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Fluorine in PDB 8ayn: Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand LY3130481

Fluorine Binding Sites:

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>>> Page 1 <<< Page 2, Binding sites: 11 - 12;

Binding sites:

The binding sites of Fluorine atom in the Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand LY3130481 (pdb code 8ayn). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 12 binding sites of Fluorine where determined in the Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand LY3130481, PDB code: 8ayn:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Fluorine binding site 1 out of 12 in 8ayn

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Fluorine binding site 1 out of 12 in the Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand LY3130481


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand LY3130481 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:F901

b:63.2
occ:1.00
FAF B:ZK1901 0.0 63.2 1.0
CAZ B:ZK1901 1.4 63.2 1.0
FAG B:ZK1901 2.2 63.2 1.0
FAH B:ZK1901 2.2 63.2 1.0
CAS B:ZK1901 2.4 63.2 1.0
CAR B:ZK1901 3.1 63.2 1.0
CAJ B:ZK1901 3.4 63.2 1.0
CAN B:ZK1901 3.5 63.2 1.0
NAX B:ZK1901 3.6 63.2 1.0
CAM B:ZK1901 3.6 63.2 1.0
CE B:MET708 3.7 60.4 1.0
CG B:GLU402 3.9 70.2 1.0
CAL B:ZK1901 3.9 63.2 1.0
CD B:GLU402 4.4 70.2 1.0
OH B:TYR732 4.4 53.4 1.0
CAK B:ZK1901 4.5 63.2 1.0
CAI B:ZK1901 4.5 63.2 1.0
OE1 B:GLU402 4.6 70.2 1.0
CAV B:ZK1901 4.7 63.2 1.0
CE2 B:TYR405 4.7 67.2 1.0
OAQ B:ZK1901 4.8 63.2 1.0
CB B:MET708 4.9 60.4 1.0
OH B:TYR450 5.0 69.1 1.0

Fluorine binding site 2 out of 12 in 8ayn

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Fluorine binding site 2 out of 12 in the Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand LY3130481


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand LY3130481 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:F901

b:63.2
occ:1.00
FAG B:ZK1901 0.0 63.2 1.0
CAZ B:ZK1901 1.4 63.2 1.0
FAF B:ZK1901 2.2 63.2 1.0
FAH B:ZK1901 2.2 63.2 1.0
CAS B:ZK1901 2.4 63.2 1.0
OH B:TYR732 2.4 53.4 1.0
CAJ B:ZK1901 2.6 63.2 1.0
CZ B:TYR732 3.2 53.4 1.0
CAR B:ZK1901 3.6 63.2 1.0
CE1 B:TYR732 3.7 53.4 1.0
CAV B:ZK1901 3.8 63.2 1.0
CB B:PRO478 4.1 62.9 1.0
CE2 B:TYR732 4.2 53.4 1.0
CE2 B:TYR405 4.3 67.2 1.0
OG1 B:THR707 4.5 55.7 1.0
CAM B:ZK1901 4.5 63.2 1.0
CG B:PRO478 4.6 62.9 1.0
O B:PRO478 4.6 62.9 1.0
CAI B:ZK1901 4.6 63.2 1.0
NAX B:ZK1901 4.6 63.2 1.0
NAP B:ZK1901 4.7 63.2 1.0
CAW B:ZK1901 4.7 63.2 1.0
CD1 B:TYR732 4.9 53.4 1.0
OH B:TYR405 4.9 67.2 1.0

Fluorine binding site 3 out of 12 in 8ayn

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Fluorine binding site 3 out of 12 in the Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand LY3130481


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand LY3130481 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:F901

b:63.2
occ:1.00
FAH B:ZK1901 0.0 63.2 1.0
CAZ B:ZK1901 1.4 63.2 1.0
FAF B:ZK1901 2.2 63.2 1.0
FAG B:ZK1901 2.2 63.2 1.0
CAS B:ZK1901 2.4 63.2 1.0
CAJ B:ZK1901 2.5 63.2 1.0
OH B:TYR450 3.1 69.1 1.0
CG B:PRO478 3.5 62.9 1.0
CG B:GLU402 3.6 70.2 1.0
CAR B:ZK1901 3.6 63.2 1.0
CB B:PRO478 3.8 62.9 1.0
CAV B:ZK1901 3.8 63.2 1.0
CZ B:TYR450 4.0 69.1 1.0
CB B:GLU402 4.2 70.2 1.0
CE2 B:TYR405 4.2 67.2 1.0
CD2 B:TYR405 4.4 67.2 1.0
O B:PRO478 4.4 62.9 1.0
CD B:GLU402 4.4 70.2 1.0
OE1 B:GLU402 4.4 70.2 1.0
OH B:TYR732 4.5 53.4 1.0
CE2 B:TYR450 4.5 69.1 1.0
CAN B:ZK1901 4.5 63.2 1.0
CAI B:ZK1901 4.6 63.2 1.0
NAX B:ZK1901 4.6 63.2 1.0
NAP B:ZK1901 4.7 63.2 1.0
CAW B:ZK1901 4.7 63.2 1.0
CE1 B:TYR450 4.8 69.1 1.0
CD B:PRO478 4.9 62.9 1.0

Fluorine binding site 4 out of 12 in 8ayn

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Fluorine binding site 4 out of 12 in the Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand LY3130481


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand LY3130481 within 5.0Å range:
probe atom residue distance (Å) B Occ
D:F901

b:62.7
occ:1.00
FAF D:ZK1901 0.0 62.7 1.0
CAZ D:ZK1901 1.4 62.7 1.0
FAG D:ZK1901 2.2 62.7 1.0
FAH D:ZK1901 2.2 62.7 1.0
CAS D:ZK1901 2.4 62.7 1.0
CAR D:ZK1901 3.2 62.7 1.0
CAL D:ZK1901 3.3 62.7 1.0
CAJ D:ZK1901 3.4 62.7 1.0
CE D:MET708 3.4 60.6 1.0
CAK D:ZK1901 3.6 62.7 1.0
NAX D:ZK1901 3.7 62.7 1.0
CAN D:ZK1901 3.7 62.7 1.0
OAQ D:ZK1901 3.9 62.7 1.0
CG D:GLU402 3.9 69.7 1.0
CAM D:ZK1901 4.0 62.7 1.0
CD D:GLU402 4.4 69.7 1.0
CAI D:ZK1901 4.5 62.7 1.0
CB D:MET708 4.6 60.6 1.0
OE1 D:GLU402 4.7 69.7 1.0
CAV D:ZK1901 4.7 62.7 1.0
OH D:TYR732 4.7 53.3 1.0
CE2 D:TYR405 4.9 66.2 1.0
OE2 D:GLU402 4.9 69.7 1.0
SD D:MET708 4.9 60.6 1.0
OG1 D:THR707 5.0 55.1 1.0

Fluorine binding site 5 out of 12 in 8ayn

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Fluorine binding site 5 out of 12 in the Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand LY3130481


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 5 of Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand LY3130481 within 5.0Å range:
probe atom residue distance (Å) B Occ
D:F901

b:62.7
occ:1.00
FAG D:ZK1901 0.0 62.7 1.0
CAZ D:ZK1901 1.4 62.7 1.0
FAF D:ZK1901 2.2 62.7 1.0
FAH D:ZK1901 2.2 62.7 1.0
CAS D:ZK1901 2.4 62.7 1.0
CAJ D:ZK1901 2.5 62.7 1.0
OH D:TYR732 2.6 53.3 1.0
CZ D:TYR732 3.5 53.3 1.0
CAR D:ZK1901 3.6 62.7 1.0
CAV D:ZK1901 3.8 62.7 1.0
OG1 D:THR707 4.0 55.1 1.0
CE1 D:TYR732 4.0 53.3 1.0
CE2 D:TYR405 4.3 66.2 1.0
CE2 D:TYR732 4.5 53.3 1.0
CAI D:ZK1901 4.6 62.7 1.0
NAX D:ZK1901 4.7 62.7 1.0
NAP D:ZK1901 4.7 62.7 1.0
CAW D:ZK1901 4.7 62.7 1.0
CB D:PRO478 4.7 63.4 1.0
CG D:PRO478 4.8 63.4 1.0
CAK D:ZK1901 4.8 62.7 1.0
CAM D:ZK1901 4.9 62.7 1.0
OH D:TYR405 4.9 66.2 1.0

Fluorine binding site 6 out of 12 in 8ayn

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Fluorine binding site 6 out of 12 in the Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand LY3130481


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 6 of Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand LY3130481 within 5.0Å range:
probe atom residue distance (Å) B Occ
D:F901

b:62.7
occ:1.00
FAH D:ZK1901 0.0 62.7 1.0
CAZ D:ZK1901 1.4 62.7 1.0
FAG D:ZK1901 2.2 62.7 1.0
FAF D:ZK1901 2.2 62.7 1.0
CAS D:ZK1901 2.4 62.7 1.0
CAJ D:ZK1901 2.5 62.7 1.0
OH D:TYR450 3.3 68.1 1.0
CG D:GLU402 3.4 69.7 1.0
CAR D:ZK1901 3.6 62.7 1.0
CG D:PRO478 3.8 63.4 1.0
CAV D:ZK1901 3.8 62.7 1.0
CE2 D:TYR405 4.0 66.2 1.0
CZ D:TYR450 4.1 68.1 1.0
CB D:GLU402 4.2 69.7 1.0
CD2 D:TYR405 4.2 66.2 1.0
CD D:GLU402 4.3 69.7 1.0
CB D:PRO478 4.4 63.4 1.0
CE2 D:TYR450 4.4 68.1 1.0
OE1 D:GLU402 4.4 69.7 1.0
OH D:TYR732 4.5 53.3 1.0
CAI D:ZK1901 4.6 62.7 1.0
NAP D:ZK1901 4.6 62.7 1.0
NAX D:ZK1901 4.7 62.7 1.0
CAW D:ZK1901 4.7 62.7 1.0
CAN D:ZK1901 4.8 62.7 1.0
O D:PRO478 4.9 63.4 1.0
CAL D:ZK1901 4.9 62.7 1.0

Fluorine binding site 7 out of 12 in 8ayn

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Fluorine binding site 7 out of 12 in the Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand LY3130481


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 7 of Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand LY3130481 within 5.0Å range:
probe atom residue distance (Å) B Occ
C:F901

b:55.0
occ:1.00
FAF C:ZK1901 0.0 55.0 1.0
CAZ C:ZK1901 1.4 55.0 1.0
FAG C:ZK1901 2.2 55.0 1.0
FAH C:ZK1901 2.2 55.0 1.0
CAS C:ZK1901 2.4 55.0 1.0
CAJ C:ZK1901 2.5 55.0 1.0
OH C:TYR446 3.0 56.9 1.0
CG C:PRO474 3.2 48.1 1.0
CB C:PRO474 3.4 48.1 1.0
CG C:GLU398 3.6 56.4 1.0
CAR C:ZK1901 3.7 55.0 1.0
CAV C:ZK1901 3.8 55.0 1.0
CZ C:TYR446 3.8 56.9 1.0
CE1 C:TYR401 4.0 51.2 1.0
CE2 C:TYR446 4.3 56.9 1.0
CD1 C:TYR401 4.3 51.2 1.0
CB C:GLU398 4.3 56.4 1.0
O C:PRO474 4.3 48.1 1.0
CD C:GLU398 4.4 56.4 1.0
OH C:TYR728 4.4 42.5 1.0
OE1 C:GLU398 4.5 56.4 1.0
CAM C:ZK1901 4.6 55.0 1.0
NAP C:ZK1901 4.6 55.0 1.0
CAI C:ZK1901 4.7 55.0 1.0
NAX C:ZK1901 4.7 55.0 1.0
CD C:PRO474 4.7 48.1 1.0
CAW C:ZK1901 4.7 55.0 1.0
CE1 C:TYR446 4.8 56.9 1.0
CZ C:TYR401 4.8 51.2 1.0
CA C:PRO474 4.8 48.1 1.0
CZ C:TYR728 4.8 42.5 1.0
CE2 C:TYR728 5.0 42.5 1.0

Fluorine binding site 8 out of 12 in 8ayn

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Fluorine binding site 8 out of 12 in the Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand LY3130481


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 8 of Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand LY3130481 within 5.0Å range:
probe atom residue distance (Å) B Occ
C:F901

b:55.0
occ:1.00
FAG C:ZK1901 0.0 55.0 1.0
CAZ C:ZK1901 1.4 55.0 1.0
FAH C:ZK1901 2.2 55.0 1.0
FAF C:ZK1901 2.2 55.0 1.0
CAS C:ZK1901 2.4 55.0 1.0
CAR C:ZK1901 3.1 55.0 1.0
SD C:MET704 3.4 53.8 1.0
CAM C:ZK1901 3.4 55.0 1.0
CAN C:ZK1901 3.4 55.0 1.0
CAJ C:ZK1901 3.4 55.0 1.0
NAX C:ZK1901 3.5 55.0 1.0
CG C:MET704 3.6 53.8 1.0
CG C:GLU398 3.6 56.4 1.0
CD C:GLU398 4.0 56.4 1.0
OAQ C:ZK1901 4.1 55.0 1.0
CAK C:ZK1901 4.2 55.0 1.0
OH C:TYR446 4.2 56.9 1.0
CAL C:ZK1901 4.3 55.0 1.0
OE1 C:GLU398 4.4 56.4 1.0
CE1 C:TYR401 4.4 51.2 1.0
OE2 C:GLU398 4.4 56.4 1.0
CAI C:ZK1901 4.5 55.0 1.0
OH C:TYR728 4.6 42.5 1.0
CAV C:ZK1901 4.7 55.0 1.0
CE C:MET704 4.9 53.8 1.0
CB C:GLU398 4.9 56.4 1.0

Fluorine binding site 9 out of 12 in 8ayn

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Fluorine binding site 9 out of 12 in the Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand LY3130481


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 9 of Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand LY3130481 within 5.0Å range:
probe atom residue distance (Å) B Occ
C:F901

b:55.0
occ:1.00
FAH C:ZK1901 0.0 55.0 1.0
CAZ C:ZK1901 1.4 55.0 1.0
FAG C:ZK1901 2.2 55.0 1.0
FAF C:ZK1901 2.2 55.0 1.0
CAS C:ZK1901 2.4 55.0 1.0
OH C:TYR728 2.5 42.5 1.0
CAJ C:ZK1901 2.6 55.0 1.0
CZ C:TYR728 3.3 42.5 1.0
CAR C:ZK1901 3.6 55.0 1.0
CE2 C:TYR728 3.7 42.5 1.0
CAV C:ZK1901 3.9 55.0 1.0
CB C:PRO474 4.1 48.1 1.0
OG1 C:THR703 4.2 48.4 1.0
CAN C:ZK1901 4.3 55.0 1.0
CE1 C:TYR401 4.3 51.2 1.0
CE1 C:TYR728 4.3 42.5 1.0
OH C:TYR401 4.3 51.2 1.0
NAX C:ZK1901 4.5 55.0 1.0
CAI C:ZK1901 4.6 55.0 1.0
CZ C:TYR401 4.6 51.2 1.0
CG C:PRO474 4.6 48.1 1.0
CG C:MET704 4.6 53.8 1.0
CAW C:ZK1901 4.8 55.0 1.0
NAP C:ZK1901 4.8 55.0 1.0
O C:PRO474 4.9 48.1 1.0
SD C:MET704 4.9 53.8 1.0
CD2 C:TYR728 4.9 42.5 1.0
OH C:TYR446 4.9 56.9 1.0
CAM C:ZK1901 5.0 55.0 1.0
CB C:GLU701 5.0 48.5 1.0

Fluorine binding site 10 out of 12 in 8ayn

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Fluorine binding site 10 out of 12 in the Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand LY3130481


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 10 of Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand LY3130481 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F901

b:55.1
occ:1.00
FAF A:ZK1901 0.0 55.1 1.0
CAZ A:ZK1901 1.4 55.1 1.0
FAG A:ZK1901 2.2 55.1 1.0
FAH A:ZK1901 2.2 55.1 1.0
CAS A:ZK1901 2.4 55.1 1.0
CAJ A:ZK1901 2.5 55.1 1.0
OH A:TYR446 3.0 57.8 1.0
CG A:PRO474 3.2 48.6 1.0
CB A:PRO474 3.4 48.6 1.0
CG A:GLU398 3.6 57.4 1.0
CAR A:ZK1901 3.7 55.1 1.0
CAV A:ZK1901 3.8 55.1 1.0
CZ A:TYR446 3.8 57.8 1.0
CE1 A:TYR401 3.9 52.1 1.0
CD1 A:TYR401 4.2 52.1 1.0
CE2 A:TYR446 4.2 57.8 1.0
CB A:GLU398 4.3 57.4 1.0
O A:PRO474 4.4 48.6 1.0
CD A:GLU398 4.4 57.4 1.0
OH A:TYR728 4.4 43.0 1.0
OE1 A:GLU398 4.5 57.4 1.0
CAM A:ZK1901 4.6 55.1 1.0
NAP A:ZK1901 4.6 55.1 1.0
CAI A:ZK1901 4.7 55.1 1.0
NAX A:ZK1901 4.7 55.1 1.0
CD A:PRO474 4.7 48.6 1.0
CZ A:TYR401 4.7 52.1 1.0
CAW A:ZK1901 4.7 55.1 1.0
CE1 A:TYR446 4.8 57.8 1.0
CA A:PRO474 4.8 48.6 1.0
CZ A:TYR728 4.8 43.0 1.0
CE2 A:TYR728 5.0 43.0 1.0

Reference:

D.Zhang, R.Lape, S.A.Shaikh, B.K.Kohegyi, J.F.Watson, O.Cais, T.Nakagawa, I.H.Greger. Modulatory Mechanisms of Tarp Gamma 8-Selective Ampa Receptor Therapeutics. Nat Commun V. 14 1659 2023.
ISSN: ESSN 2041-1723
PubMed: 36966141
DOI: 10.1038/S41467-023-37259-5
Page generated: Wed Jul 16 02:43:36 2025

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