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Fluorine in PDB 7sq2: Reprocessed and Refined Structure of Phospholipase C-Beta and Gq Signaling Complex

Enzymatic activity of Reprocessed and Refined Structure of Phospholipase C-Beta and Gq Signaling Complex

All present enzymatic activity of Reprocessed and Refined Structure of Phospholipase C-Beta and Gq Signaling Complex:
3.1.4.11;

Protein crystallography data

The structure of Reprocessed and Refined Structure of Phospholipase C-Beta and Gq Signaling Complex, PDB code: 7sq2 was solved by S.T.Endo-Streeter, J.Sondek, T.K.Harden, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 40.55 / 2.60
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 202.837, 90.817, 93.135, 90, 101.19, 90
R / Rfree (%) 19.9 / 26.3

Other elements in 7sq2:

The structure of Reprocessed and Refined Structure of Phospholipase C-Beta and Gq Signaling Complex also contains other interesting chemical elements:

Aluminium (Al) 1 atom
Calcium (Ca) 1 atom
Magnesium (Mg) 2 atoms

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Reprocessed and Refined Structure of Phospholipase C-Beta and Gq Signaling Complex (pdb code 7sq2). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 4 binding sites of Fluorine where determined in the Reprocessed and Refined Structure of Phospholipase C-Beta and Gq Signaling Complex, PDB code: 7sq2:
Jump to Fluorine binding site number: 1; 2; 3; 4;

Fluorine binding site 1 out of 4 in 7sq2

Go back to Fluorine Binding Sites List in 7sq2
Fluorine binding site 1 out of 4 in the Reprocessed and Refined Structure of Phospholipase C-Beta and Gq Signaling Complex


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Reprocessed and Refined Structure of Phospholipase C-Beta and Gq Signaling Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F401

b:103.3
occ:1.00
 F1 A:ALF401 0.0 103.3 1.0
AL A:ALF401 1.8 67.5 1.0
O1B A:GDP403 2.0 35.2 1.0
NZ A:LYS52 2.3 77.8 1.0
F3 A:ALF401 2.5 75.6 1.0
F4 A:ALF401 2.6 85.8 1.0
N A:GLY208 3.1 64.6 1.0
MG A:MG402 3.1 59.1 1.0
PB A:GDP403 3.2 65.8 1.0
CE A:LYS52 3.3 73.2 1.0
O3B A:GDP403 3.5 70.8 1.0
F2 A:ALF401 3.6 129.7 1.0
CA A:GLY208 3.7 72.2 1.0
CA A:GLY48 3.8 76.1 1.0
O2B A:GDP403 3.9 44.4 1.0
N A:GLU49 3.9 68.3 1.0
O A:VAL206 4.0 68.2 1.0
C A:GLY207 4.0 68.8 1.0
CA A:GLY207 4.2 73.0 1.0
C A:GLY48 4.4 69.4 1.0
OE1 A:GLN209 4.4 70.9 1.0
O3A A:GDP403 4.5 45.4 1.0
NE2 A:GLN209 4.6 61.3 1.0
N A:GLY48 4.6 81.6 1.0
CD A:LYS52 4.7 75.8 1.0
CB A:THR186 4.8 69.1 1.0
OG1 A:THR186 4.8 65.5 1.0
C A:GLY208 4.8 70.8 1.0
CD A:GLN209 4.8 61.9 1.0
O A:HOH503 4.9 54.8 1.0
O A:THR186 4.9 66.8 1.0
C A:VAL206 4.9 71.8 1.0
N A:GLN209 4.9 69.3 1.0

Fluorine binding site 2 out of 4 in 7sq2

Go back to Fluorine Binding Sites List in 7sq2
Fluorine binding site 2 out of 4 in the Reprocessed and Refined Structure of Phospholipase C-Beta and Gq Signaling Complex


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Reprocessed and Refined Structure of Phospholipase C-Beta and Gq Signaling Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F401

b:129.7
occ:1.00
 F2 A:ALF401 0.0 129.7 1.0
AL A:ALF401 1.8 67.5 1.0
F3 A:ALF401 2.5 75.6 1.0
F4 A:ALF401 2.5 85.8 1.0
NH1 A:ARG183 2.9 54.9 1.0
NH2 A:ARG183 2.9 61.8 1.0
N A:THR186 3.0 67.8 1.0
CA A:PRO185 3.0 73.3 1.0
O1B A:GDP403 3.2 35.2 1.0
CZ A:ARG183 3.3 56.0 1.0
C A:PRO185 3.5 67.9 1.0
F1 A:ALF401 3.6 103.3 1.0
CB A:PRO185 3.6 77.5 1.0
OE1 A:GLN209 3.8 70.9 1.0
NE2 A:GLN209 3.8 61.3 1.0
O A:THR186 3.9 66.8 1.0
CA A:THR186 4.1 64.2 1.0
OG1 A:THR186 4.2 65.5 1.0
CD A:GLN209 4.2 61.9 1.0
N A:PRO185 4.2 67.4 1.0
MG A:MG402 4.3 59.1 1.0
O A:HOH503 4.3 54.8 1.0
CB A:THR186 4.4 69.1 1.0
C A:THR186 4.5 61.6 1.0
NE A:ARG183 4.5 61.1 1.0
O A:VAL184 4.5 68.8 1.0
PB A:GDP403 4.6 65.8 1.0
O A:PRO185 4.7 67.5 1.0
CG A:PRO185 4.7 71.8 1.0
C A:VAL184 4.8 65.2 1.0
O1A A:GDP403 4.9 41.7 1.0

Fluorine binding site 3 out of 4 in 7sq2

Go back to Fluorine Binding Sites List in 7sq2
Fluorine binding site 3 out of 4 in the Reprocessed and Refined Structure of Phospholipase C-Beta and Gq Signaling Complex


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Reprocessed and Refined Structure of Phospholipase C-Beta and Gq Signaling Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F401

b:75.6
occ:1.00
 F3 A:ALF401 0.0 75.6 1.0
AL A:ALF401 1.8 67.5 1.0
O A:THR186 2.4 66.8 1.0
F2 A:ALF401 2.5 129.7 1.0
F1 A:ALF401 2.5 103.3 1.0
CB A:THR186 2.9 69.1 1.0
N A:THR186 3.0 67.8 1.0
MG A:MG402 3.1 59.1 1.0
CA A:THR186 3.1 64.2 1.0
C A:THR186 3.1 61.6 1.0
CA A:GLY207 3.3 73.0 1.0
O1B A:GDP403 3.4 35.2 1.0
OG1 A:THR186 3.4 65.5 1.0
F4 A:ALF401 3.6 85.8 1.0
OE1 A:GLN209 3.7 70.9 1.0
N A:GLY208 3.7 64.6 1.0
O A:VAL206 3.8 68.2 1.0
C A:GLY207 4.0 68.8 1.0
CG2 A:THR186 4.1 70.3 1.0
C A:PRO185 4.2 67.9 1.0
N A:GLY207 4.3 73.5 1.0
N A:THR187 4.4 62.6 1.0
C A:VAL206 4.5 71.8 1.0
CD A:GLN209 4.6 61.9 1.0
NZ A:LYS52 4.6 77.8 1.0
O A:HOH503 4.6 54.8 1.0
CA A:PRO185 4.6 73.3 1.0
PB A:GDP403 4.7 65.8 1.0
NE2 A:GLN209 4.7 61.3 1.0
O2B A:GDP403 4.8 44.4 1.0
CA A:GLY208 4.9 72.2 1.0
ND2 B:ASN260 5.0 79.5 1.0
NH1 A:ARG183 5.0 54.9 1.0

Fluorine binding site 4 out of 4 in 7sq2

Go back to Fluorine Binding Sites List in 7sq2
Fluorine binding site 4 out of 4 in the Reprocessed and Refined Structure of Phospholipase C-Beta and Gq Signaling Complex


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Reprocessed and Refined Structure of Phospholipase C-Beta and Gq Signaling Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F401

b:85.8
occ:1.00
 F4 A:ALF401 0.0 85.8 1.0
AL A:ALF401 1.8 67.5 1.0
O1B A:GDP403 2.0 35.2 1.0
F2 A:ALF401 2.5 129.7 1.0
F1 A:ALF401 2.6 103.3 1.0
N A:GLU49 2.6 68.3 1.0
NH1 A:ARG183 3.2 54.9 1.0
NH2 A:ARG183 3.2 61.8 1.0
PB A:GDP403 3.3 65.8 1.0
CA A:GLU49 3.3 64.7 1.0
NE2 A:GLN209 3.3 61.3 1.0
C A:GLY48 3.3 69.4 1.0
CZ A:ARG183 3.6 56.0 1.0
CA A:GLY48 3.6 76.1 1.0
F3 A:ALF401 3.6 75.6 1.0
O3A A:GDP403 3.8 45.4 1.0
O3B A:GDP403 4.0 70.8 1.0
CB A:GLU49 4.1 74.5 1.0
CD A:GLN209 4.2 61.9 1.0
OE1 A:GLN209 4.3 70.9 1.0
NZ A:LYS52 4.3 77.8 1.0
O2B A:GDP403 4.4 44.4 1.0
O A:GLY48 4.5 68.1 1.0
MG A:MG402 4.5 59.1 1.0
C A:GLU49 4.6 70.1 1.0
N A:SER50 4.8 70.5 1.0
O1A A:GDP403 4.8 41.7 1.0
NE A:ARG183 4.8 61.1 1.0
N A:GLY48 4.9 81.6 1.0
O A:HOH503 4.9 54.8 1.0
O A:HOH531 4.9 61.2 1.0
O A:HOH512 5.0 68.8 1.0
N A:GLY208 5.0 64.6 1.0
CG A:GLU49 5.0 75.0 1.0

Reference:

S.T.Endo-Streeter, J.Sondek, T.K.Harden. Kinetic Scaffolding Mediated By A Phospholipase C-{Beta} and Gq Signaling Complex Science V. 330 974 2010.
ISSN: ISSN 0036-8075
PubMed: 20966218
DOI: 10.1126/SCIENCE.1193438
Page generated: Fri Aug 2 13:03:25 2024

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