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Fluorine in PDB 8gcm: Cryo-Em Structure of the Prostaglandin E Receptor EP4 Coupled to G Protein

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Cryo-Em Structure of the Prostaglandin E Receptor EP4 Coupled to G Protein (pdb code 8gcm). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Cryo-Em Structure of the Prostaglandin E Receptor EP4 Coupled to G Protein, PDB code: 8gcm:
Jump to Fluorine binding site number: 1; 2;

Fluorine binding site 1 out of 2 in 8gcm

Go back to Fluorine Binding Sites List in 8gcm
Fluorine binding site 1 out of 2 in the Cryo-Em Structure of the Prostaglandin E Receptor EP4 Coupled to G Protein


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Cryo-Em Structure of the Prostaglandin E Receptor EP4 Coupled to G Protein within 5.0Å range:
probe atom residue distance (Å) B Occ
R:F501

b:30.0
occ:1.00
F08 R:YX9501 0.0 30.0 1.0
C07 R:YX9501 1.4 30.0 1.0
F09 R:YX9501 2.3 30.0 1.0
C05 R:YX9501 2.3 30.0 1.0
C10 R:YX9501 2.4 30.0 1.0
O11 R:YX9501 2.6 30.0 1.0
C06 R:YX9501 2.8 30.0 1.0
C12 R:YX9501 3.1 30.0 1.0
C04 R:YX9501 3.4 30.0 1.0
O R:VAL72 3.7 141.6 1.0
CA R:SER73 4.2 147.2 1.0
C01 R:YX9501 4.2 30.0 1.0
C R:VAL72 4.4 141.6 1.0
O R:SER73 4.5 147.2 1.0
C13 R:YX9501 4.5 30.0 1.0
C03 R:YX9501 4.5 30.0 1.0
N R:SER73 4.6 147.2 1.0
C R:SER73 4.8 147.2 1.0
C02 R:YX9501 4.9 30.0 1.0

Fluorine binding site 2 out of 2 in 8gcm

Go back to Fluorine Binding Sites List in 8gcm
Fluorine binding site 2 out of 2 in the Cryo-Em Structure of the Prostaglandin E Receptor EP4 Coupled to G Protein


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Cryo-Em Structure of the Prostaglandin E Receptor EP4 Coupled to G Protein within 5.0Å range:
probe atom residue distance (Å) B Occ
R:F501

b:30.0
occ:1.00
F09 R:YX9501 0.0 30.0 1.0
C07 R:YX9501 1.4 30.0 1.0
C05 R:YX9501 2.2 30.0 1.0
F08 R:YX9501 2.3 30.0 1.0
C10 R:YX9501 2.3 30.0 1.0
C12 R:YX9501 2.6 30.0 1.0
C06 R:YX9501 2.7 30.0 1.0
CB R:MET27 3.2 154.4 1.0
C04 R:YX9501 3.3 30.0 1.0
O11 R:YX9501 3.5 30.0 1.0
SD R:MET27 3.5 154.4 1.0
CG R:MET27 3.8 154.4 1.0
C01 R:YX9501 4.1 30.0 1.0
C13 R:YX9501 4.1 30.0 1.0
CA R:MET27 4.5 154.4 1.0
C03 R:YX9501 4.5 30.0 1.0
N R:PHE28 4.6 152.7 1.0
C R:MET27 4.6 154.4 1.0
C02 R:YX9501 4.8 30.0 1.0

Reference:

S.M.Huang, M.Y.Xiong, L.Liu, J.Mu, M.W.Wang, Y.L.Jia, K.Cai, L.Tie, C.Zhang, S.Cao, X.Wen, J.L.Wang, S.C.Guo, Y.Li, C.X.Qu, Q.T.He, B.Y.Cai, C.Xue, S.Gan, Y.Xie, X.Cong, Z.Yang, W.Kong, S.Li, Z.Li, P.Xiao, F.Yang, X.Yu, Y.F.Guan, X.Zhang, Z.Liu, B.X.Yang, Y.Du, J.P.Sun. Single Hormone or Synthetic Agonist Induces Gs/Gi Coupling Selectivity of Ep Receptors Via Distinct Binding Modes and Propagating Paths Proc.Natl.Acad.Sci.Usa V. 120 2023.
ISSN: ESSN 1091-6490
DOI: 10.1073/PNAS.2216329120
Page generated: Wed Jul 16 04:58:07 2025

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