Fluorine in PDB 8jd0: Cryo-Em Structure of MGLU2-MGLU3 Heterodimer in Presence of NAM563

All present enzymatic activity of Cryo-Em Structure of MGLU2-MGLU3 Heterodimer in Presence of NAM563:
2.7.11.1; 5.2.1.8;

The binding sites of Fluorine atom in the Cryo-Em Structure of MGLU2-MGLU3 Heterodimer in Presence of NAM563 (pdb code 8jd0). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Cryo-Em Structure of MGLU2-MGLU3 Heterodimer in Presence of NAM563, PDB code: 8jd0:
Jump to Fluorine binding site number: 1; 2; 3;

Fluorine binding site 1 out of 3 in the Cryo-Em Structure of MGLU2-MGLU3 Heterodimer in Presence of NAM563


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Cryo-Em Structure of MGLU2-MGLU3 Heterodimer in Presence of NAM563 within 5.0Å range: probe atom residue distance (Å) B Occ 2:F1102 b:20.0 occ:1.00 F 2:J9R1102 0.0 20.0 1.0 C14 2:J9R1102 1.4 20.0 1.0 F1 2:J9R1102 2.2 20.0 1.0 F2 2:J9R1102 2.2 20.0 1.0 C13 2:J9R1102 2.4 20.0 1.0 N3 2:J9R1102 2.6 20.0 1.0 C11 2:J9R1102 2.8 20.0 1.0 C15 2:J9R1102 2.8 20.0 1.0 O1 2:J9R1102 2.8 20.0 1.0 CB 2:PHE780 3.2 48.3 1.0 C12 2:J9R1102 3.3 20.0 1.0 C10 2:J9R1102 3.8 20.0 1.0 C9 2:J9R1102 4.3 20.0 1.0 C16 2:J9R1102 4.4 20.0 1.0 CA 2:LEU777 4.6 48.3 1.0 CA 2:PHE780 4.8 51.9 1.0 O 2:PHE776 4.9 48.8 1.0

Fluorine binding site 2 out of 3 in the Cryo-Em Structure of MGLU2-MGLU3 Heterodimer in Presence of NAM563


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Cryo-Em Structure of MGLU2-MGLU3 Heterodimer in Presence of NAM563 within 5.0Å range: probe atom residue distance (Å) B Occ 2:F1102 b:20.0 occ:1.00 F1 2:J9R1102 0.0 20.0 1.0 C14 2:J9R1102 1.4 20.0 1.0 F 2:J9R1102 2.2 20.0 1.0 F2 2:J9R1102 2.2 20.0 1.0 C13 2:J9R1102 2.4 20.0 1.0 O1 2:J9R1102 2.7 20.0 1.0 C15 2:J9R1102 3.7 20.0 1.0 C12 2:J9R1102 3.9 20.0 1.0 N3 2:J9R1102 4.2 20.0 1.0 C11 2:J9R1102 4.2 20.0 1.0 CB 2:PHE780 4.3 48.3 1.0 CB 2:ASP725 4.9 49.5 1.0 CE2 2:TYR781 4.9 46.6 1.0 O 2:ASP725 5.0 50.0 1.0

Fluorine binding site 3 out of 3 in the Cryo-Em Structure of MGLU2-MGLU3 Heterodimer in Presence of NAM563


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Cryo-Em Structure of MGLU2-MGLU3 Heterodimer in Presence of NAM563 within 5.0Å range: probe atom residue distance (Å) B Occ 2:F1102 b:20.0 occ:1.00 F2 2:J9R1102 0.0 20.0 1.0 C14 2:J9R1102 1.4 20.0 1.0 F 2:J9R1102 2.2 20.0 1.0 F1 2:J9R1102 2.2 20.0 1.0 C13 2:J9R1102 2.4 20.0 1.0 C15 2:J9R1102 2.9 20.0 1.0 N3 2:J9R1102 3.5 20.0 1.0 O1 2:J9R1102 3.6 20.0 1.0 C11 2:J9R1102 4.3 20.0 1.0 C12 2:J9R1102 4.5 20.0 1.0 C10 2:J9R1102 4.6 20.0 1.0 C9 2:J9R1102 4.7 20.0 1.0 CB 2:LEU732 4.7 48.2 1.0 CA 2:LEU729 4.9 49.7 1.0 CB 2:LEU729 4.9 50.1 1.0 N 2:LEU729 4.9 48.3 1.0

X.Wang, M.Wang, T.Xu, Y.Feng, Q.Shao, S.Han, X.Chu, Y.Xu, S.Lin, Q.Zhao, B.Wu. Structural Insights Into Dimerization and Activation of the MGLU2-MGLU3 and MGLU2-MGLU4 Heterodimers. Cell Res. 2023.
ISSN: ISSN 1001-0602
PubMed: 37286794
DOI: 10.1038/S41422-023-00830-2