Fluorine in PDB 8d3y: Human ALPHA3 Na+/K+-Atpase in Its Exoplasmic Side-Open State

All present enzymatic activity of Human ALPHA3 Na+/K+-Atpase in Its Exoplasmic Side-Open State:
7.2.2.13;

The binding sites of Fluorine atom in the Human ALPHA3 Na+/K+-Atpase in Its Exoplasmic Side-Open State (pdb code 8d3y). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Human ALPHA3 Na+/K+-Atpase in Its Exoplasmic Side-Open State, PDB code: 8d3y:
Jump to Fluorine binding site number: 1; 2; 3;

Fluorine binding site 1 out of 3 in the Human ALPHA3 Na+/K+-Atpase in Its Exoplasmic Side-Open State


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Human ALPHA3 Na+/K+-Atpase in Its Exoplasmic Side-Open State within 5.0Å range: probe atom residue distance (Å) B Occ A:F366 b:39.7 occ:1.00 F1 A:BFD366 0.0 39.7 1.0 BE A:BFD366 1.5 39.7 1.0 OD1 A:BFD366 2.4 39.7 1.0 F2 A:BFD366 2.4 39.7 1.0 F3 A:BFD366 2.5 39.7 1.0 ND2 A:ASN710 3.0 49.8 1.0 CG A:BFD366 3.5 39.7 1.0 NZ A:LYS688 3.5 49.8 1.0 OD1 A:ASN710 3.7 49.8 1.0 CG A:ASN710 3.7 49.8 1.0 OG1 A:THR607 4.0 50.5 1.0 N A:GLY608 4.1 58.9 1.0 CA A:GLY210 4.2 66.8 1.0 OD2 A:BFD366 4.2 39.7 1.0 CA A:THR607 4.2 50.5 1.0 CE A:LYS688 4.3 49.8 1.0 CB A:BFD366 4.5 39.7 1.0 C A:THR607 4.5 50.5 1.0 CB A:THR607 4.6 50.5 1.0 OG1 A:THR368 4.8 48.4 1.0 N A:GLY210 4.9 66.8 1.0 O A:VAL606 5.0 40.4 1.0

Fluorine binding site 2 out of 3 in the Human ALPHA3 Na+/K+-Atpase in Its Exoplasmic Side-Open State


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Human ALPHA3 Na+/K+-Atpase in Its Exoplasmic Side-Open State within 5.0Å range: probe atom residue distance (Å) B Occ A:F366 b:39.7 occ:1.00 F2 A:BFD366 0.0 39.7 1.0 BE A:BFD366 1.5 39.7 1.0 F1 A:BFD366 2.4 39.7 1.0 F3 A:BFD366 2.5 39.7 1.0 OD1 A:BFD366 2.6 39.7 1.0 CG A:BFD366 3.0 39.7 1.0 O A:THR368 3.4 48.4 1.0 OD1 A:ASN710 3.6 49.8 1.0 OD2 A:BFD366 3.8 39.7 1.0 OG1 A:THR368 3.9 48.4 1.0 N A:GLY708 3.9 47.7 1.0 CB A:BFD366 4.0 39.7 1.0 ND2 A:ASN710 4.2 49.8 1.0 CA A:GLY708 4.2 47.7 1.0 CG A:ASN710 4.3 49.8 1.0 C A:THR368 4.5 48.4 1.0 CA A:GLY210 4.7 66.8 1.0 N A:ASP707 4.8 44.2 1.0 N A:THR368 4.9 48.4 1.0 O A:SER206 5.0 69.4 1.0

Fluorine binding site 3 out of 3 in the Human ALPHA3 Na+/K+-Atpase in Its Exoplasmic Side-Open State


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Human ALPHA3 Na+/K+-Atpase in Its Exoplasmic Side-Open State within 5.0Å range: probe atom residue distance (Å) B Occ A:F366 b:39.7 occ:1.00 F3 A:BFD366 0.0 39.7 1.0 BE A:BFD366 1.5 39.7 1.0 OD1 A:BFD366 2.5 39.7 1.0 F2 A:BFD366 2.5 39.7 1.0 F1 A:BFD366 2.5 39.7 1.0 OG1 A:THR368 2.9 48.4 1.0 N A:THR368 3.2 48.4 1.0 O A:THR368 3.4 48.4 1.0 CG A:BFD366 3.4 39.7 1.0 OG1 A:THR607 3.5 50.5 1.0 N A:LYS367 3.5 47.2 1.0 CB A:THR368 3.9 48.4 1.0 CA A:THR368 3.9 48.4 1.0 CB A:BFD366 3.9 39.7 1.0 C A:LYS367 4.0 47.2 1.0 CA A:LYS367 4.1 47.2 1.0 C A:THR368 4.1 48.4 1.0 CB A:LYS367 4.1 47.2 1.0 O A:GLY210 4.1 66.8 1.0 CA A:GLY210 4.1 66.8 1.0 CG2 A:THR368 4.4 48.4 1.0 C A:BFD366 4.5 39.7 1.0 CB A:THR607 4.5 50.5 1.0 C A:GLY210 4.5 66.8 1.0 CA A:BFD366 4.6 39.7 1.0 OD2 A:BFD366 4.6 39.7 1.0 O A:BFD366 4.8 39.7 1.0 CA A:THR607 4.8 50.5 1.0 N A:GLY608 4.9 58.9 1.0

P.T.Nguyen, C.Deisl, M.Fine, T.S.Tippetts, E.Uchikawa, X.C.Bai, B.Levine. Structural Basis For Gating Mechanism of the Human Sodium-Potassium Pump. Nat Commun V. 13 5293 2022.
ISSN: ESSN 2041-1723
PubMed: 36075933
DOI: 10.1038/S41467-022-32990-X