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Atomistry » Fluorine » PDB 8gky-8hej » 8gkz » |
Fluorine in PDB 8gkz: Human Mitochondrial Serine Hydroxymethyltransferase (SHMT2) Y105F in Complex with Plp, Glycine and AGF362 InhibitorEnzymatic activity of Human Mitochondrial Serine Hydroxymethyltransferase (SHMT2) Y105F in Complex with Plp, Glycine and AGF362 Inhibitor
All present enzymatic activity of Human Mitochondrial Serine Hydroxymethyltransferase (SHMT2) Y105F in Complex with Plp, Glycine and AGF362 Inhibitor:
2.1.2.1; Protein crystallography data
The structure of Human Mitochondrial Serine Hydroxymethyltransferase (SHMT2) Y105F in Complex with Plp, Glycine and AGF362 Inhibitor, PDB code: 8gkz
was solved by
J.M.Katinas,
C.E.Dann Iii,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Human Mitochondrial Serine Hydroxymethyltransferase (SHMT2) Y105F in Complex with Plp, Glycine and AGF362 Inhibitor
(pdb code 8gkz). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Human Mitochondrial Serine Hydroxymethyltransferase (SHMT2) Y105F in Complex with Plp, Glycine and AGF362 Inhibitor, PDB code: 8gkz: Fluorine binding site 1 out of 1 in 8gkzGo back to![]() ![]()
Fluorine binding site 1 out
of 1 in the Human Mitochondrial Serine Hydroxymethyltransferase (SHMT2) Y105F in Complex with Plp, Glycine and AGF362 Inhibitor
![]() Mono view ![]() Stereo pair view
Reference:
J.M.Katinas,
M.J.Nayeen,
M.Schneider,
K.Shah,
A.N.Fifer,
L.M.Klapper,
A.Sharma,
K.Thalluri,
M.S.Van Nieuwenhze,
Z.Hou,
A.Gangjee,
L.H.Matherly,
C.E.Dann 3Rd.
Structural Characterization of 5-Substituted Pyrrolo[3,2- D ]Pyrimidine Antifolate Inhibitors in Complex with Human Serine Hydroxymethyl Transferase 2. Biochemistry 2024.
Page generated: Wed Jul 16 05:06:39 2025
ISSN: ISSN 0006-2960 PubMed: 38324671 DOI: 10.1021/ACS.BIOCHEM.3C00613 |
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