Fluorine in PDB 8aym: Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-55511118

The structure of Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-55511118 also contains other interesting chemical elements:

Chlorine

(Cl)

2 atoms

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 18;

Binding sites:

The binding sites of Fluorine atom in the Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-55511118 (pdb code 8aym). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 18 binding sites of Fluorine where determined in the Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-55511118, PDB code: 8aym:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Fluorine binding site 1 out of 18 in the Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-55511118


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-55511118 within 5.0Å range: probe atom residue distance (Å) B Occ I:F501 b:12.3 occ:1.00 F1 I:XVD501 0.0 12.3 1.0 C14 I:XVD501 1.4 12.3 1.0 F3 I:XVD501 2.2 12.3 1.0 F2 I:XVD501 2.2 12.3 1.0 O2 I:XVD501 2.2 12.3 1.0 C5 I:XVD501 3.0 12.3 1.0 C4 I:XVD501 3.2 12.3 1.0 O C:GLU520 3.6 10.4 1.0 CB C:MET523 3.6 9.9 1.0 SG C:CYS524 3.7 8.9 1.0 CA C:GLU520 3.7 10.4 1.0 CB C:GLU520 4.1 10.4 1.0 C C:GLU520 4.1 10.4 1.0 N C:CYS524 4.2 8.9 1.0 CD1 I:ILE180 4.2 11.3 1.0 C6 I:XVD501 4.3 12.3 1.0 CG C:GLU520 4.3 10.4 1.0 C C:MET523 4.5 9.9 1.0 C3 I:XVD501 4.5 12.3 1.0 CG C:MET523 4.6 9.9 1.0 CA C:MET523 4.6 9.9 1.0 CB C:CYS524 4.8 8.9 1.0 CA C:CYS524 4.8 8.9 1.0 C7 I:XVD501 4.8 12.3 1.0 N C:GLU520 4.9 10.4 1.0 O C:TYR519 4.9 10.1 1.0 CE1 I:PHE205 4.9 13.7 1.0

Fluorine binding site 2 out of 18 in the Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-55511118


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-55511118 within 5.0Å range: probe atom residue distance (Å) B Occ I:F501 b:12.3 occ:1.00 F2 I:XVD501 0.0 12.3 1.0 C14 I:XVD501 1.4 12.3 1.0 F3 I:XVD501 2.2 12.3 1.0 F1 I:XVD501 2.2 12.3 1.0 O2 I:XVD501 2.2 12.3 1.0 SG C:CYS524 3.1 8.9 1.0 C5 I:XVD501 3.4 12.3 1.0 CG1 I:VAL176 3.6 11.7 1.0 CG2 I:VAL176 3.7 11.7 1.0 C12 I:XVD501 3.8 12.3 1.0 CD1 I:ILE180 3.8 11.3 1.0 C7 I:XVD501 3.9 12.3 1.0 C6 I:XVD501 4.1 12.3 1.0 CB I:VAL176 4.3 11.7 1.0 C11 I:XVD501 4.3 12.3 1.0 C4 I:XVD501 4.4 12.3 1.0 CZ I:PHE205 4.5 13.7 1.0 C8 I:XVD501 4.6 12.3 1.0 CB C:CYS524 4.6 8.9 1.0 N C:CYS524 4.8 8.9 1.0 CA C:CYS524 4.8 8.9 1.0 CE1 I:PHE205 4.8 13.7 1.0 CD1 I:ILE173 4.8 11.2 1.0 O C:GLU520 4.9 10.4 1.0 C10 I:XVD501 4.9 12.3 1.0 C9 I:XVD501 5.0 12.3 1.0

Fluorine binding site 3 out of 18 in the Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-55511118


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-55511118 within 5.0Å range: probe atom residue distance (Å) B Occ I:F501 b:12.3 occ:1.00 F3 I:XVD501 0.0 12.3 1.0 C14 I:XVD501 1.4 12.3 1.0 F2 I:XVD501 2.2 12.3 1.0 F1 I:XVD501 2.2 12.3 1.0 O2 I:XVD501 2.3 12.3 1.0 C5 I:XVD501 2.5 12.3 1.0 C4 I:XVD501 3.1 12.3 1.0 C6 I:XVD501 3.1 12.3 1.0 C12 I:XVD501 3.3 12.3 1.0 CB C:MET523 3.4 9.9 1.0 C7 I:XVD501 3.5 12.3 1.0 C C:MET523 3.7 9.9 1.0 N C:CYS524 3.8 8.9 1.0 O C:MET523 3.9 9.9 1.0 SG C:CYS524 4.0 8.9 1.0 C3 I:XVD501 4.1 12.3 1.0 C1 I:XVD501 4.1 12.3 1.0 CD1 C:PHE527 4.1 9.8 1.0 CA C:MET523 4.2 9.9 1.0 CE1 C:PHE527 4.2 9.8 1.0 CA C:CYS524 4.2 8.9 1.0 C11 I:XVD501 4.4 12.3 1.0 C2 I:XVD501 4.5 12.3 1.0 CG C:MET523 4.5 9.9 1.0 CG C:PHE527 4.6 9.8 1.0 C8 I:XVD501 4.7 12.3 1.0 CZ C:PHE527 4.7 9.8 1.0 CB C:CYS524 4.8 8.9 1.0 O C:GLU520 4.8 10.4 1.0

Fluorine binding site 4 out of 18 in the Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-55511118


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-55511118 within 5.0Å range: probe atom residue distance (Å) B Occ C:F901 b:42.1 occ:1.00 FAF C:ZK1901 0.0 42.1 1.0 CAZ C:ZK1901 1.4 42.1 1.0 FAG C:ZK1901 2.2 42.1 1.0 FAH C:ZK1901 2.2 42.1 1.0 CAS C:ZK1901 2.4 42.1 1.0 CAJ C:ZK1901 2.6 42.1 1.0 OH C:TYR446 3.2 42.4 1.0 CG C:GLU398 3.4 43.6 1.0 CG C:PRO474 3.4 36.2 1.0 CAR C:ZK1901 3.6 42.1 1.0 CE2 C:TYR401 3.8 38.5 1.0 CAV C:ZK1901 3.9 42.1 1.0 CZ C:TYR446 4.0 42.4 1.0 CD2 C:TYR401 4.0 38.5 1.0 CB C:PRO474 4.1 36.2 1.0 CB C:GLU398 4.1 43.6 1.0 CE1 C:TYR446 4.2 42.4 1.0 OH C:TYR728 4.4 32.7 1.0 CD C:GLU398 4.5 43.6 1.0 CAM C:ZK1901 4.5 42.1 1.0 CE C:MET704 4.6 42.8 1.0 NAX C:ZK1901 4.6 42.1 1.0 CAI C:ZK1901 4.7 42.1 1.0 CZ C:TYR401 4.7 38.5 1.0 NAP C:ZK1901 4.7 42.1 1.0 CD C:PRO474 4.8 36.2 1.0 OE1 C:GLU398 4.8 43.6 1.0 CAW C:ZK1901 4.8 42.1 1.0 CZ C:TYR728 4.8 32.7 1.0 CE2 C:TYR446 5.0 42.4 1.0 CE1 C:TYR728 5.0 32.7 1.0

Fluorine binding site 5 out of 18 in the Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-55511118


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 5 of Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-55511118 within 5.0Å range: probe atom residue distance (Å) B Occ C:F901 b:42.1 occ:1.00 FAG C:ZK1901 0.0 42.1 1.0 CAZ C:ZK1901 1.4 42.1 1.0 FAH C:ZK1901 2.2 42.1 1.0 FAF C:ZK1901 2.2 42.1 1.0 CAS C:ZK1901 2.3 42.1 1.0 CAR C:ZK1901 3.1 42.1 1.0 CAM C:ZK1901 3.4 42.1 1.0 CAN C:ZK1901 3.4 42.1 1.0 CAJ C:ZK1901 3.4 42.1 1.0 CE C:MET704 3.5 42.8 1.0 NAX C:ZK1901 3.5 42.1 1.0 CG C:MET704 3.6 42.8 1.0 CG C:GLU398 3.7 43.6 1.0 SD C:MET704 3.9 42.8 1.0 CAL C:ZK1901 4.1 42.1 1.0 CD C:GLU398 4.3 43.6 1.0 OH C:TYR728 4.4 32.7 1.0 OH C:TYR446 4.4 42.4 1.0 CE2 C:TYR401 4.4 38.5 1.0 CAI C:ZK1901 4.5 42.1 1.0 CAK C:ZK1901 4.5 42.1 1.0 OE1 C:GLU398 4.6 43.6 1.0 CAV C:ZK1901 4.7 42.1 1.0 OE2 C:GLU398 4.9 43.6 1.0 OAQ C:ZK1901 4.9 42.1 1.0 CB C:MET704 5.0 42.8 1.0 OG1 C:THR703 5.0 38.8 1.0

Fluorine binding site 6 out of 18 in the Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-55511118


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 6 of Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-55511118 within 5.0Å range: probe atom residue distance (Å) B Occ C:F901 b:42.1 occ:1.00 FAH C:ZK1901 0.0 42.1 1.0 CAZ C:ZK1901 1.4 42.1 1.0 FAG C:ZK1901 2.2 42.1 1.0 FAF C:ZK1901 2.2 42.1 1.0 OH C:TYR728 2.3 32.7 1.0 CAS C:ZK1901 2.4 42.1 1.0 CAJ C:ZK1901 2.6 42.1 1.0 CZ C:TYR728 3.1 32.7 1.0 CE1 C:TYR728 3.5 32.7 1.0 CAR C:ZK1901 3.6 42.1 1.0 CAV C:ZK1901 3.9 42.1 1.0 CE2 C:TYR401 4.0 38.5 1.0 OG1 C:THR703 4.1 38.8 1.0 CE2 C:TYR728 4.1 32.7 1.0 OH C:TYR401 4.1 38.5 1.0 CE C:MET704 4.3 42.8 1.0 CB C:PRO474 4.4 36.2 1.0 CZ C:TYR401 4.4 38.5 1.0 CAN C:ZK1901 4.4 42.1 1.0 CG C:PRO474 4.5 36.2 1.0 NAX C:ZK1901 4.6 42.1 1.0 CAI C:ZK1901 4.6 42.1 1.0 CD1 C:TYR728 4.7 32.7 1.0 NAP C:ZK1901 4.8 42.1 1.0 CAW C:ZK1901 4.8 42.1 1.0 CG C:MET704 4.9 42.8 1.0 CD2 C:TYR401 4.9 38.5 1.0 CAM C:ZK1901 5.0 42.1 1.0

Fluorine binding site 7 out of 18 in the Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-55511118


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 7 of Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-55511118 within 5.0Å range: probe atom residue distance (Å) B Occ D:F901 b:46.9 occ:1.00 FAF D:ZK1901 0.0 46.9 1.0 CAZ D:ZK1901 1.4 46.9 1.0 FAH D:ZK1901 2.2 46.9 1.0 FAG D:ZK1901 2.2 46.9 1.0 CAS D:ZK1901 2.3 46.9 1.0 CAR D:ZK1901 3.1 46.9 1.0 CAN D:ZK1901 3.4 46.9 1.0 CE D:MET708 3.4 45.7 1.0 CAJ D:ZK1901 3.4 46.9 1.0 NAX D:ZK1901 3.5 46.9 1.0 CG D:MET708 3.6 45.7 1.0 CAM D:ZK1901 3.6 46.9 1.0 OE1 D:GLU402 3.6 54.1 1.0 SD D:MET708 3.7 45.7 1.0 CE1 D:TYR405 4.3 51.5 1.0 CAI D:ZK1901 4.4 46.9 1.0 OH D:TYR732 4.5 40.9 1.0 CD D:GLU402 4.5 54.1 1.0 OG1 D:THR707 4.5 42.9 1.0 CAK D:ZK1901 4.6 46.9 1.0 OE1 D:GLU705 4.6 41.0 1.0 CAL D:ZK1901 4.6 46.9 1.0 CAV D:ZK1901 4.7 46.9 1.0 OE2 D:GLU402 4.8 54.1 1.0 CD1 D:TYR405 5.0 51.5 1.0

Fluorine binding site 8 out of 18 in the Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-55511118


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 8 of Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-55511118 within 5.0Å range: probe atom residue distance (Å) B Occ D:F901 b:46.9 occ:1.00 FAG D:ZK1901 0.0 46.9 1.0 CAZ D:ZK1901 1.4 46.9 1.0 FAF D:ZK1901 2.2 46.9 1.0 FAH D:ZK1901 2.2 46.9 1.0 CAS D:ZK1901 2.4 46.9 1.0 OH D:TYR732 2.4 40.9 1.0 CAJ D:ZK1901 2.6 46.9 1.0 CZ D:TYR732 3.2 40.9 1.0 OE1 D:GLU705 3.4 41.0 1.0 CAR D:ZK1901 3.6 46.9 1.0 CE1 D:TYR405 3.6 51.5 1.0 CE2 D:TYR732 3.9 40.9 1.0 CAV D:ZK1901 3.9 46.9 1.0 OG1 D:THR707 3.9 42.9 1.0 OH D:TYR405 4.0 51.5 1.0 CE1 D:TYR732 4.0 40.9 1.0 CZ D:TYR405 4.3 51.5 1.0 CB D:PRO478 4.4 49.2 1.0 CD D:GLU705 4.5 41.0 1.0 NAX D:ZK1901 4.6 46.9 1.0 CAM D:ZK1901 4.6 46.9 1.0 CD1 D:TYR405 4.6 51.5 1.0 CE D:MET708 4.6 45.7 1.0 CAI D:ZK1901 4.6 46.9 1.0 NAP D:ZK1901 4.8 46.9 1.0 CAW D:ZK1901 4.8 46.9 1.0 CG D:PRO478 5.0 49.2 1.0

Fluorine binding site 9 out of 18 in the Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-55511118


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 9 of Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-55511118 within 5.0Å range: probe atom residue distance (Å) B Occ D:F901 b:46.9 occ:1.00 FAH D:ZK1901 0.0 46.9 1.0 CAZ D:ZK1901 1.4 46.9 1.0 FAF D:ZK1901 2.2 46.9 1.0 FAG D:ZK1901 2.2 46.9 1.0 CAS D:ZK1901 2.4 46.9 1.0 CAJ D:ZK1901 2.6 46.9 1.0 OH D:TYR450 3.3 53.7 1.0 CE1 D:TYR405 3.3 51.5 1.0 CAR D:ZK1901 3.6 46.9 1.0 CG D:PRO478 3.6 49.2 1.0 CD1 D:TYR405 3.7 51.5 1.0 OE1 D:GLU402 3.7 54.1 1.0 CB D:PRO478 3.8 49.2 1.0 CD D:GLU402 3.9 54.1 1.0 CAV D:ZK1901 3.9 46.9 1.0 OE2 D:GLU402 4.0 54.1 1.0 CZ D:TYR450 4.4 53.7 1.0 CB D:GLU402 4.5 54.1 1.0 CZ D:TYR405 4.5 51.5 1.0 OH D:TYR732 4.5 40.9 1.0 CAN D:ZK1901 4.6 46.9 1.0 NAX D:ZK1901 4.6 46.9 1.0 CAI D:ZK1901 4.7 46.9 1.0 O D:PRO478 4.7 49.2 1.0 CE D:MET708 4.7 45.7 1.0 NAP D:ZK1901 4.7 46.9 1.0 CG D:GLU402 4.8 54.1 1.0 CAW D:ZK1901 4.8 46.9 1.0 OH D:TYR405 4.9 51.5 1.0 CZ D:TYR732 5.0 40.9 1.0

Fluorine binding site 10 out of 18 in the Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-55511118


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 10 of Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-55511118 within 5.0Å range: probe atom residue distance (Å) B Occ B:F901 b:47.3 occ:1.00 FAF B:ZK1901 0.0 47.3 1.0 CAZ B:ZK1901 1.4 47.3 1.0 FAH B:ZK1901 2.2 47.3 1.0 FAG B:ZK1901 2.2 47.3 1.0 CAS B:ZK1901 2.3 47.3 1.0 CAR B:ZK1901 3.1 47.3 1.0 SD B:MET708 3.4 46.3 1.0 CAN B:ZK1901 3.4 47.3 1.0 CAJ B:ZK1901 3.4 47.3 1.0 NAX B:ZK1901 3.5 47.3 1.0 CG B:MET708 3.6 46.3 1.0 CAM B:ZK1901 3.6 47.3 1.0 OE1 B:GLU402 3.6 54.2 1.0 CE B:MET708 3.7 46.3 1.0 CE1 B:TYR405 4.2 51.6 1.0 OH B:TYR732 4.4 41.2 1.0 CAI B:ZK1901 4.5 47.3 1.0 CD B:GLU402 4.5 54.2 1.0 OG1 B:THR707 4.5 43.3 1.0 OE1 B:GLU705 4.6 41.5 1.0 CAK B:ZK1901 4.6 47.3 1.0 CAL B:ZK1901 4.7 47.3 1.0 CAV B:ZK1901 4.7 47.3 1.0 OE2 B:GLU402 4.8 54.2 1.0 CD1 B:TYR405 5.0 51.6 1.0

D.Zhang, R.Lape, S.A.Shaikh, B.K.Kohegyi, J.F.Watson, O.Cais, T.Nakagawa, I.H.Greger. Modulatory Mechanisms of Tarp Gamma 8-Selective Ampa Receptor Therapeutics. Nat Commun V. 14 1659 2023.
ISSN: ESSN 2041-1723
PubMed: 36966141
DOI: 10.1038/S41467-023-37259-5