Fluorine in PDB 7nic: Cryoem Structure of Disease Related M854K MDA5-Dsrna Filament in Complex with Adp-ALF4(Minor Class)

Enzymatic activity of Cryoem Structure of Disease Related M854K MDA5-Dsrna Filament in Complex with Adp-ALF4(Minor Class)

All present enzymatic activity of Cryoem Structure of Disease Related M854K MDA5-Dsrna Filament in Complex with Adp-ALF4(Minor Class):
3.6.4.13;

Other elements in 7nic:

The structure of Cryoem Structure of Disease Related M854K MDA5-Dsrna Filament in Complex with Adp-ALF4(Minor Class) also contains other interesting chemical elements:

Aluminium (Al) 1 atom
Zinc (Zn) 1 atom

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Cryoem Structure of Disease Related M854K MDA5-Dsrna Filament in Complex with Adp-ALF4(Minor Class) (pdb code 7nic). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 4 binding sites of Fluorine where determined in the Cryoem Structure of Disease Related M854K MDA5-Dsrna Filament in Complex with Adp-ALF4(Minor Class), PDB code: 7nic:
Jump to Fluorine binding site number: 1; 2; 3; 4;

Fluorine binding site 1 out of 4 in 7nic

Go back to Fluorine Binding Sites List in 7nic
Fluorine binding site 1 out of 4 in the Cryoem Structure of Disease Related M854K MDA5-Dsrna Filament in Complex with Adp-ALF4(Minor Class)


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Cryoem Structure of Disease Related M854K MDA5-Dsrna Filament in Complex with Adp-ALF4(Minor Class) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F1102

b:113.6
occ:1.00
 F1 A:ALF1102 0.0 113.6 1.0
AL A:ALF1102 1.8 113.6 1.0
F4 A:ALF1102 2.5 113.6 1.0
F3 A:ALF1102 2.5 113.6 1.0
O3B A:ADP1101 2.8 111.5 1.0
HA2 A:GLY795 3.1 105.5 1.0
H A:GLY795 3.3 105.5 1.0
O2B A:ADP1101 3.4 111.5 1.0
F2 A:ALF1102 3.6 113.6 1.0
PB A:ADP1101 3.6 111.5 1.0
OE2 A:GLU445 3.7 95.1 1.0
CA A:GLY795 3.9 105.5 1.0
N A:GLY795 4.0 105.5 1.0
O3A A:ADP1101 4.4 111.5 1.0
HA3 A:GLY795 4.6 105.5 1.0
HD11 A:LEU369 4.6 97.8 1.0
HD23 A:LEU369 4.7 97.8 1.0
C A:GLY795 4.8 105.5 1.0
OD2 A:ASP444 4.8 90.9 1.0
CD A:GLU445 4.8 95.1 1.0
O A:GLY795 4.8 105.5 1.0
HD2 A:LYS336 4.9 105.8 1.0
O1B A:ADP1101 5.0 111.5 1.0
HH12 A:ARG822 5.0 111.5 1.0
H A:GLY333 5.0 112.8 1.0

Fluorine binding site 2 out of 4 in 7nic

Go back to Fluorine Binding Sites List in 7nic
Fluorine binding site 2 out of 4 in the Cryoem Structure of Disease Related M854K MDA5-Dsrna Filament in Complex with Adp-ALF4(Minor Class)


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Cryoem Structure of Disease Related M854K MDA5-Dsrna Filament in Complex with Adp-ALF4(Minor Class) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F1102

b:113.6
occ:1.00
 F2 A:ALF1102 0.0 113.6 1.0
HZ3 A:LYS336 1.7 105.8 1.0
AL A:ALF1102 1.8 113.6 1.0
O2B A:ADP1101 2.3 111.5 1.0
HA A:THR332 2.4 110.2 1.0
F3 A:ALF1102 2.5 113.6 1.0
F4 A:ALF1102 2.5 113.6 1.0
NZ A:LYS336 2.5 105.8 1.0
HD2 A:LYS336 2.6 105.8 1.0
PB A:ADP1101 2.9 111.5 1.0
HZ1 A:LYS336 2.9 105.8 1.0
HG22 A:THR332 3.0 110.2 1.0
HZ2 A:LYS336 3.1 105.8 1.0
O3B A:ADP1101 3.2 111.5 1.0
CE A:LYS336 3.2 105.8 1.0
O1B A:ADP1101 3.3 111.5 1.0
HE3 A:LYS336 3.3 105.8 1.0
HB3 A:ALA490 3.3 107.7 1.0
CD A:LYS336 3.4 105.8 1.0
CA A:THR332 3.4 110.2 1.0
H A:GLY333 3.5 112.8 1.0
F1 A:ALF1102 3.6 113.6 1.0
CG2 A:THR332 3.8 110.2 1.0
HB A:THR332 3.8 110.2 1.0
HD3 A:LYS336 3.8 105.8 1.0
CB A:THR332 3.9 110.2 1.0
HB2 A:ALA490 4.0 107.7 1.0
HE22 A:GLN818 4.1 113.0 1.0
N A:GLY333 4.1 112.8 1.0
CB A:ALA490 4.1 107.7 1.0
HE2 A:LYS336 4.2 105.8 1.0
N A:THR332 4.2 110.2 1.0
HG23 A:THR332 4.2 110.2 1.0
C A:THR332 4.3 110.2 1.0
O A:PRO331 4.3 104.7 1.0
O3A A:ADP1101 4.4 111.5 1.0
OE1 A:GLN818 4.5 113.0 1.0
HG21 A:THR332 4.5 110.2 1.0
C A:PRO331 4.5 104.7 1.0
HG3 A:LYS336 4.5 105.8 1.0
CG A:LYS336 4.5 105.8 1.0
HB2 A:LYS336 4.7 105.8 1.0
H A:THR332 4.7 110.2 1.0
HB1 A:ALA490 4.8 107.7 1.0
O A:LEU330 4.8 105.7 1.0
NE2 A:GLN818 4.8 113.0 1.0
N A:ALA490 5.0 107.7 1.0
CA A:ALA490 5.0 107.7 1.0
HA A:ALA490 5.0 107.7 1.0

Fluorine binding site 3 out of 4 in 7nic

Go back to Fluorine Binding Sites List in 7nic
Fluorine binding site 3 out of 4 in the Cryoem Structure of Disease Related M854K MDA5-Dsrna Filament in Complex with Adp-ALF4(Minor Class)


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Cryoem Structure of Disease Related M854K MDA5-Dsrna Filament in Complex with Adp-ALF4(Minor Class) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F1102

b:113.6
occ:1.00
 F3 A:ALF1102 0.0 113.6 1.0
AL A:ALF1102 1.8 113.6 1.0
O2B A:ADP1101 2.3 111.5 1.0
F2 A:ALF1102 2.5 113.6 1.0
F1 A:ALF1102 2.5 113.6 1.0
HG22 A:THR332 2.8 110.2 1.0
HB A:THR332 3.0 110.2 1.0
HA A:THR332 3.4 110.2 1.0
CG2 A:THR332 3.5 110.2 1.0
OE1 A:GLN818 3.5 113.0 1.0
H A:GLY333 3.5 112.8 1.0
PB A:ADP1101 3.5 111.5 1.0
CB A:THR332 3.6 110.2 1.0
F4 A:ALF1102 3.6 113.6 1.0
HH21 A:ARG824 3.6 119.7 1.0
HG21 A:THR332 3.6 110.2 1.0
O3B A:ADP1101 3.7 111.5 1.0
CA A:THR332 4.0 110.2 1.0
HZ3 A:LYS336 4.1 105.8 1.0
NH2 A:ARG824 4.2 119.7 1.0
HH22 A:ARG824 4.2 119.7 1.0
N A:GLY333 4.3 112.8 1.0
HG23 A:THR332 4.3 110.2 1.0
HE22 A:GLN818 4.4 113.0 1.0
H A:GLY795 4.4 105.5 1.0
O3A A:ADP1101 4.4 111.5 1.0
CD A:GLN818 4.5 113.0 1.0
HH12 A:ARG822 4.6 111.5 1.0
O1B A:ADP1101 4.6 111.5 1.0
HH11 A:ARG822 4.7 111.5 1.0
C A:THR332 4.7 110.2 1.0
HB3 A:ALA490 4.8 107.7 1.0
HA2 A:GLY795 4.8 105.5 1.0
HD2 A:LYS336 4.9 105.8 1.0
OG1 A:THR332 4.9 110.2 1.0
NE2 A:GLN818 4.9 113.0 1.0
NH1 A:ARG822 5.0 111.5 1.0
NZ A:LYS336 5.0 105.8 1.0
HG1 A:THR332 5.0 110.2 1.0

Fluorine binding site 4 out of 4 in 7nic

Go back to Fluorine Binding Sites List in 7nic
Fluorine binding site 4 out of 4 in the Cryoem Structure of Disease Related M854K MDA5-Dsrna Filament in Complex with Adp-ALF4(Minor Class)


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Cryoem Structure of Disease Related M854K MDA5-Dsrna Filament in Complex with Adp-ALF4(Minor Class) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F1102

b:113.6
occ:1.00
 F4 A:ALF1102 0.0 113.6 1.0
AL A:ALF1102 1.8 113.6 1.0
O3B A:ADP1101 2.1 111.5 1.0
F1 A:ALF1102 2.5 113.6 1.0
F2 A:ALF1102 2.5 113.6 1.0
HD2 A:LYS336 2.6 105.8 1.0
PB A:ADP1101 3.0 111.5 1.0
O2B A:ADP1101 3.4 111.5 1.0
HZ3 A:LYS336 3.5 105.8 1.0
CD A:LYS336 3.5 105.8 1.0
F3 A:ALF1102 3.6 113.6 1.0
HD3 A:LYS336 3.6 105.8 1.0
O1B A:ADP1101 3.7 111.5 1.0
OE2 A:GLU445 3.7 95.1 1.0
HB2 A:LYS336 3.7 105.8 1.0
HZ1 A:LYS336 3.9 105.8 1.0
NZ A:LYS336 4.0 105.8 1.0
OD1 A:ASP444 4.1 90.9 1.0
CE A:LYS336 4.3 105.8 1.0
CB A:LYS336 4.4 105.8 1.0
HB3 A:LYS336 4.4 105.8 1.0
O3A A:ADP1101 4.4 111.5 1.0
OD2 A:ASP444 4.4 90.9 1.0
CG A:LYS336 4.5 105.8 1.0
CG A:ASP444 4.7 90.9 1.0
HE3 A:LYS336 4.7 105.8 1.0
HG3 A:LYS336 4.8 105.8 1.0
HA A:THR332 4.8 110.2 1.0
HZ2 A:LYS336 4.8 105.8 1.0
CD A:GLU445 4.9 95.1 1.0
HA A:THR489 4.9 98.9 1.0
H A:GLY333 5.0 112.8 1.0
HB3 A:ALA490 5.0 107.7 1.0

Reference:

Q.Yu, A.Herrero Del Valle, R.Singh, Y.Modis. MDA5 Autoimmune Disease Variant M854K Prevents Atp-Dependent Structural Discrimination of Viral and Cellular Rna. Nat Commun 2021.
ISSN: ESSN 2041-1723
DOI: 10.1038/S41467-021-27062-5
Page generated: Fri Aug 2 10:05:39 2024

Last articles

Zn in 9JPJ
Zn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy