Fluorine in PDB 8fwu: Structure of the Ligand-Binding and Transmembrane Domains of Kainate Receptor GLUK2 in Complex with the Positive Allosteric Modulator BPAM344 and Competitive Antagonist Dnqx

Other elements in 8fwu:

The structure of Structure of the Ligand-Binding and Transmembrane Domains of Kainate Receptor GLUK2 in Complex with the Positive Allosteric Modulator BPAM344 and Competitive Antagonist Dnqx also contains other interesting chemical elements:

Sodium (Na) 8 atoms
Chlorine (Cl) 2 atoms

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Structure of the Ligand-Binding and Transmembrane Domains of Kainate Receptor GLUK2 in Complex with the Positive Allosteric Modulator BPAM344 and Competitive Antagonist Dnqx (pdb code 8fwu). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 4 binding sites of Fluorine where determined in the Structure of the Ligand-Binding and Transmembrane Domains of Kainate Receptor GLUK2 in Complex with the Positive Allosteric Modulator BPAM344 and Competitive Antagonist Dnqx, PDB code: 8fwu:
Jump to Fluorine binding site number: 1; 2; 3; 4;

Fluorine binding site 1 out of 4 in 8fwu

Go back to Fluorine Binding Sites List in 8fwu
Fluorine binding site 1 out of 4 in the Structure of the Ligand-Binding and Transmembrane Domains of Kainate Receptor GLUK2 in Complex with the Positive Allosteric Modulator BPAM344 and Competitive Antagonist Dnqx


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Structure of the Ligand-Binding and Transmembrane Domains of Kainate Receptor GLUK2 in Complex with the Positive Allosteric Modulator BPAM344 and Competitive Antagonist Dnqx within 5.0Å range:
probe atom residue distance (Å) B Occ
B:F1001

b:21.0
occ:1.00
FAC B:2J91001 0.0 21.0 1.0
CAK B:2J91001 1.4 21.0 1.0
CAF B:2J91001 2.4 21.0 1.0
CAD B:2J91001 2.4 21.0 1.0
CG2 C:THR535 3.3 14.9 1.0
O C:LYS762 3.3 14.2 1.0
O C:MET534 3.4 20.0 1.0
CA C:GLY763 3.4 11.5 1.0
CB C:PRO532 3.5 34.1 1.0
CG C:PRO532 3.6 34.1 1.0
CAE B:2J91001 3.6 21.0 1.0
CAM B:2J91001 3.7 21.0 1.0
CA C:THR535 3.9 14.9 1.0
CB C:THR535 3.9 14.9 1.0
C C:LYS762 4.0 14.2 1.0
N C:GLY763 4.1 11.5 1.0
CAL B:2J91001 4.2 21.0 1.0
C C:MET534 4.2 20.0 1.0
CAD B:2J91005 4.2 27.6 1.0
N C:THR535 4.4 14.9 1.0
CAK B:2J91005 4.6 27.6 1.0
CAE B:2J91005 4.6 27.6 1.0
C C:GLY763 4.7 11.5 1.0
FAC B:2J91005 4.8 27.6 1.0
N C:TYR764 4.9 13.2 1.0
CD C:PRO532 5.0 34.1 1.0
CA C:PRO532 5.0 34.1 1.0

Fluorine binding site 2 out of 4 in 8fwu

Go back to Fluorine Binding Sites List in 8fwu
Fluorine binding site 2 out of 4 in the Structure of the Ligand-Binding and Transmembrane Domains of Kainate Receptor GLUK2 in Complex with the Positive Allosteric Modulator BPAM344 and Competitive Antagonist Dnqx


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Structure of the Ligand-Binding and Transmembrane Domains of Kainate Receptor GLUK2 in Complex with the Positive Allosteric Modulator BPAM344 and Competitive Antagonist Dnqx within 5.0Å range:
probe atom residue distance (Å) B Occ
B:F1005

b:27.6
occ:1.00
FAC B:2J91005 0.0 27.6 1.0
CAK B:2J91005 1.4 27.6 1.0
CAD B:2J91005 2.4 27.6 1.0
CAF B:2J91005 2.4 27.6 1.0
O B:LYS762 3.2 23.1 1.0
CA B:GLY763 3.3 18.8 1.0
O B:MET534 3.4 22.8 1.0
CB B:PRO532 3.4 20.0 1.0
OG1 B:THR535 3.4 20.4 1.0
CG B:PRO532 3.5 20.0 1.0
CAE B:2J91005 3.6 27.6 1.0
CAM B:2J91005 3.7 27.6 1.0
CA B:THR535 3.9 20.4 1.0
C B:LYS762 3.9 23.1 1.0
CG2 B:THR535 3.9 20.4 1.0
N B:GLY763 3.9 18.8 1.0
CB B:THR535 4.0 20.4 1.0
CAL B:2J91005 4.2 27.6 1.0
C B:MET534 4.3 22.8 1.0
CAD B:2J91001 4.3 21.0 1.0
C B:GLY763 4.4 18.8 1.0
N B:THR535 4.5 20.4 1.0
CAK B:2J91001 4.6 21.0 1.0
CAE B:2J91001 4.7 21.0 1.0
FAC B:2J91001 4.8 21.0 1.0
N B:TYR764 4.8 23.2 1.0
CD B:PRO532 4.8 20.0 1.0
CA B:PRO532 4.9 20.0 1.0

Fluorine binding site 3 out of 4 in 8fwu

Go back to Fluorine Binding Sites List in 8fwu
Fluorine binding site 3 out of 4 in the Structure of the Ligand-Binding and Transmembrane Domains of Kainate Receptor GLUK2 in Complex with the Positive Allosteric Modulator BPAM344 and Competitive Antagonist Dnqx


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Structure of the Ligand-Binding and Transmembrane Domains of Kainate Receptor GLUK2 in Complex with the Positive Allosteric Modulator BPAM344 and Competitive Antagonist Dnqx within 5.0Å range:
probe atom residue distance (Å) B Occ
D:F1001

b:23.6
occ:1.00
FAC D:2J91001 0.0 23.6 1.0
CAK D:2J91001 1.4 23.6 1.0
CAD D:2J91001 2.4 23.6 1.0
CAF D:2J91001 2.4 23.6 1.0
O D:LYS762 3.2 35.8 1.0
OG1 D:THR535 3.3 33.5 1.0
CA D:GLY763 3.4 30.7 1.0
O D:MET534 3.4 35.6 1.0
CB D:PRO532 3.5 29.6 1.0
CAE D:2J91001 3.6 23.6 1.0
CG D:PRO532 3.7 29.6 1.0
CAM D:2J91001 3.7 23.6 1.0
CG2 D:THR535 3.7 33.5 1.0
CA D:THR535 3.8 33.5 1.0
CB D:THR535 3.8 33.5 1.0
C D:LYS762 3.9 35.8 1.0
N D:GLY763 4.1 30.7 1.0
CAL D:2J91001 4.2 23.6 1.0
CAD D:2J91002 4.2 11.1 1.0
C D:MET534 4.3 35.6 1.0
N D:THR535 4.5 33.5 1.0
CAK D:2J91002 4.6 11.1 1.0
C D:GLY763 4.6 30.7 1.0
CAE D:2J91002 4.6 11.1 1.0
FAC D:2J91002 4.8 11.1 1.0
CD D:PRO532 5.0 29.6 1.0
N D:TYR764 5.0 35.0 1.0
C D:THR535 5.0 33.5 1.0

Fluorine binding site 4 out of 4 in 8fwu

Go back to Fluorine Binding Sites List in 8fwu
Fluorine binding site 4 out of 4 in the Structure of the Ligand-Binding and Transmembrane Domains of Kainate Receptor GLUK2 in Complex with the Positive Allosteric Modulator BPAM344 and Competitive Antagonist Dnqx


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Structure of the Ligand-Binding and Transmembrane Domains of Kainate Receptor GLUK2 in Complex with the Positive Allosteric Modulator BPAM344 and Competitive Antagonist Dnqx within 5.0Å range:
probe atom residue distance (Å) B Occ
D:F1002

b:11.1
occ:1.00
FAC D:2J91002 0.0 11.1 1.0
CAK D:2J91002 1.4 11.1 1.0
CAF D:2J91002 2.4 11.1 1.0
CAD D:2J91002 2.4 11.1 1.0
CG2 A:THR535 3.2 18.4 1.0
O A:LYS762 3.4 22.5 1.0
O A:MET534 3.5 14.1 1.0
CB A:PRO532 3.5 7.0 1.0
CA A:GLY763 3.6 15.4 1.0
CG A:PRO532 3.6 7.0 1.0
CAE D:2J91002 3.6 11.1 1.0
CAM D:2J91002 3.7 11.1 1.0
CB A:THR535 3.9 18.4 1.0
CA A:THR535 3.9 18.4 1.0
C A:LYS762 4.1 22.5 1.0
CAL D:2J91002 4.2 11.1 1.0
N A:GLY763 4.2 15.4 1.0
CAD D:2J91001 4.2 23.6 1.0
C A:MET534 4.3 14.1 1.0
N A:THR535 4.5 18.4 1.0
CAK D:2J91001 4.5 23.6 1.0
CAE D:2J91001 4.6 23.6 1.0
FAC D:2J91001 4.8 23.6 1.0
C A:GLY763 4.8 15.4 1.0
CD A:PRO532 5.0 7.0 1.0

Reference:

S.P.Gangwar, L.Y.Yen, M.V.Yelshanskaya, A.I.Sobolevsky. Positive and Negative Allosteric Modulation of GLUK2 Kainate Receptors By BPAM344 and Antiepileptic Perampanel. Cell Rep V. 42 12124 2023.
ISSN: ESSN 2211-1247
PubMed: 36857176
DOI: 10.1016/J.CELREP.2023.112124
Page generated: Tue Apr 25 20:18:21 2023

Last articles

Ca in 3P7R
Ca in 3P7G
Ca in 3P7Q
Ca in 3P7P
Ca in 3P7F
Ca in 3P7H
Ca in 3P5I
Ca in 3P75
Ca in 3P5H
Ca in 3P6B
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy