1 out
of 3 in the PRMT5:MEP50 Complexed with Inhibitor Pf-06939999
![]() Mono view ![]() Stereo pair view
Fluorine binding site 2 out of 3 in 7mx7Go back to![]() ![]()
Fluorine binding site 2 out
of 3 in the PRMT5:MEP50 Complexed with Inhibitor Pf-06939999
![]() Mono view ![]() Stereo pair view
Fluorine binding site 3 out of 3 in 7mx7Go back to![]() ![]()
Fluorine binding site 3 out
of 3 in the PRMT5:MEP50 Complexed with Inhibitor Pf-06939999
![]() Mono view ![]() Stereo pair view
Reference:
K.Jensen-Pergakes,
J.Tatlock,
K.A.Maegley,
I.J.Mcalpine,
M.A.Mctigue,
T.Xie,
C.P.Dillon,
Y.Wang,
S.Yamazaki,
N.Spiegel,
M.Shi,
A.Nemeth,
N.Miller,
E.Hendrickson,
H.Lam,
J.Sherrill,
C.Y.Chung,
E.A.Mcmillan,
S.K.Bryant,
P.Palde,
J.Braganza,
A.Brooun,
Y.L.Deng,
V.Goshtasbi,
S.E.Kephart,
R.A.Kumpf,
W.Liu,
R.L.Patman,
E.Rui,
S.Scales,
M.Tran-Dube,
F.Wang,
M.Wythes,
T.A.Paul.
Sam Competitive PRMT5 Inhibitor Pf-06939999 Demonstrates Antitumor Activity in Splicing Dysregulated Nsclc with Decreased Liability of Drug Resistance. Mol.Cancer Ther. 2021.
Page generated: Tue Jul 15 21:54:40 2025
ISSN: ESSN 1538-8514 PubMed: 34737197 DOI: 10.1158/1535-7163.MCT-21-0620 |
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