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Fluorine in PDB 7r7k: Structure of Human Anaplastic Lymphoma Kinase Domain in Complex with (4-[6-Amino-5-[(1~{R})-1-[5-Fluoro-2-(Triazol-2-Yl)Phenyl]Ethoxy]-3- Pyridyl]Isoindolin-1-One)Enzymatic activity of Structure of Human Anaplastic Lymphoma Kinase Domain in Complex with (4-[6-Amino-5-[(1~{R})-1-[5-Fluoro-2-(Triazol-2-Yl)Phenyl]Ethoxy]-3- Pyridyl]Isoindolin-1-One)
All present enzymatic activity of Structure of Human Anaplastic Lymphoma Kinase Domain in Complex with (4-[6-Amino-5-[(1~{R})-1-[5-Fluoro-2-(Triazol-2-Yl)Phenyl]Ethoxy]-3- Pyridyl]Isoindolin-1-One):
2.7.10.1; Protein crystallography data
The structure of Structure of Human Anaplastic Lymphoma Kinase Domain in Complex with (4-[6-Amino-5-[(1~{R})-1-[5-Fluoro-2-(Triazol-2-Yl)Phenyl]Ethoxy]-3- Pyridyl]Isoindolin-1-One), PDB code: 7r7k
was solved by
M.Mctigue,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Structure of Human Anaplastic Lymphoma Kinase Domain in Complex with (4-[6-Amino-5-[(1~{R})-1-[5-Fluoro-2-(Triazol-2-Yl)Phenyl]Ethoxy]-3- Pyridyl]Isoindolin-1-One)
(pdb code 7r7k). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Structure of Human Anaplastic Lymphoma Kinase Domain in Complex with (4-[6-Amino-5-[(1~{R})-1-[5-Fluoro-2-(Triazol-2-Yl)Phenyl]Ethoxy]-3- Pyridyl]Isoindolin-1-One), PDB code: 7r7k: Fluorine binding site 1 out of 1 in 7r7kGo back to Fluorine Binding Sites List in 7r7k
Fluorine binding site 1 out
of 1 in the Structure of Human Anaplastic Lymphoma Kinase Domain in Complex with (4-[6-Amino-5-[(1~{R})-1-[5-Fluoro-2-(Triazol-2-Yl)Phenyl]Ethoxy]-3- Pyridyl]Isoindolin-1-One)
Mono view Stereo pair view
Reference:
A.Shiba-Ishii,
T.W.Johnson,
I.Dagogo-Jack,
M.Mino-Kenudson,
T.R.Johnson,
P.Wei,
S.L.Weinrich,
M.A.Mctigue,
M.A.Walcott,
L.Nguyen-Phuong,
K.Dionne,
A.Acker,
L.A.Kiedrowski,
A.Do,
J.L.Peterson,
J.L.Barth,
B.Y.Yeap,
J.F.Gainor,
J.J.Lin,
S.Yoda,
A.N.Hata.
Analysis of Lorlatinib Analogs Reveals A Roadmap For Targeting Diverse Compound Resistance Mutations in Alk-Positive Lung Cancer. Nat Cancer V. 3 710 2022.
Page generated: Wed Apr 5 00:52:58 2023
ISSN: ESSN 2662-1347 PubMed: 35726063 DOI: 10.1038/S43018-022-00399-6 |
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