Atomistry » Fluorine » PDB 7nr5-7o4j » 7o2e
Atomistry »
  Fluorine »
    PDB 7nr5-7o4j »
      7o2e »

Fluorine in PDB 7o2e: Crystal Structure of the Human METTL3-METTL14 Complex Bound to Compound 21 (ADO_AD_089)

Enzymatic activity of Crystal Structure of the Human METTL3-METTL14 Complex Bound to Compound 21 (ADO_AD_089)

All present enzymatic activity of Crystal Structure of the Human METTL3-METTL14 Complex Bound to Compound 21 (ADO_AD_089):
2.1.1.348;

Protein crystallography data

The structure of Crystal Structure of the Human METTL3-METTL14 Complex Bound to Compound 21 (ADO_AD_089), PDB code: 7o2e was solved by R.K.Bedi, A.Dolbois, A.Caflisch, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 44.52 / 2.50
Space group P 32 2 1
Cell size a, b, c (Å), α, β, γ (°) 63.93, 63.93, 224.6, 90, 90, 120
R / Rfree (%) 20.6 / 27.3

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Crystal Structure of the Human METTL3-METTL14 Complex Bound to Compound 21 (ADO_AD_089) (pdb code 7o2e). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Crystal Structure of the Human METTL3-METTL14 Complex Bound to Compound 21 (ADO_AD_089), PDB code: 7o2e:

Fluorine binding site 1 out of 1 in 7o2e

Go back to Fluorine Binding Sites List in 7o2e
Fluorine binding site 1 out of 1 in the Crystal Structure of the Human METTL3-METTL14 Complex Bound to Compound 21 (ADO_AD_089)


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Crystal Structure of the Human METTL3-METTL14 Complex Bound to Compound 21 (ADO_AD_089) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F601

b:71.6
occ:1.00
F34 A:UZH601 0.0 71.6 1.0
C33 A:UZH601 1.4 69.8 1.0
C32 A:UZH601 2.3 67.0 1.0
C08 A:UZH601 2.4 68.3 1.0
C07 A:UZH601 2.9 62.8 1.0
CB A:SER511 3.1 73.1 1.0
C05 A:UZH601 3.2 63.8 1.0
OH A:TYR406 3.5 79.3 1.0
N06 A:UZH601 3.6 67.2 1.0
C11 A:UZH601 3.6 66.9 1.0
CA A:SER511 3.6 76.5 1.0
C09 A:UZH601 3.7 65.7 1.0
CE2 A:TYR406 3.7 76.4 1.0
CZ A:TYR406 3.9 78.5 1.0
C10 A:UZH601 4.2 64.1 1.0
O A:SER511 4.3 76.5 1.0
C A:SER511 4.5 76.9 1.0
C35 A:UZH601 4.5 66.0 1.0
C04 A:UZH601 4.6 63.1 1.0
N A:SER511 4.7 80.8 1.0
N12 A:UZH601 4.8 66.0 1.0
CD2 A:TYR406 4.8 82.4 1.0
C29 A:UZH601 4.9 63.7 1.0

Reference:

R.K.Bedi, A.Dolbois, A.Caflisch. Crystal Structure of the Human METTL3-METTL14 Complex Bound to Compound 21 (ADO_AD_089) J.Med.Chem. 2021.
ISSN: ISSN 0022-2623
DOI: 10.1021/ACS.JMEDCHEM.1C00773
Page generated: Fri Aug 2 10:39:44 2024

Last articles

Zn in 9JYW
Zn in 9IR4
Zn in 9IR3
Zn in 9GMX
Zn in 9GMW
Zn in 9JEJ
Zn in 9ERF
Zn in 9ERE
Zn in 9EGV
Zn in 9EGW
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy