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Fluorine in PDB 7sqm: Discovery and Preclinical Pharmacology of INE963, A Potent and Fast- Acting Blood-Stage Antimalarial with A High Barrier to Resistance and Potential For Single-Dose Cure in Uncomplicated Malaria
Enzymatic activity of Discovery and Preclinical Pharmacology of INE963, A Potent and Fast- Acting Blood-Stage Antimalarial with A High Barrier to Resistance and Potential For Single-Dose Cure in Uncomplicated Malaria
All present enzymatic activity of Discovery and Preclinical Pharmacology of INE963, A Potent and Fast- Acting Blood-Stage Antimalarial with A High Barrier to Resistance and Potential For Single-Dose Cure in Uncomplicated Malaria:
2.7.11.1;
2.7.11.1;
Protein crystallography data
The structure of Discovery and Preclinical Pharmacology of INE963, A Potent and Fast- Acting Blood-Stage Antimalarial with A High Barrier to Resistance and Potential For Single-Dose Cure in Uncomplicated Malaria, PDB code: 7sqm
was solved by
W.Shu,
F.Yokokawa,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 57.48 / 1.78 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 73.026, 77.045, 86.308, 90, 90, 90 |
| R / Rfree (%) | 17.3 / 20.5 |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Discovery and Preclinical Pharmacology of INE963, A Potent and Fast- Acting Blood-Stage Antimalarial with A High Barrier to Resistance and Potential For Single-Dose Cure in Uncomplicated Malaria
(pdb code 7sqm). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Discovery and Preclinical Pharmacology of INE963, A Potent and Fast- Acting Blood-Stage Antimalarial with A High Barrier to Resistance and Potential For Single-Dose Cure in Uncomplicated Malaria, PDB code: 7sqm:
Jump to Fluorine binding site number: 1; 2;
In total 2 binding sites of Fluorine where determined in the Discovery and Preclinical Pharmacology of INE963, A Potent and Fast- Acting Blood-Stage Antimalarial with A High Barrier to Resistance and Potential For Single-Dose Cure in Uncomplicated Malaria, PDB code: 7sqm:
Jump to Fluorine binding site number: 1; 2;
Fluorine binding site 1 out of 2 in 7sqm
Go back to
Fluorine Binding Sites List in 7sqm
Fluorine binding site 1 out
of 2 in the Discovery and Preclinical Pharmacology of INE963, A Potent and Fast- Acting Blood-Stage Antimalarial with A High Barrier to Resistance and Potential For Single-Dose Cure in Uncomplicated Malaria
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Discovery and Preclinical Pharmacology of INE963, A Potent and Fast- Acting Blood-Stage Antimalarial with A High Barrier to Resistance and Potential For Single-Dose Cure in Uncomplicated Malaria within 5.0Å range:
|
Fluorine binding site 2 out of 2 in 7sqm
Go back to
Fluorine Binding Sites List in 7sqm
Fluorine binding site 2 out
of 2 in the Discovery and Preclinical Pharmacology of INE963, A Potent and Fast- Acting Blood-Stage Antimalarial with A High Barrier to Resistance and Potential For Single-Dose Cure in Uncomplicated Malaria
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Discovery and Preclinical Pharmacology of INE963, A Potent and Fast- Acting Blood-Stage Antimalarial with A High Barrier to Resistance and Potential For Single-Dose Cure in Uncomplicated Malaria within 5.0Å range:
|
Reference:
W.O.Rogers,
C.Wongsrichanalai.
Failure of Artesunate-Mefloquine Combination Therapy For Uncompli-Cated Plasmodium Falciparum Malaria in Southern Cambodia. Malar. J. V., 10 8 2009.
ISSN: ESSN 1475-2875
Page generated: Wed Jul 16 00:14:52 2025
ISSN: ESSN 1475-2875
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