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Atomistry » Fluorine » PDB 7slr-7t21 » 7suj | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 7slr-7t21 » 7suj » |
Fluorine in PDB 7suj: Structure of CHK1 10-Pt. Mutant Complex with LRRK2 Inhibitor 24Enzymatic activity of Structure of CHK1 10-Pt. Mutant Complex with LRRK2 Inhibitor 24
All present enzymatic activity of Structure of CHK1 10-Pt. Mutant Complex with LRRK2 Inhibitor 24:
2.7.11.1; Protein crystallography data
The structure of Structure of CHK1 10-Pt. Mutant Complex with LRRK2 Inhibitor 24, PDB code: 7suj
was solved by
R.L.Palte,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 7suj:
The structure of Structure of CHK1 10-Pt. Mutant Complex with LRRK2 Inhibitor 24 also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Structure of CHK1 10-Pt. Mutant Complex with LRRK2 Inhibitor 24
(pdb code 7suj). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 4 binding sites of Fluorine where determined in the Structure of CHK1 10-Pt. Mutant Complex with LRRK2 Inhibitor 24, PDB code: 7suj: Jump to Fluorine binding site number: 1; 2; 3; 4; Fluorine binding site 1 out of 4 in 7sujGo back to![]() ![]()
Fluorine binding site 1 out
of 4 in the Structure of CHK1 10-Pt. Mutant Complex with LRRK2 Inhibitor 24
![]() Mono view ![]() Stereo pair view
Fluorine binding site 2 out of 4 in 7sujGo back to![]() ![]()
Fluorine binding site 2 out
of 4 in the Structure of CHK1 10-Pt. Mutant Complex with LRRK2 Inhibitor 24
![]() Mono view ![]() Stereo pair view
Fluorine binding site 3 out of 4 in 7sujGo back to![]() ![]()
Fluorine binding site 3 out
of 4 in the Structure of CHK1 10-Pt. Mutant Complex with LRRK2 Inhibitor 24
![]() Mono view ![]() Stereo pair view
Fluorine binding site 4 out of 4 in 7sujGo back to![]() ![]()
Fluorine binding site 4 out
of 4 in the Structure of CHK1 10-Pt. Mutant Complex with LRRK2 Inhibitor 24
![]() Mono view ![]() Stereo pair view
Reference:
M.H.Keylor,
A.Gulati,
S.D.Kattar,
R.E.Johnson,
R.W.Chau,
K.A.Margrey,
M.J.Ardolino,
C.Zarate,
K.E.Poremba,
V.Simov,
G.J.Morriello,
J.J.Acton,
B.Pio,
X.Yan,
R.L.Palte,
S.E.Mcminn,
L.Nogle,
C.A.Lesburg,
D.Adpressa,
S.Lin,
S.Neelamkavil,
P.Liu,
J.Su,
L.G.Hegde,
J.D.Woodhouse,
R.Faltus,
T.Xiong,
P.J.Ciaccio,
J.Piesvaux,
K.M.Otte,
H.B.Wood,
M.E.Kennedy,
D.J.Bennett,
E.F.Dimauro,
M.J.Fell,
P.H.Fuller.
Structure-Guided Discovery of Aminoquinazolines As Brain-Penetrant and Selective LRRK2 Inhibitors. J.Med.Chem. V. 65 838 2022.
Page generated: Wed Jul 16 00:16:16 2025
ISSN: ISSN 0022-2623 PubMed: 34967623 DOI: 10.1021/ACS.JMEDCHEM.1C01968 |
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