Atomistry » Fluorine » PDB 7pav-7pzx » 7pzu
Atomistry »
  Fluorine »
    PDB 7pav-7pzx »
      7pzu »

Fluorine in PDB 7pzu: Lpxc Inhibitors with Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic with Activity Against Multidrug- Resistant Gram-Negative Bacteria

Enzymatic activity of Lpxc Inhibitors with Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic with Activity Against Multidrug- Resistant Gram-Negative Bacteria

All present enzymatic activity of Lpxc Inhibitors with Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic with Activity Against Multidrug- Resistant Gram-Negative Bacteria:
3.5.1.108;

Protein crystallography data

The structure of Lpxc Inhibitors with Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic with Activity Against Multidrug- Resistant Gram-Negative Bacteria, PDB code: 7pzu was solved by M.D.Ryan, T.D.Pallin, M.B.A.C.Lamers, P.M.Leonard, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 63.00 / 2.15
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 35.9, 67.04, 63, 90, 90.21, 90
R / Rfree (%) 18.9 / 23.3

Other elements in 7pzu:

The structure of Lpxc Inhibitors with Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic with Activity Against Multidrug- Resistant Gram-Negative Bacteria also contains other interesting chemical elements:

Zinc (Zn) 1 atom

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Lpxc Inhibitors with Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic with Activity Against Multidrug- Resistant Gram-Negative Bacteria (pdb code 7pzu). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Lpxc Inhibitors with Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic with Activity Against Multidrug- Resistant Gram-Negative Bacteria, PDB code: 7pzu:
Jump to Fluorine binding site number: 1; 2;

Fluorine binding site 1 out of 2 in 7pzu

Go back to Fluorine Binding Sites List in 7pzu
Fluorine binding site 1 out of 2 in the Lpxc Inhibitors with Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic with Activity Against Multidrug- Resistant Gram-Negative Bacteria


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Lpxc Inhibitors with Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic with Activity Against Multidrug- Resistant Gram-Negative Bacteria within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F502

b:57.5
occ:1.00
 F1 A:99I502 0.0 57.5 1.0
C15 A:99I502 1.3 42.1 1.0
C16 A:99I502 2.4 42.7 1.0
C14 A:99I502 2.5 38.6 1.0
C34 A:99I502 2.9 39.9 1.0
CB A:ALA206 2.9 39.9 1.0
C35 A:99I502 3.4 39.4 1.0
CD1 A:LEU200 3.6 42.0 1.0
CG1 A:ILE197 3.6 50.4 1.0
C11 A:99I502 3.6 41.5 1.0
C13 A:99I502 3.7 38.7 1.0
CA A:ALA206 4.0 40.7 1.0
CA A:ILE197 4.1 49.8 1.0
C12 A:99I502 4.1 38.9 1.0
CB A:ILE197 4.2 49.2 1.0
C36 A:99I502 4.4 38.6 1.0
CG2 A:ILE197 4.4 47.8 1.0
CB A:LEU200 4.4 44.0 1.0
C37 A:99I502 4.5 40.7 1.0
CD1 A:ILE197 4.6 48.1 1.0
CG A:LEU200 4.6 43.1 1.0
C9 A:99I502 4.8 40.9 1.0
CE1 A:HIS19 4.9 40.3 1.0
N A:ILE197 4.9 47.2 1.0
N A:ALA206 4.9 42.9 1.0
O A:ILE197 4.9 47.8 1.0
O A:HOH684 5.0 43.7 1.0

Fluorine binding site 2 out of 2 in 7pzu

Go back to Fluorine Binding Sites List in 7pzu
Fluorine binding site 2 out of 2 in the Lpxc Inhibitors with Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic with Activity Against Multidrug- Resistant Gram-Negative Bacteria


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Lpxc Inhibitors with Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic with Activity Against Multidrug- Resistant Gram-Negative Bacteria within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F502

b:41.3
occ:1.00
 F33 A:99I502 0.0 41.3 1.0
C31 A:99I502 1.4 37.0 1.0
C32 A:99I502 2.4 35.7 1.0
C30 A:99I502 2.4 34.5 1.0
OG1 A:THR190 2.9 34.6 1.0
C28 A:99I502 3.1 33.9 1.0
C26 A:99I502 3.2 32.0 1.0
N29 A:99I502 3.3 34.2 1.0
O27 A:99I502 3.3 29.3 1.0
O A:HOH615 3.4 40.9 1.0
O10 A:99I502 3.5 49.7 1.0
C9 A:99I502 3.5 40.9 1.0
CD2 A:LEU18 3.7 31.2 1.0
N8 A:99I502 3.8 40.4 1.0
N1 A:99I502 3.9 30.8 1.0
CB A:THR190 3.9 32.6 1.0
C7 A:99I502 4.1 37.8 1.0
C11 A:99I502 4.1 41.5 1.0
C12 A:99I502 4.2 38.9 1.0
C3 A:99I502 4.3 36.0 1.0
CG2 A:THR190 4.3 31.6 1.0
ZN A:ZN501 4.4 27.7 1.0
C2 A:99I502 4.7 34.0 1.0
C4 A:99I502 4.9 36.7 1.0
O A:MET62 4.9 39.2 1.0

Reference:

M.D.Ryan, T.D.Pallin, T.Mullins, T.Blench, I.Fraser, J.Dallow, N.Ahmed, C.Ellwood, S.Gaines, J.Flores, Y.Blackwell, C.T.Garcia, G.Spence, A.Reeve, T.Panchal, B.Dominguez-Fernandez, P.M.Leonard, M.B.A.C.Lamers, A.Arduin, C.Fotinou, E.Gancia, D.E.Clark, E.Bush, J.Betts, C.Richards, T.Rea-Davies, A.D.Keefe, Y.Zhang, H.T.Soutter, P.A.Centrella, M.A.Clark, J.W.Cuozzo, C.E.Dumelin, S.Habeshian, A.Hunt, E.A.Sigel, D.M.Troast, B.L.M.Dejonge. Lpxc Inhibitors with Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic with Activity Against Multidrug-Resistant Gram-Negative Bacteria To Be Published.
Page generated: Fri Aug 2 11:13:05 2024

Last articles

Zn in 2YRC
Zn in 2YQP
Zn in 2YR2
Zn in 2YQL
Zn in 2YPT
Zn in 2YPA
Zn in 2YPU
Zn in 2YNW
Zn in 2YNT
Zn in 2YNV
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy