Fluorine in PDB 7vsg: Cryo-Em Structure of A Human ATP11C-CDC50A Flippase Reconstituted in the Nanodisc in Ptdser-Occluded E2-Pi State.

All present enzymatic activity of Cryo-Em Structure of A Human ATP11C-CDC50A Flippase Reconstituted in the Nanodisc in Ptdser-Occluded E2-Pi State.:
7.6.2.1;

The binding sites of Fluorine atom in the Cryo-Em Structure of A Human ATP11C-CDC50A Flippase Reconstituted in the Nanodisc in Ptdser-Occluded E2-Pi State. (pdb code 7vsg). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Cryo-Em Structure of A Human ATP11C-CDC50A Flippase Reconstituted in the Nanodisc in Ptdser-Occluded E2-Pi State., PDB code: 7vsg:
Jump to Fluorine binding site number: 1; 2; 3;

Fluorine binding site 1 out of 3 in the Cryo-Em Structure of A Human ATP11C-CDC50A Flippase Reconstituted in the Nanodisc in Ptdser-Occluded E2-Pi State.


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Cryo-Em Structure of A Human ATP11C-CDC50A Flippase Reconstituted in the Nanodisc in Ptdser-Occluded E2-Pi State. within 5.0Å range: probe atom residue distance (Å) B Occ A:F409 b:49.6 occ:1.00 F1 A:BFD409 0.0 49.6 1.0 BE A:BFD409 1.8 49.6 1.0 F3 A:BFD409 2.6 49.6 1.0 N A:GLY675 2.6 55.3 1.0 NZ A:LYS795 2.9 55.6 1.0 OD1 A:BFD409 3.0 49.6 1.0 F2 A:BFD409 3.0 49.6 1.0 ND2 A:ASN819 3.0 62.0 1.0 CE A:LYS795 3.4 55.6 1.0 CA A:GLY675 3.4 55.3 1.0 O A:ASP179 3.5 74.8 1.0 C A:THR674 3.6 47.1 1.0 CA A:THR674 3.7 47.1 1.0 OG1 A:THR674 3.9 47.1 1.0 OD2 A:ASP820 4.1 58.0 1.0 CG A:ASN819 4.2 62.0 1.0 CG A:BFD409 4.3 49.6 1.0 C A:ASP179 4.3 74.8 1.0 C A:GLY675 4.4 55.3 1.0 OE2 A:GLU181 4.4 72.1 1.0 CB A:THR674 4.4 47.1 1.0 O A:BFD409 4.5 49.6 1.0 OD1 A:ASN819 4.6 62.0 1.0 CD A:LYS795 4.6 55.6 1.0 O A:THR674 4.6 47.1 1.0 N A:ASP676 4.7 65.1 1.0 O A:MET790 4.7 57.2 1.0 OD2 A:BFD409 4.7 49.6 1.0 O A:LEU673 4.9 33.1 1.0 N A:THR674 4.9 47.1 1.0 CA A:GLY180 5.0 73.3 1.0

Fluorine binding site 2 out of 3 in the Cryo-Em Structure of A Human ATP11C-CDC50A Flippase Reconstituted in the Nanodisc in Ptdser-Occluded E2-Pi State.


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Cryo-Em Structure of A Human ATP11C-CDC50A Flippase Reconstituted in the Nanodisc in Ptdser-Occluded E2-Pi State. within 5.0Å range: probe atom residue distance (Å) B Occ A:F409 b:49.6 occ:1.00 F2 A:BFD409 0.0 49.6 1.0 BE A:BFD409 1.8 49.6 1.0 OD1 A:ASN819 2.4 62.0 1.0 F3 A:BFD409 2.6 49.6 1.0 ND2 A:ASN819 2.7 62.0 1.0 OD2 A:ASP820 2.8 58.0 1.0 OD2 A:BFD409 2.9 49.6 1.0 CG A:ASN819 2.9 62.0 1.0 OD1 A:BFD409 3.0 49.6 1.0 F1 A:BFD409 3.0 49.6 1.0 OD1 A:ASP820 3.1 58.0 1.0 CA A:GLY180 3.2 73.3 1.0 CG A:ASP820 3.3 58.0 1.0 CG A:BFD409 3.4 49.6 1.0 O A:ASP179 3.7 74.8 1.0 N A:GLY180 3.9 73.3 1.0 C A:ASP179 4.1 74.8 1.0 C A:GLY180 4.2 73.3 1.0 O A:GLY180 4.3 73.3 1.0 CB A:ASN819 4.4 62.0 1.0 N A:ASP820 4.5 58.0 1.0 CA A:GLY817 4.6 58.1 1.0 CB A:ASP820 4.7 58.0 1.0 OG1 A:THR411 4.8 55.3 1.0 CB A:BFD409 4.8 49.6 1.0 N A:GLY817 4.9 58.1 1.0

Fluorine binding site 3 out of 3 in the Cryo-Em Structure of A Human ATP11C-CDC50A Flippase Reconstituted in the Nanodisc in Ptdser-Occluded E2-Pi State.


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Cryo-Em Structure of A Human ATP11C-CDC50A Flippase Reconstituted in the Nanodisc in Ptdser-Occluded E2-Pi State. within 5.0Å range: probe atom residue distance (Å) B Occ A:F409 b:49.6 occ:1.00 F3 A:BFD409 0.0 49.6 1.0 BE A:BFD409 1.8 49.6 1.0 F2 A:BFD409 2.6 49.6 1.0 F1 A:BFD409 2.6 49.6 1.0 OD1 A:BFD409 2.6 49.6 1.0 OG1 A:THR411 2.8 55.3 1.0 OE2 A:GLU181 3.1 72.1 1.0 CG A:BFD409 3.5 49.6 1.0 OD2 A:BFD409 3.5 49.6 1.0 O A:ASP179 3.5 74.8 1.0 OG1 A:THR674 3.6 47.1 1.0 CG2 A:THR411 3.7 55.3 1.0 CB A:THR411 3.8 55.3 1.0 O A:GLY180 4.0 73.3 1.0 CA A:GLY180 4.0 73.3 1.0 CD A:GLU181 4.0 72.1 1.0 C A:GLY180 4.1 73.3 1.0 N A:GLY675 4.2 55.3 1.0 O A:BFD409 4.3 49.6 1.0 ND2 A:ASN819 4.4 62.0 1.0 N A:THR411 4.5 55.3 1.0 C A:ASP179 4.5 74.8 1.0 OE1 A:GLU181 4.5 72.1 1.0 OD2 A:ASP820 4.7 58.0 1.0 CA A:THR411 4.7 55.3 1.0 N A:GLY180 4.7 73.3 1.0 N A:GLY412 4.8 48.5 1.0 CB A:THR674 4.8 47.1 1.0 CB A:BFD409 4.8 49.6 1.0 C A:BFD409 4.8 49.6 1.0 OD1 A:ASN819 4.9 62.0 1.0 CA A:THR674 4.9 47.1 1.0 CA A:GLY675 4.9 55.3 1.0 CG A:GLU181 5.0 72.1 1.0

H.Nakanishi, K.Hayashida, T.Nishizawa, A.Oshima, K.Abe. Cryo-Em of the ATP11C Flippase Reconstituted in Nanodiscs Shows A Distended Phospholipid Bilayer Inner Membrane Around Transmembrane Helix 2. J.Biol.Chem. 01498 2021.
ISSN: ESSN 1083-351X
PubMed: 34922944
DOI: 10.1016/J.JBC.2021.101498