Fluorine in PDB 8gcm: Cryo-Em Structure of the Prostaglandin E Receptor EP4 Coupled to G Protein

The binding sites of Fluorine atom in the Cryo-Em Structure of the Prostaglandin E Receptor EP4 Coupled to G Protein (pdb code 8gcm). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Cryo-Em Structure of the Prostaglandin E Receptor EP4 Coupled to G Protein, PDB code: 8gcm:
Jump to Fluorine binding site number: 1; 2;

Fluorine binding site 1 out of 2 in the Cryo-Em Structure of the Prostaglandin E Receptor EP4 Coupled to G Protein


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Cryo-Em Structure of the Prostaglandin E Receptor EP4 Coupled to G Protein within 5.0Å range: probe atom residue distance (Å) B Occ R:F501 b:30.0 occ:1.00 F08 R:YX9501 0.0 30.0 1.0 C07 R:YX9501 1.4 30.0 1.0 F09 R:YX9501 2.3 30.0 1.0 C05 R:YX9501 2.3 30.0 1.0 C10 R:YX9501 2.4 30.0 1.0 O11 R:YX9501 2.6 30.0 1.0 C06 R:YX9501 2.8 30.0 1.0 C12 R:YX9501 3.1 30.0 1.0 C04 R:YX9501 3.4 30.0 1.0 O R:VAL72 3.7 141.6 1.0 CA R:SER73 4.2 147.2 1.0 C01 R:YX9501 4.2 30.0 1.0 C R:VAL72 4.4 141.6 1.0 O R:SER73 4.5 147.2 1.0 C13 R:YX9501 4.5 30.0 1.0 C03 R:YX9501 4.5 30.0 1.0 N R:SER73 4.6 147.2 1.0 C R:SER73 4.8 147.2 1.0 C02 R:YX9501 4.9 30.0 1.0

Fluorine binding site 2 out of 2 in the Cryo-Em Structure of the Prostaglandin E Receptor EP4 Coupled to G Protein


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Cryo-Em Structure of the Prostaglandin E Receptor EP4 Coupled to G Protein within 5.0Å range: probe atom residue distance (Å) B Occ R:F501 b:30.0 occ:1.00 F09 R:YX9501 0.0 30.0 1.0 C07 R:YX9501 1.4 30.0 1.0 C05 R:YX9501 2.2 30.0 1.0 F08 R:YX9501 2.3 30.0 1.0 C10 R:YX9501 2.3 30.0 1.0 C12 R:YX9501 2.6 30.0 1.0 C06 R:YX9501 2.7 30.0 1.0 CB R:MET27 3.2 154.4 1.0 C04 R:YX9501 3.3 30.0 1.0 O11 R:YX9501 3.5 30.0 1.0 SD R:MET27 3.5 154.4 1.0 CG R:MET27 3.8 154.4 1.0 C01 R:YX9501 4.1 30.0 1.0 C13 R:YX9501 4.1 30.0 1.0 CA R:MET27 4.5 154.4 1.0 C03 R:YX9501 4.5 30.0 1.0 N R:PHE28 4.6 152.7 1.0 C R:MET27 4.6 154.4 1.0 C02 R:YX9501 4.8 30.0 1.0

S.M.Huang, M.Y.Xiong, L.Liu, J.Mu, M.W.Wang, Y.L.Jia, K.Cai, L.Tie, C.Zhang, S.Cao, X.Wen, J.L.Wang, S.C.Guo, Y.Li, C.X.Qu, Q.T.He, B.Y.Cai, C.Xue, S.Gan, Y.Xie, X.Cong, Z.Yang, W.Kong, S.Li, Z.Li, P.Xiao, F.Yang, X.Yu, Y.F.Guan, X.Zhang, Z.Liu, B.X.Yang, Y.Du, J.P.Sun. Single Hormone or Synthetic Agonist Induces Gs/Gi Coupling Selectivity of Ep Receptors Via Distinct Binding Modes and Propagating Paths Proc.Natl.Acad.Sci.Usa V. 120 2023.
ISSN: ESSN 1091-6490
DOI: 10.1073/PNAS.2216329120