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Fluorine in PDB 7t0a: Cryptococcus Neoformans Protein Farnesyltransferase Co-Crystallized with Fpp and Inhibitor 2F
Enzymatic activity of Cryptococcus Neoformans Protein Farnesyltransferase Co-Crystallized with Fpp and Inhibitor 2F
All present enzymatic activity of Cryptococcus Neoformans Protein Farnesyltransferase Co-Crystallized with Fpp and Inhibitor 2F:
2.5.1.58;
2.5.1.58;
Protein crystallography data
The structure of Cryptococcus Neoformans Protein Farnesyltransferase Co-Crystallized with Fpp and Inhibitor 2F, PDB code: 7t0a
was solved by
Y.Wang,
Y.Shi,
L.S.Beese,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 49.93 / 2.10 |
| Space group | P 43 21 2 |
| Cell size a, b, c (Å), α, β, γ (°) | 141.21, 141.21, 129.822, 90, 90, 90 |
| R / Rfree (%) | 18.7 / 21.3 |
Other elements in 7t0a:
The structure of Cryptococcus Neoformans Protein Farnesyltransferase Co-Crystallized with Fpp and Inhibitor 2F also contains other interesting chemical elements:
| Zinc | (Zn) | 1 atom |
| Bromine | (Br) | 1 atom |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Cryptococcus Neoformans Protein Farnesyltransferase Co-Crystallized with Fpp and Inhibitor 2F
(pdb code 7t0a). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Cryptococcus Neoformans Protein Farnesyltransferase Co-Crystallized with Fpp and Inhibitor 2F, PDB code: 7t0a:
Jump to Fluorine binding site number: 1; 2; 3;
In total 3 binding sites of Fluorine where determined in the Cryptococcus Neoformans Protein Farnesyltransferase Co-Crystallized with Fpp and Inhibitor 2F, PDB code: 7t0a:
Jump to Fluorine binding site number: 1; 2; 3;
Fluorine binding site 1 out of 3 in 7t0a
Go back to
Fluorine Binding Sites List in 7t0a
Fluorine binding site 1 out
of 3 in the Cryptococcus Neoformans Protein Farnesyltransferase Co-Crystallized with Fpp and Inhibitor 2F
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Cryptococcus Neoformans Protein Farnesyltransferase Co-Crystallized with Fpp and Inhibitor 2F within 5.0Å range:
|
Fluorine binding site 2 out of 3 in 7t0a
Go back to
Fluorine Binding Sites List in 7t0a
Fluorine binding site 2 out
of 3 in the Cryptococcus Neoformans Protein Farnesyltransferase Co-Crystallized with Fpp and Inhibitor 2F
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Cryptococcus Neoformans Protein Farnesyltransferase Co-Crystallized with Fpp and Inhibitor 2F within 5.0Å range:
|
Fluorine binding site 3 out of 3 in 7t0a
Go back to
Fluorine Binding Sites List in 7t0a
Fluorine binding site 3 out
of 3 in the Cryptococcus Neoformans Protein Farnesyltransferase Co-Crystallized with Fpp and Inhibitor 2F
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Cryptococcus Neoformans Protein Farnesyltransferase Co-Crystallized with Fpp and Inhibitor 2F within 5.0Å range:
|
Reference:
Y.Wang,
F.Xu,
C.B.Nichols,
Y.Shi,
H.W.Hellinga,
J.A.Alspaugh,
M.D.Distefano,
L.S.Beese.
Structure-Guided Discovery of Potent Antifungals That Prevent Ras Signaling By Inhibiting Protein Farnesyltransferase. J.Med.Chem. V. 65 13753 2022.
ISSN: ISSN 0022-2623
PubMed: 36218371
DOI: 10.1021/ACS.JMEDCHEM.2C00902
Page generated: Wed Jul 16 00:19:11 2025
ISSN: ISSN 0022-2623
PubMed: 36218371
DOI: 10.1021/ACS.JMEDCHEM.2C00902
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