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Fluorine in PDB 7wdb: Human TRPC5 Channel in Complex with Riluzole

Other elements in 7wdb:

The structure of Human TRPC5 Channel in Complex with Riluzole also contains other interesting chemical elements:

Calcium (Ca) 4 atoms
Zinc (Zn) 4 atoms

Fluorine Binding Sites:

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 12;

Binding sites:

The binding sites of Fluorine atom in the Human TRPC5 Channel in Complex with Riluzole (pdb code 7wdb). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 12 binding sites of Fluorine where determined in the Human TRPC5 Channel in Complex with Riluzole, PDB code: 7wdb:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Fluorine binding site 1 out of 12 in 7wdb

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Fluorine binding site 1 out of 12 in the Human TRPC5 Channel in Complex with Riluzole


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Human TRPC5 Channel in Complex with Riluzole within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F905

b:72.0
occ:1.00
 F1 A:657905 0.0 72.0 1.0
C7 A:657905 1.4 76.0 1.0
F2 A:657905 2.2 70.0 1.0
F3 A:657905 2.2 91.8 1.0
O1 A:657905 2.3 73.7 1.0
CD1 A:LEU496 3.0 53.8 1.0
CG A:LEU496 3.1 49.2 1.0
CD2 A:LEU493 3.2 49.7 1.0
C6 A:657905 3.6 73.0 1.0
CD2 A:LEU496 3.7 52.6 1.0
CD2 A:TYR374 3.8 44.7 1.0
CG A:TYR374 4.1 44.2 1.0
CB A:TYR374 4.2 43.0 1.0
C5 A:657905 4.3 70.9 1.0
CE2 A:TYR374 4.4 45.0 1.0
CB A:LEU496 4.4 46.6 1.0
CA A:LEU493 4.5 42.2 1.0
CG A:LEU493 4.6 45.4 1.0
C1 A:657905 4.6 77.4 1.0
O A:ARG492 4.8 52.0 1.0

Fluorine binding site 2 out of 12 in 7wdb

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Fluorine binding site 2 out of 12 in the Human TRPC5 Channel in Complex with Riluzole


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Human TRPC5 Channel in Complex with Riluzole within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F905

b:70.0
occ:1.00
 F2 A:657905 0.0 70.0 1.0
C7 A:657905 1.4 76.0 1.0
F1 A:657905 2.2 72.0 1.0
F3 A:657905 2.2 91.8 1.0
O1 A:657905 2.4 73.7 1.0
C6 A:657905 2.8 73.0 1.0
C5 A:657905 2.9 70.9 1.0
CE2 A:TYR374 3.2 45.0 1.0
CD2 A:TYR374 3.3 44.7 1.0
O A:ARG492 3.5 52.0 1.0
CG A:ARG492 3.5 53.8 1.0
CD2 A:LEU493 3.7 49.7 1.0
CZ A:TYR374 3.7 50.8 1.0
C A:ARG492 3.8 45.2 1.0
CG A:TYR374 3.8 44.2 1.0
CB A:ARG492 4.0 45.8 1.0
N A:LEU493 4.1 44.0 1.0
C1 A:657905 4.1 77.4 1.0
CA A:LEU493 4.1 42.2 1.0
C4 A:657905 4.2 81.7 1.0
CE1 A:TYR374 4.2 55.1 1.0
CD1 A:TYR374 4.2 49.5 1.0
OH A:TYR374 4.4 56.4 1.0
NH1 A:ARG492 4.4 62.3 1.0
OG A:SER495 4.4 57.3 1.0
CA A:ARG492 4.6 40.9 1.0
CB A:TYR374 4.7 43.0 1.0
CG A:LEU493 4.7 45.4 1.0
CD A:ARG492 4.7 61.7 1.0
CG A:LEU496 4.7 49.2 1.0
CZ A:ARG492 5.0 66.4 1.0

Fluorine binding site 3 out of 12 in 7wdb

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Fluorine binding site 3 out of 12 in the Human TRPC5 Channel in Complex with Riluzole


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Human TRPC5 Channel in Complex with Riluzole within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F905

b:91.8
occ:1.00
 F3 A:657905 0.0 91.8 1.0
C7 A:657905 1.4 76.0 1.0
F1 A:657905 2.2 72.0 1.0
F2 A:657905 2.2 70.0 1.0
O1 A:657905 2.3 73.7 1.0
C6 A:657905 2.8 73.0 1.0
CD2 A:LEU496 3.2 52.6 1.0
OG A:SER495 3.3 57.3 1.0
CG A:LEU496 3.4 49.2 1.0
C1 A:657905 3.4 77.4 1.0
NH1 A:ARG492 3.8 62.3 1.0
C5 A:657905 3.8 70.9 1.0
O A:ARG492 3.9 52.0 1.0
CD1 A:LEU496 4.1 53.8 1.0
CB A:SER495 4.6 53.4 1.0
N A:LEU496 4.6 46.0 1.0
CB A:LEU496 4.6 46.6 1.0
C2 A:657905 4.6 82.1 1.0
CZ A:ARG492 4.7 66.4 1.0
CG A:ARG492 4.7 53.8 1.0
C A:ARG492 4.8 45.2 1.0
CD2 A:LEU493 4.9 49.7 1.0
CA A:LEU493 4.9 42.2 1.0
C4 A:657905 5.0 81.7 1.0
C A:SER495 5.0 48.5 1.0
CA A:LEU496 5.0 42.1 1.0

Fluorine binding site 4 out of 12 in 7wdb

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Fluorine binding site 4 out of 12 in the Human TRPC5 Channel in Complex with Riluzole


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Human TRPC5 Channel in Complex with Riluzole within 5.0Å range:
probe atom residue distance (Å) B Occ
B:F905

b:72.0
occ:1.00
 F1 B:657905 0.0 72.0 1.0
C7 B:657905 1.4 76.0 1.0
F2 B:657905 2.2 70.0 1.0
F3 B:657905 2.2 91.8 1.0
O1 B:657905 2.3 73.7 1.0
CD1 B:LEU496 3.0 53.8 1.0
CG B:LEU496 3.1 49.2 1.0
CD2 B:LEU493 3.2 49.7 1.0
C6 B:657905 3.6 73.0 1.0
CD2 B:LEU496 3.7 52.6 1.0
CD2 B:TYR374 3.8 44.7 1.0
CG B:TYR374 4.1 44.2 1.0
CB B:TYR374 4.2 43.0 1.0
C5 B:657905 4.3 70.9 1.0
CE2 B:TYR374 4.4 45.0 1.0
CB B:LEU496 4.4 46.6 1.0
CA B:LEU493 4.5 42.2 1.0
CG B:LEU493 4.6 45.4 1.0
C1 B:657905 4.6 77.4 1.0
O B:ARG492 4.8 52.0 1.0

Fluorine binding site 5 out of 12 in 7wdb

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Fluorine binding site 5 out of 12 in the Human TRPC5 Channel in Complex with Riluzole


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 5 of Human TRPC5 Channel in Complex with Riluzole within 5.0Å range:
probe atom residue distance (Å) B Occ
B:F905

b:70.0
occ:1.00
 F2 B:657905 0.0 70.0 1.0
C7 B:657905 1.4 76.0 1.0
F1 B:657905 2.2 72.0 1.0
F3 B:657905 2.2 91.8 1.0
O1 B:657905 2.4 73.7 1.0
C6 B:657905 2.8 73.0 1.0
C5 B:657905 2.9 70.9 1.0
CE2 B:TYR374 3.2 45.0 1.0
CD2 B:TYR374 3.3 44.7 1.0
O B:ARG492 3.5 52.0 1.0
CG B:ARG492 3.5 53.8 1.0
CD2 B:LEU493 3.7 49.7 1.0
CZ B:TYR374 3.7 50.8 1.0
C B:ARG492 3.8 45.2 1.0
CG B:TYR374 3.8 44.2 1.0
CB B:ARG492 4.0 45.8 1.0
N B:LEU493 4.1 44.0 1.0
C1 B:657905 4.1 77.4 1.0
CA B:LEU493 4.1 42.2 1.0
C4 B:657905 4.2 81.7 1.0
CE1 B:TYR374 4.2 55.1 1.0
CD1 B:TYR374 4.2 49.5 1.0
OH B:TYR374 4.4 56.4 1.0
NH1 B:ARG492 4.4 62.3 1.0
OG B:SER495 4.4 57.3 1.0
CA B:ARG492 4.6 40.9 1.0
CB B:TYR374 4.7 43.0 1.0
CG B:LEU493 4.7 45.4 1.0
CD B:ARG492 4.7 61.7 1.0
CG B:LEU496 4.7 49.2 1.0
CZ B:ARG492 5.0 66.4 1.0

Fluorine binding site 6 out of 12 in 7wdb

Go back to Fluorine Binding Sites List in 7wdb
Fluorine binding site 6 out of 12 in the Human TRPC5 Channel in Complex with Riluzole


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 6 of Human TRPC5 Channel in Complex with Riluzole within 5.0Å range:
probe atom residue distance (Å) B Occ
B:F905

b:91.8
occ:1.00
 F3 B:657905 0.0 91.8 1.0
C7 B:657905 1.4 76.0 1.0
F1 B:657905 2.2 72.0 1.0
F2 B:657905 2.2 70.0 1.0
O1 B:657905 2.3 73.7 1.0
C6 B:657905 2.8 73.0 1.0
CD2 B:LEU496 3.2 52.6 1.0
OG B:SER495 3.3 57.3 1.0
CG B:LEU496 3.4 49.2 1.0
C1 B:657905 3.4 77.4 1.0
NH1 B:ARG492 3.8 62.3 1.0
C5 B:657905 3.8 70.9 1.0
O B:ARG492 3.9 52.0 1.0
CD1 B:LEU496 4.1 53.8 1.0
CB B:SER495 4.6 53.4 1.0
N B:LEU496 4.6 46.0 1.0
CB B:LEU496 4.6 46.6 1.0
C2 B:657905 4.6 82.1 1.0
CZ B:ARG492 4.7 66.4 1.0
CG B:ARG492 4.7 53.8 1.0
C B:ARG492 4.8 45.2 1.0
CD2 B:LEU493 4.9 49.7 1.0
CA B:LEU493 4.9 42.2 1.0
C4 B:657905 5.0 81.7 1.0
C B:SER495 5.0 48.5 1.0
CA B:LEU496 5.0 42.1 1.0

Fluorine binding site 7 out of 12 in 7wdb

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Fluorine binding site 7 out of 12 in the Human TRPC5 Channel in Complex with Riluzole


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 7 of Human TRPC5 Channel in Complex with Riluzole within 5.0Å range:
probe atom residue distance (Å) B Occ
C:F905

b:72.0
occ:1.00
 F1 C:657905 0.0 72.0 1.0
C7 C:657905 1.4 76.0 1.0
F2 C:657905 2.2 70.0 1.0
F3 C:657905 2.2 91.8 1.0
O1 C:657905 2.3 73.7 1.0
CD1 C:LEU496 3.0 53.8 1.0
CG C:LEU496 3.1 49.2 1.0
CD2 C:LEU493 3.2 49.7 1.0
C6 C:657905 3.6 73.0 1.0
CD2 C:LEU496 3.7 52.6 1.0
CD2 C:TYR374 3.8 44.7 1.0
CG C:TYR374 4.1 44.2 1.0
CB C:TYR374 4.2 43.0 1.0
C5 C:657905 4.3 70.9 1.0
CE2 C:TYR374 4.4 45.0 1.0
CB C:LEU496 4.4 46.6 1.0
CA C:LEU493 4.5 42.2 1.0
CG C:LEU493 4.6 45.4 1.0
C1 C:657905 4.6 77.4 1.0
O C:ARG492 4.8 52.0 1.0

Fluorine binding site 8 out of 12 in 7wdb

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Fluorine binding site 8 out of 12 in the Human TRPC5 Channel in Complex with Riluzole


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 8 of Human TRPC5 Channel in Complex with Riluzole within 5.0Å range:
probe atom residue distance (Å) B Occ
C:F905

b:70.0
occ:1.00
 F2 C:657905 0.0 70.0 1.0
C7 C:657905 1.4 76.0 1.0
F1 C:657905 2.2 72.0 1.0
F3 C:657905 2.2 91.8 1.0
O1 C:657905 2.4 73.7 1.0
C6 C:657905 2.8 73.0 1.0
C5 C:657905 2.9 70.9 1.0
CE2 C:TYR374 3.2 45.0 1.0
CD2 C:TYR374 3.3 44.7 1.0
O C:ARG492 3.5 52.0 1.0
CG C:ARG492 3.5 53.8 1.0
CD2 C:LEU493 3.7 49.7 1.0
CZ C:TYR374 3.7 50.8 1.0
C C:ARG492 3.8 45.2 1.0
CG C:TYR374 3.8 44.2 1.0
CB C:ARG492 4.0 45.8 1.0
N C:LEU493 4.1 44.0 1.0
C1 C:657905 4.1 77.4 1.0
CA C:LEU493 4.1 42.2 1.0
C4 C:657905 4.2 81.7 1.0
CE1 C:TYR374 4.2 55.1 1.0
CD1 C:TYR374 4.2 49.5 1.0
OH C:TYR374 4.4 56.4 1.0
NH1 C:ARG492 4.4 62.3 1.0
OG C:SER495 4.4 57.3 1.0
CA C:ARG492 4.6 40.9 1.0
CB C:TYR374 4.7 43.0 1.0
CG C:LEU493 4.7 45.4 1.0
CD C:ARG492 4.7 61.7 1.0
CG C:LEU496 4.7 49.2 1.0
CZ C:ARG492 5.0 66.4 1.0

Fluorine binding site 9 out of 12 in 7wdb

Go back to Fluorine Binding Sites List in 7wdb
Fluorine binding site 9 out of 12 in the Human TRPC5 Channel in Complex with Riluzole


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 9 of Human TRPC5 Channel in Complex with Riluzole within 5.0Å range:
probe atom residue distance (Å) B Occ
C:F905

b:91.8
occ:1.00
 F3 C:657905 0.0 91.8 1.0
C7 C:657905 1.4 76.0 1.0
F1 C:657905 2.2 72.0 1.0
F2 C:657905 2.2 70.0 1.0
O1 C:657905 2.3 73.7 1.0
C6 C:657905 2.8 73.0 1.0
CD2 C:LEU496 3.2 52.6 1.0
OG C:SER495 3.3 57.3 1.0
CG C:LEU496 3.4 49.2 1.0
C1 C:657905 3.4 77.4 1.0
NH1 C:ARG492 3.8 62.3 1.0
C5 C:657905 3.8 70.9 1.0
O C:ARG492 3.9 52.0 1.0
CD1 C:LEU496 4.1 53.8 1.0
CB C:SER495 4.6 53.4 1.0
N C:LEU496 4.6 46.0 1.0
CB C:LEU496 4.6 46.6 1.0
C2 C:657905 4.6 82.1 1.0
CZ C:ARG492 4.7 66.4 1.0
CG C:ARG492 4.7 53.8 1.0
C C:ARG492 4.8 45.2 1.0
CD2 C:LEU493 4.9 49.7 1.0
CA C:LEU493 4.9 42.2 1.0
C4 C:657905 5.0 81.7 1.0
C C:SER495 5.0 48.5 1.0
CA C:LEU496 5.0 42.1 1.0

Fluorine binding site 10 out of 12 in 7wdb

Go back to Fluorine Binding Sites List in 7wdb
Fluorine binding site 10 out of 12 in the Human TRPC5 Channel in Complex with Riluzole


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 10 of Human TRPC5 Channel in Complex with Riluzole within 5.0Å range:
probe atom residue distance (Å) B Occ
D:F905

b:72.0
occ:1.00
 F1 D:657905 0.0 72.0 1.0
C7 D:657905 1.4 76.0 1.0
F2 D:657905 2.2 70.0 1.0
F3 D:657905 2.2 91.8 1.0
O1 D:657905 2.3 73.7 1.0
CD1 D:LEU496 3.0 53.8 1.0
CG D:LEU496 3.1 49.2 1.0
CD2 D:LEU493 3.2 49.7 1.0
C6 D:657905 3.6 73.0 1.0
CD2 D:LEU496 3.7 52.6 1.0
CD2 D:TYR374 3.8 44.7 1.0
CG D:TYR374 4.1 44.2 1.0
CB D:TYR374 4.2 43.0 1.0
C5 D:657905 4.3 70.9 1.0
CE2 D:TYR374 4.4 45.0 1.0
CB D:LEU496 4.4 46.6 1.0
CA D:LEU493 4.5 42.2 1.0
CG D:LEU493 4.6 45.4 1.0
C1 D:657905 4.6 77.4 1.0
O D:ARG492 4.8 52.0 1.0

Reference:

Y.Yang, M.Wei, L.Chen. Structural Identification of Riluzole-Binding Site on Human TRPC5. Cell Discov V. 8 67 2022.
ISSN: ESSN 2056-5968
PubMed: 35821012
DOI: 10.1038/S41421-022-00410-5
Page generated: Fri Aug 2 14:49:23 2024

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