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Fluorine in PDB 7r9p: Crystal Structure of HPK1 in Complex with Compound 14Enzymatic activity of Crystal Structure of HPK1 in Complex with Compound 14
All present enzymatic activity of Crystal Structure of HPK1 in Complex with Compound 14:
2.7.11.1; Protein crystallography data
The structure of Crystal Structure of HPK1 in Complex with Compound 14, PDB code: 7r9p
was solved by
P.Wu,
I.Lehoux,
W.Wang,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of HPK1 in Complex with Compound 14
(pdb code 7r9p). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Crystal Structure of HPK1 in Complex with Compound 14, PDB code: 7r9p: Jump to Fluorine binding site number: 1; 2; Fluorine binding site 1 out of 2 in 7r9pGo back to Fluorine Binding Sites List in 7r9p
Fluorine binding site 1 out
of 2 in the Crystal Structure of HPK1 in Complex with Compound 14
Mono view Stereo pair view
Fluorine binding site 2 out of 2 in 7r9pGo back to Fluorine Binding Sites List in 7r9p
Fluorine binding site 2 out
of 2 in the Crystal Structure of HPK1 in Complex with Compound 14
Mono view Stereo pair view
Reference:
B.K.Chan,
E.Seward,
M.Lainchbury,
T.F.Brewer,
L.An,
T.Blench,
M.W.Cartwright,
G.K.Y.Chan,
E.F.Choo,
J.Drummond,
R.L.Elliott,
E.Gancia,
L.Gazzard,
B.Hu,
G.E.Jones,
X.Luo,
A.Madin,
S.Malhotra,
J.G.Moffat,
J.Pang,
L.Salphati,
C.J.Sneeringer,
C.E.Stivala,
B.Wei,
W.Wang,
P.Wu,
T.P.Heffron.
Discovery of Spiro-Azaindoline Inhibitors of Hematopoietic Progenitor Kinase 1 (HPK1) Acs Med.Chem.Lett. 2021.
Page generated: Thu Mar 31 03:00:22 2022
ISSN: ISSN 1948-5875 DOI: 10.1021/ACSMEDCHEMLETT.1C00473 |
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