Fluorine in PDB 7zl3: Signal Peptide Mimicry Primes SEC61 For Client-Selective Inhibition
Other elements in 7zl3:
The structure of Signal Peptide Mimicry Primes SEC61 For Client-Selective Inhibition also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Signal Peptide Mimicry Primes SEC61 For Client-Selective Inhibition
(pdb code 7zl3). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 6 binding sites of Fluorine where determined in the
Signal Peptide Mimicry Primes SEC61 For Client-Selective Inhibition, PDB code: 7zl3:
Jump to Fluorine binding site number:
1;
2;
3;
4;
5;
6;
Fluorine binding site 1 out
of 6 in 7zl3
Go back to
Fluorine Binding Sites List in 7zl3
Fluorine binding site 1 out
of 6 in the Signal Peptide Mimicry Primes SEC61 For Client-Selective Inhibition
Mono view
Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Signal Peptide Mimicry Primes SEC61 For Client-Selective Inhibition within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
E:F2
b:182.4
occ:1.00
|
FAC
|
E:3EG2
|
0.0
|
182.4
|
1.0
|
CG
|
E:3EG2
|
1.4
|
182.4
|
1.0
|
FAE
|
E:3EG2
|
2.3
|
182.4
|
1.0
|
FAD
|
E:3EG2
|
2.4
|
182.4
|
1.0
|
CB
|
E:3EG2
|
2.5
|
182.4
|
1.0
|
O3
|
E:JMO1
|
3.4
|
182.4
|
1.0
|
CA
|
E:3EG2
|
3.4
|
182.4
|
1.0
|
C11
|
E:JMO1
|
3.7
|
182.4
|
1.0
|
N
|
E:3EG2
|
3.7
|
182.4
|
1.0
|
CG
|
A:GLN126
|
4.0
|
213.6
|
1.0
|
CB
|
A:VAL129
|
4.1
|
219.9
|
1.0
|
CG1
|
A:VAL129
|
4.2
|
219.9
|
1.0
|
CA
|
A:GLN126
|
4.2
|
213.6
|
1.0
|
O2
|
E:JMO1
|
4.5
|
182.4
|
1.0
|
CB
|
A:GLN126
|
4.5
|
213.6
|
1.0
|
O
|
A:GLN126
|
4.5
|
213.6
|
1.0
|
CG2
|
A:VAL129
|
4.7
|
219.9
|
1.0
|
O
|
E:LEU6
|
4.7
|
182.4
|
1.0
|
C12
|
E:JMO1
|
4.8
|
182.4
|
1.0
|
C
|
E:3EG2
|
4.9
|
182.4
|
1.0
|
C
|
A:GLN126
|
4.9
|
213.6
|
1.0
|
NE2
|
A:GLN126
|
5.0
|
213.6
|
1.0
|
|
Fluorine binding site 2 out
of 6 in 7zl3
Go back to
Fluorine Binding Sites List in 7zl3
Fluorine binding site 2 out
of 6 in the Signal Peptide Mimicry Primes SEC61 For Client-Selective Inhibition
Mono view
Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Signal Peptide Mimicry Primes SEC61 For Client-Selective Inhibition within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
E:F2
b:182.4
occ:1.00
|
FAD
|
E:3EG2
|
0.0
|
182.4
|
1.0
|
CG
|
E:3EG2
|
1.4
|
182.4
|
1.0
|
FAE
|
E:3EG2
|
2.3
|
182.4
|
1.0
|
FAC
|
E:3EG2
|
2.4
|
182.4
|
1.0
|
CB
|
E:3EG2
|
2.5
|
182.4
|
1.0
|
CG1
|
A:VAL129
|
3.0
|
219.9
|
1.0
|
CB
|
A:VAL129
|
3.7
|
219.9
|
1.0
|
CA
|
E:3EG2
|
3.7
|
182.4
|
1.0
|
CG2
|
A:VAL129
|
4.2
|
219.9
|
1.0
|
C
|
E:3EG2
|
4.7
|
182.4
|
1.0
|
O
|
E:3EG2
|
4.7
|
182.4
|
1.0
|
N
|
E:3EG2
|
4.8
|
182.4
|
1.0
|
O3
|
E:JMO1
|
5.0
|
182.4
|
1.0
|
|
Fluorine binding site 3 out
of 6 in 7zl3
Go back to
Fluorine Binding Sites List in 7zl3
Fluorine binding site 3 out
of 6 in the Signal Peptide Mimicry Primes SEC61 For Client-Selective Inhibition
Mono view
Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Signal Peptide Mimicry Primes SEC61 For Client-Selective Inhibition within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
E:F2
b:182.4
occ:1.00
|
FAE
|
E:3EG2
|
0.0
|
182.4
|
1.0
|
CG
|
E:3EG2
|
1.4
|
182.4
|
1.0
|
FAD
|
E:3EG2
|
2.3
|
182.4
|
1.0
|
FAC
|
E:3EG2
|
2.3
|
182.4
|
1.0
|
CB
|
E:3EG2
|
2.5
|
182.4
|
1.0
|
CA
|
E:3EG2
|
2.7
|
182.4
|
1.0
|
O3
|
E:JMO1
|
3.1
|
182.4
|
1.0
|
CD1
|
E:MLE3
|
3.2
|
182.4
|
1.0
|
N
|
E:3EG2
|
3.6
|
182.4
|
1.0
|
C11
|
E:JMO1
|
3.8
|
182.4
|
1.0
|
C
|
E:3EG2
|
3.9
|
182.4
|
1.0
|
CG
|
E:MLE3
|
4.5
|
182.4
|
1.0
|
O
|
E:3EG2
|
4.5
|
182.4
|
1.0
|
CD2
|
E:MLE3
|
4.6
|
182.4
|
1.0
|
CG1
|
A:VAL129
|
4.7
|
219.9
|
1.0
|
CA
|
E:MLE3
|
4.7
|
182.4
|
1.0
|
N
|
E:MLE3
|
4.8
|
182.4
|
1.0
|
|
Fluorine binding site 4 out
of 6 in 7zl3
Go back to
Fluorine Binding Sites List in 7zl3
Fluorine binding site 4 out
of 6 in the Signal Peptide Mimicry Primes SEC61 For Client-Selective Inhibition
Mono view
Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 4 of Signal Peptide Mimicry Primes SEC61 For Client-Selective Inhibition within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
E:F4
b:182.4
occ:1.00
|
FAC
|
E:3EG4
|
0.0
|
182.4
|
1.0
|
CG
|
E:3EG4
|
1.4
|
182.4
|
1.0
|
FAD
|
E:3EG4
|
2.4
|
182.4
|
1.0
|
FAE
|
E:3EG4
|
2.4
|
182.4
|
1.0
|
CB
|
E:3EG4
|
2.5
|
182.4
|
1.0
|
N
|
E:3EG4
|
2.7
|
182.4
|
1.0
|
OD1
|
A:ASN299
|
3.1
|
134.6
|
1.0
|
CA
|
E:3EG4
|
3.1
|
182.4
|
1.0
|
CB
|
A:SER298
|
3.2
|
138.2
|
1.0
|
C
|
E:MLE3
|
3.6
|
182.4
|
1.0
|
CB
|
E:MLE3
|
3.7
|
182.4
|
1.0
|
CE
|
A:MET64
|
3.8
|
168.0
|
1.0
|
OG
|
A:SER298
|
4.0
|
138.2
|
1.0
|
CG
|
A:ASN299
|
4.2
|
134.6
|
1.0
|
N
|
A:ASN299
|
4.2
|
134.6
|
1.0
|
CA
|
E:MLE3
|
4.3
|
182.4
|
1.0
|
O
|
A:ALA295
|
4.3
|
119.0
|
1.0
|
C
|
A:SER298
|
4.3
|
138.2
|
1.0
|
O
|
E:MLE3
|
4.3
|
182.4
|
1.0
|
CG
|
A:MET64
|
4.3
|
168.0
|
1.0
|
CA
|
A:SER298
|
4.4
|
138.2
|
1.0
|
C
|
E:3EG4
|
4.5
|
182.4
|
1.0
|
CA
|
A:ASN299
|
4.7
|
134.6
|
1.0
|
O
|
E:3EG4
|
4.8
|
182.4
|
1.0
|
SD
|
A:MET64
|
4.8
|
168.0
|
1.0
|
CD1
|
A:ILE67
|
4.9
|
162.0
|
1.0
|
O
|
A:SER298
|
5.0
|
138.2
|
1.0
|
ND2
|
A:ASN299
|
5.0
|
134.6
|
1.0
|
CG
|
E:MLE3
|
5.0
|
182.4
|
1.0
|
|
Fluorine binding site 5 out
of 6 in 7zl3
Go back to
Fluorine Binding Sites List in 7zl3
Fluorine binding site 5 out
of 6 in the Signal Peptide Mimicry Primes SEC61 For Client-Selective Inhibition
Mono view
Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 5 of Signal Peptide Mimicry Primes SEC61 For Client-Selective Inhibition within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
E:F4
b:182.4
occ:1.00
|
FAD
|
E:3EG4
|
0.0
|
182.4
|
1.0
|
CG
|
E:3EG4
|
1.4
|
182.4
|
1.0
|
FAE
|
E:3EG4
|
2.3
|
182.4
|
1.0
|
FAC
|
E:3EG4
|
2.4
|
182.4
|
1.0
|
CB
|
E:3EG4
|
2.5
|
182.4
|
1.0
|
CB
|
A:SER298
|
3.2
|
138.2
|
1.0
|
CD1
|
A:ILE67
|
3.2
|
162.0
|
1.0
|
OG
|
A:SER298
|
3.2
|
138.2
|
1.0
|
CA
|
A:ALA295
|
3.6
|
119.0
|
1.0
|
CA
|
E:3EG4
|
3.9
|
182.4
|
1.0
|
O
|
A:ALA295
|
4.0
|
119.0
|
1.0
|
CB
|
A:ALA295
|
4.1
|
119.0
|
1.0
|
C
|
A:ALA295
|
4.3
|
119.0
|
1.0
|
O
|
A:SER294
|
4.3
|
109.1
|
1.0
|
N
|
E:3EG4
|
4.3
|
182.4
|
1.0
|
CG
|
A:MET64
|
4.4
|
168.0
|
1.0
|
CG1
|
A:ILE67
|
4.4
|
162.0
|
1.0
|
N
|
A:ALA295
|
4.4
|
119.0
|
1.0
|
CA
|
A:SER298
|
4.6
|
138.2
|
1.0
|
OD1
|
A:ASN299
|
4.7
|
134.6
|
1.0
|
C
|
A:SER294
|
4.7
|
109.1
|
1.0
|
C2
|
E:JMX5
|
4.9
|
182.4
|
1.0
|
|
Fluorine binding site 6 out
of 6 in 7zl3
Go back to
Fluorine Binding Sites List in 7zl3
Fluorine binding site 6 out
of 6 in the Signal Peptide Mimicry Primes SEC61 For Client-Selective Inhibition
Mono view
Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 6 of Signal Peptide Mimicry Primes SEC61 For Client-Selective Inhibition within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
E:F4
b:182.4
occ:1.00
|
FAE
|
E:3EG4
|
0.0
|
182.4
|
1.0
|
CG
|
E:3EG4
|
1.4
|
182.4
|
1.0
|
FAD
|
E:3EG4
|
2.3
|
182.4
|
1.0
|
FAC
|
E:3EG4
|
2.4
|
182.4
|
1.0
|
CB
|
E:3EG4
|
2.5
|
182.4
|
1.0
|
CA
|
E:3EG4
|
2.8
|
182.4
|
1.0
|
N
|
E:3EG4
|
3.2
|
182.4
|
1.0
|
CD1
|
A:ILE67
|
3.2
|
162.0
|
1.0
|
CE
|
A:MET64
|
3.5
|
168.0
|
1.0
|
CG
|
A:MET64
|
3.6
|
168.0
|
1.0
|
C
|
E:MLE3
|
3.6
|
182.4
|
1.0
|
O
|
E:MLE3
|
3.6
|
182.4
|
1.0
|
SD
|
A:MET64
|
3.8
|
168.0
|
1.0
|
C15
|
E:JMO1
|
4.1
|
182.4
|
1.0
|
N3
|
E:JMO1
|
4.3
|
182.4
|
1.0
|
C13
|
E:JMO1
|
4.4
|
182.4
|
1.0
|
C14
|
E:JMO1
|
4.4
|
182.4
|
1.0
|
C
|
E:3EG4
|
4.4
|
182.4
|
1.0
|
CG1
|
A:ILE67
|
4.5
|
162.0
|
1.0
|
NE1
|
E:JMX5
|
4.5
|
182.4
|
1.0
|
C2
|
E:JMX5
|
4.5
|
182.4
|
1.0
|
CD1
|
E:JMX5
|
4.5
|
182.4
|
1.0
|
CA
|
E:MLE3
|
4.8
|
182.4
|
1.0
|
CB
|
A:SER298
|
4.8
|
138.2
|
1.0
|
CB
|
A:MET64
|
4.8
|
168.0
|
1.0
|
CB
|
E:MLE3
|
5.0
|
182.4
|
1.0
|
|
Reference:
S.Rehan,
V.Paavilainen O.
Signal Peptide Mimicry Primes SEC61 For Client-Selective Inhibition Nat.Chem.Biol. 2023.
ISSN: ESSN 1552-4469
Page generated: Fri Aug 2 16:17:00 2024
|