Fluorine in PDB 8gw8: The Human PTH1 Receptor Bound to An Intracellular Biased Agonist

The binding sites of Fluorine atom in the The Human PTH1 Receptor Bound to An Intracellular Biased Agonist (pdb code 8gw8). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the The Human PTH1 Receptor Bound to An Intracellular Biased Agonist, PDB code: 8gw8:
Jump to Fluorine binding site number: 1; 2; 3;

Fluorine binding site 1 out of 3 in the The Human PTH1 Receptor Bound to An Intracellular Biased Agonist


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of The Human PTH1 Receptor Bound to An Intracellular Biased Agonist within 5.0Å range: probe atom residue distance (Å) B Occ R:F601 b:73.4 occ:1.00 F1 R:KHF601 0.0 73.4 1.0 C22 R:KHF601 1.3 73.4 1.0 F3 R:KHF601 2.1 73.4 1.0 F2 R:KHF601 2.1 73.4 1.0 O4 R:KHF601 2.2 73.4 1.0 C21 R:KHF601 2.8 73.4 1.0 C23 R:KHF601 2.9 73.4 1.0 CD1 R:LEU416 3.4 75.0 1.0 C20 R:KHF601 4.1 73.4 1.0 C24 R:KHF601 4.1 73.4 1.0 CD2 R:LEU411 4.6 75.9 1.0 CG R:LEU416 4.8 75.0 1.0

Fluorine binding site 2 out of 3 in the The Human PTH1 Receptor Bound to An Intracellular Biased Agonist


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of The Human PTH1 Receptor Bound to An Intracellular Biased Agonist within 5.0Å range: probe atom residue distance (Å) B Occ R:F601 b:73.4 occ:1.00 F2 R:KHF601 0.0 73.4 1.0 C22 R:KHF601 1.3 73.4 1.0 F3 R:KHF601 2.1 73.4 1.0 F1 R:KHF601 2.1 73.4 1.0 O4 R:KHF601 2.2 73.4 1.0 C23 R:KHF601 2.8 73.4 1.0 C21 R:KHF601 2.9 73.4 1.0 CZ R:PHE454 3.1 87.5 1.0 CE2 R:PHE454 3.3 87.5 1.0 CE1 R:PHE454 4.1 87.5 1.0 C24 R:KHF601 4.1 73.4 1.0 C20 R:KHF601 4.2 73.4 1.0 CD2 R:PHE454 4.5 87.5 1.0 CD1 R:LEU416 4.6 75.0 1.0

Fluorine binding site 3 out of 3 in the The Human PTH1 Receptor Bound to An Intracellular Biased Agonist


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of The Human PTH1 Receptor Bound to An Intracellular Biased Agonist within 5.0Å range: probe atom residue distance (Å) B Occ R:F601 b:73.4 occ:1.00 F3 R:KHF601 0.0 73.4 1.0 C22 R:KHF601 1.3 73.4 1.0 F1 R:KHF601 2.1 73.4 1.0 F2 R:KHF601 2.1 73.4 1.0 O4 R:KHF601 2.2 73.4 1.0 C21 R:KHF601 3.5 73.4 1.0 C23 R:KHF601 4.1 73.4 1.0 CZ R:PHE454 4.1 87.5 1.0 C20 R:KHF601 4.6 73.4 1.0 CE2 R:PHE454 4.8 87.5 1.0 CD2 R:LEU411 4.8 75.9 1.0

M.Nishimura, K.Sawada, H.H.Okamoto, S.Hiratsuka, G.Nakamura, R.Kuwabara, H.Noda, M.Shimizu, T.Taguchi, A.Inoue, T.Murata, O.Nureki. Class B1 Gpcr Activation By An Intracellular Agonist Nature 2023.
ISSN: ESSN 1476-4687
DOI: 10.1038/S41586-023-06169-3